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研究领域

1. 各种基因的转录增强子,抑制子和他们的调节因子是如何结合并共同调控癌基因的表达; 2. 肿瘤细胞是如何对胞外信号进行反应,胞外信号是如何传递的细胞内并调控基因的转录和翻译; 3. 肿瘤细胞中癌基因是如何具体转录和翻译的; 4. 肿瘤细胞的转移及侵润机制; 5. 肿瘤细胞的微环境是如何影响肿瘤的发展机理; 6. 肿瘤细胞的epithelia-mesenchymal transition机制。

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1. Li Y, Guo Z, Chen H, Dong Z, Pan ZK, Ding H, Su SB, Huang S. HOXC8-dependent cadherin 11 expression facilitates breast cancer cell migration through Trio and Rac. Genes & Cancer, 2011 Sep;2(9):880-8 2. Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S. Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis. Cancer Res. 3. Li Y, Kimura T, Tuyck RW, Laity JH, Andrews GK, Zinc-induced formation of a co-activator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP and Sp1. Mol. Cell. Biol.2008; 28: 4275-4284. 4. Li Y, Kimura T, Laity JH, Andrews GK, The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers. Mol Cell Biol. 2006 Aug; 26(15):5580-7. 5. Okumura F, Li Y, Itoh N, Nakanishi T, Isobe M, Andrews GK, Kimura T. The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter. Biochim Biophys Acta. 2011 Jan;1809(1):56-62 6. Chen H, Zhu G, Li Y, Padia RN, Dong Z, Pan ZK, Liu K, Huang S, Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. Cancer Res 7. Kimura T, Li Y, Okumura F, Itoh N, Nakanishi T, Sone T, Isobe M, Andrews GK, Chromium (VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem J. 2008 Nov 1; 415(3):477-82.

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