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个人简介

学习与工作经历 2010/06-2011/06,美国德克萨斯州农工大学,化学系,访问学者 2000/07-至今,华东理工大学,生物工程学院,副教授 2003年3月--2006年6月 华东理工大学,工学博士 1997年9月--2000年6月 华东师范大学,理学硕士

研究领域

一、蛋白质或多肽类药物的开发及应用研究 1. 采用基因工程技术,对多肽分子基因进行克隆、基因突变,转入大肠杆菌、酵母或动物细胞等表达体系进行大规模表达。为研究重组蛋白分子的作用机理,性质改良等进行体内、外的研究工作,为新药的开发提供实验基础。 2. 蛋白质或多肽的非天然氨基酸定点修饰,采用密码子的扩展技术获得非天然氨基酸的编码单元,利用基因工程的手段获得指定位点非天然氨基酸修饰的蛋白质或多肽,为新型蛋白质或药物的开发开拓应用技术,也为生物体内翻译后修饰蛋白质的生物功能的研究提供便利工具。 二、对传统中药材的开发研究 从白癜风治疗复方中分离活性成份,进行其结构、生物学功能、白斑复黑机制的研究。研究比较各不同活性成份中物资的互作及补变化,用于新药的研究及开发。 三、根据不同生物体对外界影响因素的不同表现,在基因水平上对其进行序列差异的研究,从而判断出和生物体某些性状相关的基因,为人类疾病易感基因的诊断、微生物体高效生产生物化学产品提供理论基础.

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Xiujuan Xin*, Jing Zhang, Yaning Chang, Yixin Wu. Association Study of TAC3 and TACR3 Gene Polymorphisms with Precocious Puberty of Chinese Girl. Journal of Pediatric Endocrinology and Metabolism. 28(1-2):65-71, 2015 2. Xiujuan Xin; Wenshe Liu; Liyun Sun*. Improving the Bioactivity of rHirudin with Boronophenylalanine Site-Specific Modification. Molecular Medicine Reports. 11(5):3774-9, 2015 3. Liyun sun; yuxia zhao; shaohua gu; yumin mao; chaoneng ji; xiujuan xin*. Regulation of HMOX1 genes by the transcription factor AP-2δ with unique DNA binding site. Molecular Medicine Reports. 10(1), 423-8, 2014 4. Xiujuan Xin, Junhua Xiao﹡, Xiaohui Luan, Yuxun Zhou, Daru Lu, Dongzhi Wei﹡, Shengli Yang. Association Study of Six Activity SNPs in adrenal steroid hormone Metabolism and IBM related genes with Precocious Puberty in Chinese Girls, Neuroendocrinology Letters, 27, 219-224, 2006 5. Junhua Xiao, Xiujuan Xin, Xiaohui Luan, Dongzhi Wei﹡, Shengli Yang. A Modified Simple PCR-RFLP Method for Single Nucleotide Polymorphisms (SNPs) Typing, Genetic molecular biology, 29, 562-565, 2006 6. Xiujuan Xin, Jianwen Liu, Xing Li,Jianjiang Zhong, Dongzhi Wei. Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation. American Journal of therapeutics, 13(3):205-210, 2006 7. Xiujuan Xin, Xiaohui Luan, Junhua Xiao*, Dongzhi Wei, Jianhui Wang, Daru Lu and Shengli Yang. Association study of four activity SNPs of CYP3A4 with the precocious puberty in Chinese girls, Neuroscience Letters, 381, 284-288, 2005 8. Xiujuan Xin, Jianjiang Zhong, Dongzhi Wei﹡ and Jianwen Liu﹡. Protection effect of 20(S)-ginsenoside Rg2 extracted from cultured Panax notoginseng cells on hydrogen Peroxide-induced cytotoxity of human umbilical cord vein endothelial cells in vitro, Process Biochemistry, 40, 3202-3205, 2005. 9. Xiujuan Xin, Dongzhi Wei﹡, Changsong Dong, Wenyu Zhou, Jianwen Liu. Effect of modification of L-asparaginase by chitosan on enzyme activity and antigenity, Journal of East China University of Science and Technology, 28,380-382, 2002 10.Xiujuan Xin; Jie Bao﹡. Effect of pyk gene location on constructing dATP conversion E. coli strain. Advances in Bioscience and Biotechnology, 4, 75-80, 2013 11. Jianming Liu; Xiujuan Xin; Chunxiu Li; Jianhe Xu; Jie Bao﹡. Cloning of Thermostable Cellulase Genes of Clostridium thermocellum and Their Secretive Expression in Bacillus subtilis. Apply Biochemistry and Biotechnology, 166, 652-662, 2012 12. Shuhong Gao, Jie Bao﹡, XiaoMing Gu, XiuJuan Xin, ChangHua Chen, Dewey D.Y. Ryu. Substrate promiscuity of pyruvate kinase on various deoxynucleoside diphosphates for synthesis of deoxynucleoside triphosphates, Enzyme and Microbial Technology, 43,455-459, 2008

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