张立新 - 华东理工大学 - 生物工程学院

个人简介

张立新，理学博士，教授。现任华东理工大学生物反应器工程国家重点实验室主任，国家杰出青年（终评优秀），973项目首席科学家。2014年获得“英国皇家学会-罗氏青年科学家”奖；2016获得“国家科技进步二等奖”；2017年获得“药明康德生命化学研究奖”。主编或参与编写八部学术专著（英文四部），获得16项国际专利发明授权，26项国内发明授权专利，目前已在Nature等杂志发表200多篇论文。教育经历 1990/09-1994/06：中国科学院应用生态研究所微生物制药学专业硕博连读 1986/09-1990/06：山东大学微生物学专业学士工作经历 2018.3-至今华东理工大学生物反应器工程国家重点实验室主任 2016.6-至今华东理工大学生物工程学院教授/博导 2006.02-2016.6：中国科学院微生物研究所研究员/博导/中国科学院病原微生物与免疫学重点实验室副主任，国家杰出青年基金获得者并终评优秀, “973计划”首席科学家 2004.10-2006.02：中国科学院广州生物医药与健康研究院研究员/博导/海洋微生物天然产物药物研究室主任 2004.01-2006.02：美国SynerZ制药公司董事长 2001.10-2003.12：美国CETEK制药公司微生物学部主任 1998.12-2001.10：美国Microbia生物制药公司高级科学家 1998.07-1998.12：美国爱默瑞大学助理教授 1994.12-1998.06：美国爱默瑞大学微生物药理学博士后研究

研究领域

(1) 张立新教授在微生物化学生物学领域做出了系统性和开创性的研究：利用自主构建的我国南海微生物天然产物资源库，进行高通量筛选活性化合物，解决了传统的单个钓鱼式的药物筛选模式无法满足国家和社会对创新药物的巨大需求的问题，发现了其作用机制并提高产量, 揭示了库中青蒿素类的新环内过氧桥键合酶的功能和机制。特别是具有自主知识产权的抗真菌药物新机制。

近期论文

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1.Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang Lixin*, Pinghua Liu*, and Yan Jessie Zhang*. 2015. Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme. Nature, 527, 539–543. (IF＝41.296) 2.Wang Minxuan, Carver Jeremy J, Shi Wenyuan, Liu Xueting, Zhang Lixin, Knight Rob, Moore Bradley S, Dorrestein Pieter C*, Bandeira Nuno*, et al. 2016. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology. 34(8):828-837. doi: 10.1038/nbt.3597. (IF=43.113) 3.Wang Qian, Song Fuhang, Xiao Xue, Huang Pei, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Wang Jian, Guo Hui, He Wenni, Xie Feng, Dai Huanqin, Liu Miaomiao, Chen Caixia, Xu Hao, Liu Mei, Andrew M. Piggott, Liu Xueting*, Robert J. Capon*, Zhang Lixin*. Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as antitubercular prodrugs. Angew. Chem.-Int. Edit. 2013,52, 1231-1234. (IF＝13.560) 4.Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C*, Zhang L*. 2015. Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A. 112 (39), 12181-6. (IF＝10.6) 5.Ashforth Elizabeth Jane, Fu Chengzhang, Liu Xiangyang, Dai Huanqin, Song Fuhang, Guo Hui, Zhang Lixin*. Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep.2010,27, 1709-1719. (IF＝9.8) 6.Zhuo Ying, Zhang Wenquan, Chen Difei, Gao Hong, Tao Jun, LiuMei, Gou Zhongxuan, Zhou Xianlong, Ye Bangce, Zhang Qing, Zhang Siliang, Zhang Lixin*. Reversebiological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis, Proc. Natl. Acad. Sci. U S A, 2010,107(25), 11250-11254. (IF＝10) 7.Zhang Lixin*, Yan Kezhi, Zhang Yu et al. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci U S A, 2007, 104(11), 4606-4611.(IF=10.563) 8.Gao Q, Tan GY, Xia X, Zhang L*. Learn from microbial intelligence for avermectins overproduction. Curr Opin Biotechnol, 2017, 48:251-257.(IF=9.6) 9.Zhang Lixin, J. Chen and H. Fu. 1999. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.Proc Natl Acad Sci U S A, 96 (15): 8511-8515.(IF=10.563) 10.Joseph Scott Zarins-Tutt, Tania Triscari Barberi, Hong Gao, Andrew Mearns-Spragg, Lixin Zhang, David J. Newman, Rebecca Jane Miriam Goss*. Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products. Nat Prod Rep. 2016, 33(1):54-72. (IF=10.107) 11.Jing Zhao , Yuhong Du, John R. Horton, Anup K. Upadhyay, Bin Lou, Yan Bai, Xing Zhang, Lupei Du, Minyong Li, Binghe Wang, Lixin Zhang, Joseph T. Barbieri, Fadlo R. Khuri, Xiaodong Cheng, Haian Fu. 2011. Discovery and structural characterization of FOBISIN 101 as a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl. Acad. Sci. USA. 108(39): 16212-6. (IF=10.563) 12. Kyrpides Nikos C*, Hugenholtz P, Eisen JA, Woyke T, Göker M, Parker CT, Amann R, Beck BJ Zhang Lixin, Klenk Hans-Peter*, et al. Genomic encyclopedia of bacteria and archaea: sequencing a myriad of type strains. PLoS biology, 2014, 12(8):e1001920. (IF=12.807)