郁惠蕾 - 生物反应器工程国家重点实验室 -

个人简介

2008年毕业于华东理工大学生物化工专业，获工学博士学位并获2010年优秀百篇博士论文提名奖。2010年起任华东理工大学生物反应器工程国家重点实验室副研究员，生物催化团队的主要成员之一。2012年赴日本短期学习嗜热微生物的培养，2013年受国家留学基金委资助赴美国麻省理工学院进修一年。主持国家自然科学基金，973子课题和霍英东基金等项目，发表SCI论文40余篇，申请发明专利9项，其中授权中国发明专利3项，公开4项，实现成果转让2项

研究领域

氧化还原酶的定向挖掘和改造多酶组合催化体系构建和调控生物催化制备重要手性中间体

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Huang L, Ma HM, Yu HL* and Xu JH*. Altering the substrate specificity of a reductase CgKR1 from Candida glabrata by protein engineering for bioreduction of aromatic α-keto esters. Adv.Synth.Catal. DOI 10.1002/adsc.201300775 Xu YP, Guan Y H, Yu HL*, Ni Y, Ma BD, Xu JH*. Improved o-chlorobenzoylformate bioreduction by stabilizing aldo-keto reductase YtbE with additives. J Mol Catal B: Enzymatic http://dx.doi.org/10.1016/j.molcatb.2014.03.006 Ma BD, Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, and Xu JH *. Increased Catalyst Productivity in α-Hydroxy Acids Resolution by Esterase Mutation and Substrate Modification. ACS Catal. 2014, 4 (3): 1026–1031 Zhang WX, Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space–time yield of 916 g L–1 d–1 using a new bacterial reductase ArQR. Org. Lett. 2013, 15(19): 4917–4919 Xu GC, Yu HL*, Zhang ZJ, Xu JH*. Stereocomplementary bioreduction of β-ketonitrile without ethylated byproduct. Org. Lett. 2013, 15(21): 5408–5411 Ma BD, Yu HL*, Pan J, Liu JY, Ju X, Xu JH*.A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: Catalytic properties and performance in kinetic resolution of alpha-hydroxy acids. Bioresour. Technol. 2013, 133: 354-360 Xu GC, Yu HL*, Zhang XY and Xu JH*. Access to optically active aryl halohydrins using a substrate-tolerant carbonyl reductase discovered from Kluyveromyces thermotolerans. ACS Catal. 2012, 2(12): 2566–2571 Zou ZZ, Yu HL*, Li CX, Zhou XW, Hayashi C, Sun J, Liu BH, Imanaka T, Xu JH*. A new thermostable beta-glucosidase mined from Dictyoglomus thermophilum: Properties and performance in octyl glucoside synthesis at high temperatures. Bioresour. Technol. 2012, 118: 425-430 Yu HL, Ou L, Xu JH*. New trends in non-aqueous biocatalysis. Curr. Org. Chem. 2010, 14(14): 1424-1432 Yu HL, Xu JH*, Lu WY, Lin GQ. Discovery and utilization of biocatalysts for chiral synthesis: An overview of Chinese scientists research and development. Adv. Biochem. Eng. Biotechnol. 2009, 113: 1-31 Yu HL, Xu JH*, Lu WY, Lin GQ. Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst. J. Biotechnol. 2008, 133: 469-477 Yu HL, Xu JH*, Wang YX, Lu WY, Lin GQ. Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media. J. Comb. Chem. 2008, 10: 79-87 郁惠蕾, 许建和译校 (许建和、陶军华、林国强主译). 面向制药工业的生物催化—发现、开发及生产. 化学工业出版社. 2010