当前位置: X-MOL首页全球导师 国内导师 › 廖新化

个人简介

教育背景: 2000/9 - 2005/7,中科院生物化学与细胞生物学研究所,生物化学与分子生物 学博士 1996/9 - 2000/5,兰州大学,生物学学士 工作经历: 2017/10 – 至今, 上海大学,生命科学学院,教授 2014/2 – 2017/10,福建医科大学,转化医学研究院/基础医学院,闽江学者特聘教授 2010/12 - 2013/12,美国贝勒医学院,干细胞与再生医学研究中心,博士后 2005/12 - 2010/12,美国国立卫生研究院,糖尿病、消化道疾病及肾病研究所,细胞与发育生物学部,访问学者/博士后

研究领域

皮肤和毛囊干细胞维持、激活和再生的原理 皮肤和毛发相关疾病治疗关键技术的研究 肿瘤干细胞调控的原理和相关药物的开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

"1. Zheng, M.*, Xu, H.*, Liao, X.H.*, Chen, C.P., Zhang, A.L., Lu, W.X., Wang, L., Yang, D.Y., Wang, J., Liu, H.K., Zhou, X.Z. and Lu, K.P.# . (2017) Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma, Oncotarget, 8(18):29771-29784 (*共同一作). 2. Liao, X.H*., Zhang, A.L.*, Zheng, M. *, Li, M.Q., Chen, C.P., Xu, H.J., Chu, Q.S., Yang, D.Y., Lu, W.X., Tsai, T.F., Liu, H.K., Zhou, X.Z., Lu, K.P. (2017) Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways, Scientific Reports, 6;7:43639 3. Liao, X.H., and Kimmel, A.R. (2017). A Unique High-Throughput Assay to Identify Novel Small Molecule Inhibitors of Chemotaxis and Migration, Current Protocol in Cell Biology, 74:12.11.1-12.11.13. (杂志专评在Advanced Science News推介 ) 4. Jiang, L.C., Wang, L., Chen, C.P., M.Q., L., and Liao, X.H.# (2017). Lgr6 is dispensable for epidermal cell proliferation and wound repair. Experimental Dermatology, 26(2):105-107. (通讯作者) 5. Wang J.C.*, Liao, X.H.*, Zheng M., Yang D.Y., Liu H.K. Zhou X.Z. and Lu K.P. (2016) The roles of prolyl isomerase Pin1 in cancer-related viral and bacterial infections, Current Molecular Medicine, 16(9):793-802 (co-first author) 6. Liao, X.H. #, Meena, N.P., Southall, N., Liu, L., Swaroop, M., Zhang, A.L., Xiang, J.J., Parent, C.A., Zheng, W., and Kimmel, A. R. (2016) A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration. Scientific Reports, 9;6:22273. (共同通讯作者) 7. Liao, X.H., and Nguyen, H. (2014). Epidermal expression of Lgr6 is dependent on nerve endings and Schwann cells. Experimental Dermatology. 23(3):195-8. 8. Liao, X.H., Buggey, J., Lee, Y.K., and Kimmel, A.R. (2013). Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Molecular Biology of the Cell, 24, 2146-2155. 9. Liao, X.H., Buggey, J., and Kimmel, A.R. (2010). Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. Journal of Cell Science 123, 983-992. (被 Faculty 1000推介) 10. Liao, X.H., and Kimmel, A.R. (2009). Biochemical responses to chemoattractants in Dictyostelium: ligand-receptor interactions and downstream kinase activation. Methods in Molecular Biology 571, 271-281. 11. Liao, X.H., Majithia, A., Huang, X., and Kimmel, A.R. (2008). Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism. Amino Acids 35, 761-770. 12. Liao, X.H., Zhang, M.L., Yang, C.P., Xu, L.X., and Zhou, J.Q. (2005). Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. The Biochemical Journal 390, 169-176. 13. 向建,陈鹏,张莉,卢坤平#,廖新化# (2016) Pin1在皮肤组织中的表达以及可诱导转基因小鼠模型的建立。中国实验动物学报, 24(4):333-338 14. 廖新化#(2013)从骨科医生到诺贝尔奖得主-Shinya Yamanaka ( 山中伸弥) 发现iPS 的研究历程。生命的化学, 33 (1), 118-123 15. 廖新化# (2009) 端粒和端粒酶的发现历程。 生命的化学, 29 (6), 775-780d 16. Yang, D., Luo, W., Wang, J., Zheng, M., Liao, X.H., Zhang, N., Lu, W., Wang, L., Chen, A.Z., Wu, W.G., et al. (2018). A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways. Journal of controlled release 269, 405-422. 17. Yan, X., Zhu, Z., Xu, S., Yang, L.N., Liao, X.H., Zheng, M., Yang, D., Wang, J., Chen, D., Wang, L., et al. (2017). MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Scientific reports 7, 45915. 18. Xu, Y., Xu, Y., Liao, L., Zhou, N., Theissen, S.M., Liao, X.H., Nguyen, H., Ludwig, T., Qin, L., Martinez, J.D., et al. (2013). Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. The American Journal of Pathology 183, 1281-1292. 19. Brzostowski, J.A., Sawai, S., Rozov, O., Liao, X.H., Imoto, D., Parent, C.A., and Kimmel, A.R. (2013). Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay. Journal of Cell Science 126, 4614-4626. 20. Faix, J., Linkner, J., Nordholz, B., Platt, J.L., Liao, X.H., and Kimmel, A.R. (2013). The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci. Methods in Molecular Biology 983, 249-267."

推荐链接
down
wechat
bug