个人简介
1993年本科毕业于西北农业大学畜牧专业;1996年硕士毕业于贵州农学院动物科学学院动物遗传育种专业;1999年7月博士毕业于西北农林科技大学动物遗传育种与繁殖专业。2002-2003年间在美国Georgia State University 从事细胞与分子生理学博士后研究工作。主持或以主要学术骨干参加科技部“973”、教育部留学归国人员基金、上海市自然科学基金、上海市教委重点创新项目、上海市农委攻关项目多项。讲授“动物学”、“生命科学导论”、“现代生物技术导论”等课程。荣获2005年度“上海大学优秀青年教师”称号,2008年度“上海市优秀青年教师”称号。
研究领域
主要从事恶性脑胶质瘤发生发展过程中信号通路的分子机制以及天然产物对胶质瘤作用的分子机制等方面的研究工作。
近期论文
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"1. Xu Y†, Li X†, Zhang S, Shen D, Li H, Wu Y, Qiu Y, Ji Y, Chen F*. Targeting Stat3 Suppresses Growth of U251 Cell-Derived Tumour in Nude Mice. Journal of Clinical Neuroscience. 2012;19:443-446.
2. Zhao J†, Xu Y†, Zong Y, Zhang S, Song Y, Yu K, Li Z, Ji Y, Qiu Y, Chen F*. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology. 2011;16:232-235.
3. Chen F*, Zheng D, Xu Y, Luo Y, Li H, Yu K, Song Y, Zhong W, Ji Y. Down-Regulation of Kir6.2 Affects Calcium Influx and Insulin Secretion in HIT-T15 Cells. Journal of Pediatric Endocrinology & Metabolism. 2010;23:709-717.
4. Chen F*, Xu Y, Luo Y, Zheng D, Song Y, Yu K, Li H, Zhang L, Zhong W, Ji Y. Down-Regulation of Stat3 Decreases Invasion Activity and Induces Apoptosis of Human Glioma Cells. Journal of Molecular Neuroscience. 2010;40:353-359.
5. Chen F*, Ren W, Yang Y, Shen D, Zong Y, Xu S, Duan Y, Qian Y, Ji Y. Reciprocal effects of cultured glioma cells on neural stem cells by their conditioned medium. Journal of Clinical Neuroscience. 2009;16:1619-1623.
6. Chen F*,Qian Y, Duan Y, Ren W, Yang Y, Zhang C, Qiu Y, Ji Y. Down-regulation of 67LR reduces the migratory activity of Human Glioma Cell. Brain Research Bulletin. 2009;79:402-408.
7. Yang Y, Qiu Y, Ren W, Gong J, Chen F*. An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas. Molecular Carcinogenesis. 2008;47:893-903.
8. Ren W, Duan Y, Yang Y, Ji Y, Chen F*.Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. Neurological Research. 2008;30:297-301.
9. Yang Y, Ren W, Chen F*. Knockdown of Stat3 in C17.2 neural stem cells facilitates the generation of neurons: a possibility of transplantation with a low level of oncogene. NeuroReport. 2006;17:235-238.
10. Ren W, Guo Q, Yang Y, Chen F*. bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons. Neurological Research. 2006;28:87-90.
11. Chen F*, Guo Q, Yang Y, Song H, Wen T. Inhibition of AF116909 gene expression enhances the differentiation of neural stem cells. Neurological Research. 2005;27:557-561.
12. Wu J,Piao H,Chen F et al.Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP[J]. Cell Physiol. 2004 Jan;198(1):73-81.
13. Wang X,Wu J,Chen F et al.Hypercapnic acidosis activates KATP channels in vascular smooth muscles[J]. Circ Res. 2003 Jun 13;92(11):1225-1232.
14. Mao J,Wu J,Chen F et al. Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis[J].Biol Chem. 2003 Feb 28;278(9):7091-7098."