个人简介
工学博士，华东理工大学生物工程学院教授，博士生导师， 国家生化工程技术研究中心（上海）副主任。1963年8月出生于上海，1985获华东化工学院学士学位, 88年获硕士学位。96年于华东理工大学获生物化工工学博士学位。88年毕业后留校从事国家七.五攻关项目，溶氧电极和谷氨酸电极的研制以及葡萄糖氧化酶发酵、提纯工作等。90年10月在大阪大学发酵工学科从事基因工程研究一年；91年应邀到英国Bath大学进行膜发酵研究一年。92年12月回国后,获国家教委资助的留学回国人员基金, 从事螺旋霉素膜过滤发酵研究, 国家自然科学基金项目葡萄糖氧化酶膜透析发酵以及葡萄糖氧化酶菌种选育工作, "利用高技术改进庆大霉素菌种及发酵工艺", "果糖基转移酶"的研究,担任研究生学位课程"发酵调控学"本科生"发酵生理学""生物工程专业英语"等教学工作。97年开始从事九五攻关项目"红霉素发酵新技术研究"及国家86.3子课题，酿酒酵母基因工程菌高密度培养。98年从事毕赤酵母基因工程菌高密度生产表达人血清白蛋白中试研究。99年主持国家自然科学基金项目"小单孢菌分泌机制研究"， 98年任硕士生导师。现为发酵工程硕士点学术带头人之一。1999年晋升为教授，2001年3月晋升为生物化工专业博士生导师, 目前已有20余人获博士学位，其中一人获上海市优秀博士论文。2004年为微生物学硕士点负责人。完成国家“十五”攻关梅岭霉素工艺优化，国家十五“863”及国家十五“863”重大科技专项课题基因工程微生物表达系统发酵过程优化平台技术研究。并与企业合作进行肌苷、鸟苷发酵，阿氟菌素及头孢菌素C及毕赤酵母疟疾疫苗、植酸酶高表达等课题研究。2000年获教育部高等学校骨干教师资助计划，并于2002年获得高等学校优秀骨干教师称号。2001年获上海市曙光计划资助，2006年获曙光跟踪项目资助。2004年分别获得日本明治乳业生命科学奖和韩国SK基金资助。2006年作为项目负责人完成国家十一五“863”重点项目“头孢菌素C发酵工业用菌种改造和代谢工程技术研究（680万元）”及十一五“973”子课题等项目，并且所在研究团队于2011年2月荣获科技部授予的“十一五”国家科技计划执行优秀团队奖。近期正在承担十二五国家重大新药创制项目及教育部高校博士点基金及十二五“973”子课题等项目。作为项目负责人先后和英国GMX公司、韩国CJ公司、荷兰DSM公司及英国Strathclyde大学成功进行国际合作研究。2007年6月至12月在美国佐治亚大学遗传系高级访问学者。表学术论文200余篇。其中SCI收录论文136篇，EI收入100篇。学术专著及教材4部。迄今已申报包括国际PCT在内的发明专利1 项，申报国家发明专利45项，其中17项已经获得授权。2002、2004、2011年3次获得国家科技进步二等奖（分别为第2，第3，第2完成人）。
近期论文
查看导师新发文章
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1. Guo Qian, Chu Ju*, Zhuang Yingping, Gao Yang. Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement [J]. Bioprocess and Biosystems Engineering, 2016, 39(2): 255-265.
2. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Enhanced l-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis [J]. Applied Microbiology and Biotechnology, 2016, 100(5): 2301-2310.
3. Lu Fei, Wang Zejian, Zhao Wei, Chu Ju*, Zhuang Yingping. A simple novel approach for real-time monitoring of sodium gluconate production by on-line physiological parameters in batch fermentation by Aspergillus niger [J]. Bioresource Technology, 2016, 202: 133-141.
4. Tian Xiwei, Zhang Ning, Yang Yi, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. The effect of redox environment on l-lactic acid production by Lactobacillus paracasei—A proof by genetically encoded in vivo NADH biosensor [J]. Process Biochemistry, 2015, 50(12): 2029-2034.
5. Lu Hongzhong, Liu Xiaoyun, Huang Mingzhi*, Xia Jianye, Chu Ju*, Zhuang Yingping, Zhang Siliang, Noorman Henk. Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger [J]. Microbial Cell Factories, 2015, 14(1): 147-160.
6. Lu Fei, Ping Kangkang, Wen Lin, Zhao Wei, Wang Zejian*, Chu Ju*, Zhuang Yingping. Enhancing gluconic acid production by controlling the morphology of Aspergillus niger in submerged fermentation [J]. Process Biochemistry, 2015, 50(9): 1342-1348.
7. Tang Wenjun, Pan Ao, Lu Hongzhong, Xia Jianye*, Zhuang Yingping, Zhang Siliang, Chu Ju*, Noorman Henk. Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer [J]. Biochemical Engineering Journal, 2015, 99: 167-176.
8. Lu Hongzhong, Li Chao, Tang Wenjun, Wang Zejian, Xia Jianye*, Zhang Siliang, Zhuang Yingping, Chu Ju*, Noorman Henk. Dependence of fungal characteristics on seed morphology and shear stress in bioreactors [J]. Bioprocess and Biosystems Engineering, 2015, 38(5): 917-928.
9. Shi Fei, Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger [J]. Journal of Microbiological Methods, 2015, 109: 134-139.
10. Chen Yong, Wang Zejian, Chu Ju*, Xi Beili, Zhuang Yingping. The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m3 fermenter [J]. Bioprocess and Biosystems Engineering, 2015, 38(1): 105-112.
11. Wang Guan, Tang Wenjun, Xia Jianye, Chu Ju*, Noorman Henk, van Gulik Walter M.. Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses [J]. Engineering in Life Sciences, 2015, 15(1): 20-29.
12. Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. High-throughput system for screening of Monascus purpureus high-yield strain in pigment production [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-7.
13. Zhang Qiang, Chen Yong, Hong Ming, Gao Yang, Chu Ju*, Zhuang Yingping, Zhang Siliang. The dynamic regulation of nitrogen and phosphorus in the early phase of fermentation improves the erythromycin production by recombinant Saccharopolyspora erythraea strain [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-6.
14. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on l-lactic acid production efficiency by Lactobacillus paracasei [J]. Process Biochemistry, 2014, 49(12): 2049-2054.
15. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. l-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination [J]. Bioprocess and Biosystems Engineering, 2014, 37(9): 1917-1923.
16. Wang Guan, Chu Ju*, Noorman Henk, Xia Jianye, Tang Wenjun, Zhuang Yingping, Zhang Siliang. Prelude to rational scale-up of penicillin production: a scale-down study [J]. Applied Microbiology and Biotechnology, 2014, 98(6): 2359-2369.
17. Zhu Pei, Chen Daijie, Liu Wenbin, Zhang Jianbin, Shao Lei, Li Ji-an, Chu Ju*. Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion [J]. Bioresource Technology, 2014, 153: 95-100.
18. Chen Yong, Huang Mingzhi, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang. Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis [J]. Bioprocess and Biosystems Engineering, 2013, 36(10): 1445-1453.
19. Tan Jun, Chu Ju*, Hao Yuyou, Wang Yonghong, Yao Sichao, Zhuang Yingping, Zhang Siliang. A high-throughput screening strategy for accurate quantification of erythromycin [J]. Journal of the Taiwan Institute of Chemical Engineers, 2013, 44(4): 538-544.
20. Chen Yong, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang, Yu Xiaoguang. Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate [J]. Bioresource Technology, 2013, 134: 173-179.
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