张敏 - 安徽大学 - 生命科学学院

个人简介

1993年毕业于安徽大学生物化学专业，获理学学士。2002年和2006年，分别获得中国科学技术大学生化与分子生物学专业的硕士和博士学位，2006年在美国佐治亚大学生化与分子生物学系作为访问学者工作和学习。2009年获得安徽省第五批优秀青年基金资助，2010年入选安徽省第七批学术与技术带头人后备人选。

研究领域

围绕生物大分子结构与功能的关系，开展重要蛋白质的克隆表达纯化、生化和酶学分析以及蛋白质晶体学等方面的研究工作

近期论文

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[1] Zhang M#, Zhang F#, Fang Y, Chen X, Chen Y, Zhang W, Dai H.E, Lin R, Liu L*, The non-canonical tetratricopeptide repeat (TPR) domain of fluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase, The Journal of Biological Chemistry, 2015, 290(28): 17559-17565 [2] Li J#, Wang X#, Gong W, Niu C*, Zhang M*, Crystallization and preliminary X-ray analysis of Rv1674c from Mycobacterium tuberculosis, Structural Biology and Crystallization Communications, 2015, 71(3): 354-357 [3] Ma C, Song M, Zhang Y, Yan M, Zhang M*, Bi H*, Nickle nanowires induce cell cycle arrest and apoptosis by generation of reactive oxygen species in Hela cells, Toxicology Reports, 2014, 1: 114-121 [4] Chen Y.Q, Chen C.C, He Y, Yu M, Xu L, Tian C.L, Guo Q.X, Shi J, Zhang M*, Li Y.M*, Efficient synthesis of trypsin inhibitor SFTI-1 via intramolecular ligation of peptide hydrazide, Tetrahedron Letters, 2014, 55(17): 2883-2886 [5] Liu G#, Shi Z #, Jiao S#, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L, Zhang Z, Zhou Z*, Zhang M*, Structure of MST2 SARAH domain provides insights into its interaction with RAPL, Journal of Structural Biology, 2014, 185(3): 366-374 [6] Zhang M, Xu H, Wang Y, Shi Z, Zhang N. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Acta Crystallographica Section F. 2013, 69(10), 1089-1093. [7] Zhang Z, Wang Y, Shi Z*, Zhang M*. Structure of zebrafish MO25. Acta Crystallographica Section F. 2013, 69(9), 989-993 [8] Chen Y, Wei J, Wang M, Shi Z, Gong W*, Zhang M*. The crystal structure of Arabidopsis VSP1 reveals the plant class C-like phosphatase structure of the DDDD superfamily of phosphohydrolases. PLoS One. 2012, 7(11):e49421 [9] Shi Z, Ge H, Zhao P, Zhang M*. Crystallization and preliminary crystallographic analysis of recombinant VSP1 from Arabidopsis thaliana. Acta Crystallographica Section F. 2010, 66(2), 201-203 [10] Zhang M, Wei Z, Chang S, Teng M, Gong W*. Crystal structure of a papainfold protein without the catalytic residue: a novel member in cysteine proteinase family. Journal of Molecular Biology. 2006, 358(1): 97-105 [11] Zhang M, Wu F, Wei Z, Xiao Y, Gong W*. Characterization and decolorization ability of a laccase from Panus rudis. Enzyme and Microbial Technology. 2006, 39(1): 92-97