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个人简介

本科毕业于清华大学化学系,华东理工大学与京都大学联合培养博士。1995年起历任华东理工大学助研、副研、教授。现任教育部生物反应器工程国家重点实验室主任,兼上海生物制造协同创新中心主任。亚洲生物技术联合会执委,第一届亚洲生物技术大会共同主席,Bioresources and Bioprocessing主编及Biotechnology and Bioprocess Engineering副主编。

研究领域

新酶元件设计表征与结构改造; 多酶级联催化技术及合成应用; 生物催化工程研究与工业示范

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Li H (李昊), Zhang GX, Li LM, Ou YS, Wang MY, Li CX, Zheng GW*, Xu JH* (2016). A novel (R)-imine reductase from Paenibacillus lactis for asymmetric reduction of 3H-indoles. ChemCatChem, http://dx.doi.org/10.1002/cctc.201501170. 2. Chen FF (陈飞飞), Liu YY, GW Zheng*, Xu JH*. Asymmetric amination of sec-alcohols using a redox-neutral two-enzyme cascade. ChemCatChem, 2015, 7: 3838-3841. (Highlighted by Nature Chemistry 2015, 7, 948) 3. Kong XD (孔旭东), Li L, Chen S, Yuan S, Zhou J*, Xu JH*. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci USA, 2014, 111: 15717–15722 4. Kong XD (孔旭东), Ma Q, Zhou JH*, Zeng BB*, Xu JH* (2014). A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-?-blocker precursors. Angew Chem Int Ed, 2014, 53: 6641–6644. 5. Ma BD (马宝娣), Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, Xu JH*. Increased catalyst productivity in α-hydroxy acids resolution by esterase mutation and substrate modification. ACS Catalysis, 2014, 4: 1026-1031. 6. Luo XJ (罗晓晶), Kong XD, Zhao J, Chen Q, Zhou JH*, Xu JH*. Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnology and Bioengineering, 2014, 111: 1920-1930. 7. Nguyen-Tran HH (阮陈孝辉), Zheng GW*, Qian XH, Xu JH*. Highly selective and controllable synthesis of aryl hydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitro reductase BaNTR1. Chemical Communications, 2014, 50: 2861?2864. 8. Zhang WX (张文霞), Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g L-1 d-1 using a new bacterial reductase ArQR. Organic Letters, 2013, 15: 4917?4919. 9. Xu GC (许国超), Yu HL*, Zhang ZJ, Xu JH*. Stereocomplementary bioreduction of β?ketonitrile without ethylated byproduct. Organic Letters, 2013, 15: 5408–5411. 10. Huang L (黄磊), Ma HM, Yu HL*, Xu JH*. Altering the substrate specificity of a reductase CgKR1 by protein engineering for bioreduction of aromatic ?-ketoesters. Advanced Synthesis and Catalysis, 2014, 356: 1943–1948.

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