刘琳 - 安徽大学 - 生命科学学院

研究领域

实验室采用结构生物学、主要是生物大分子晶体学的方法，在原子尺度上研究细胞内重要分子机器的组装和调控机制。实验室近期开展了叶绿素合成途径中的酶及其调控蛋白的结构生物学研究。主要围绕谷氨酰-tRNA还原酶和镁螯合酶，探讨该途径中两个关键节点的催化与调控的分子基础。实验室也开展了对金属蛋白和蛋白-核酸相互作用的研究。

近期论文

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Dong W, Wang J, Niu G, ZhaoS, LiuL*. Crystal structure of thezinc-bound HhoA protease from Synechocystis sp. PCC 6803. FEBS Lett., 2016, 590(19):3435-3442. Zhao S, Wang X, Niu G, Dong W, Wang J, Fang Y, Lin Y, LiuL*. Structural basis for copper/silver binding by metallochaperone CopM. ActaCrystallogr. D Struct. Biol., 2016, 72(9): 997-1005. Wang X, Liu L*. Crystal structure and catalytic mechanismof 7-hydroxymethyl chlorophyll a reductase. J. Biol. Chem., 2016, 291(25): 13349-13359. Fang Y, Zhao S, Zhang F, Zhao A, Zhang W, Zhang M, Liu L*.The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex withFLU and GluTR-binding protein. Sci. Rep., 2016, 6: 19756. Chen X, Pu H, Fang Y, Wang X, Zhao S, Lin Y, Zhang M, DaiH, Gong W*, Liu L*. Crystal structure of the catalytic subunit of magnesiumchelatase. Nat. Plants, 2015, 1(9): 15125. Chen X, Pu H, Wang X, Long W, Lin R, Liu L*. Crystalstructures of GUN4 in complex with porphyrins. Mol. Plant., 2015, 8(7): 1125-1127. Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, Dai H,Lin R, Liu L*. The non-canonical tetratricopeptide-repeat (TPR) domain ofFluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase. J.Biol. Chem., 2015, 290(28): 17559-17565. Feng J, Zhao S, Chen X, Wang W, Dong W, Chen J, Shen JR,Liu L*, Kuang T*. Biochemical and structural study of Arabidopsis hexokinase 1.Acta Crystallogr. D Biol. Crystallogr., 2015, 71(2): 367-375. Chen X, Wang X, Feng J, Chen Y, Fang Y, Zhao S, Zhao A,Zhang M, Liu L*. Structural insights into the catalytic mechanism ofSynechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J. Biol.Chem., 2014, 289(37): 25690-25698. Zhao A, Fang Y, Chen X, Zhao S, Dong W, Lin Y, Gong W,Liu L*. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complexwith its stimulator protein. Proc. Natl. Acad. Sci. USA, 2014, 111(18): 6630-6635. Sun W, Gao F, Fan H, Shan X, Sun R, Liu L*, Gong W*. Thestructures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrAproteases. Acta Crystallogr. D Biol. Crystallogr., 2013, 69(5): 830-837. Sun R, Fan H, Gao F, Lin Y, Zhang L, Gong W*, Liu L*.Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligandlocking the hexameric resting state. J. Biol. Chem., 2012, 287(44):37564-37569. Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM,Davies DR*. Structural basis of toll-like receptor 3 signaling with double-strandedRNA. Science, 2008, 320(5874): 379-381. Wang M, Liu L, Wang Y, Wei Z, Zhang P, Li Y, Jiang X, XuH, Gong W*. Crystal structure of homoserine O-acetyltransferase from Leptospirainterrogans. Biochem. Biophys. Res. Commun., 2007, 363(4): 1050-1056. Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W*. Crystalstructure of human coactosin-like protein. J. Mol. Biol., 2004, 344(2): 317-323. Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W*. Expression,purification and preliminary crystallographic studies of human coactosin-likeprotein. Acta Cryst. D Biol. Crystallogr., 2004, 60(9): 1651-1653.