周胜敏 - 华东理工大学 - 生物工程学院

个人简介

河北石家庄人，博士，副教授，生物反应器工程国家重点实验室固定成员。2009年3月取得东京大学博士学位。2009年4月至2014年8月先后在东京大学和日本筑波大学做博士后研究工作。2011年4月至 2013年3月期间任职日本学术振兴会(JSPS)特别研究员。2014年11月受聘于华东理工大学生物工程学院纳米生物工程实验室团队。入选上海市浦江人才（A类），华理青年英才引进与培育计划，生工学院优秀青年教师培育计划。主持国家自然科学基金面上项目，上海市浦江人才项目，国家重点实验室开放课题等多个项目。骨干参与科技部新药创制重大专项、国家重点研发计划（中日合作)，以第一作者身份在《自然》子刊Nature Chemical Biology等期刊上发表论文多篇。

研究领域

探索生物体内环境胁迫、信号传导，次级代谢调控，细胞凋亡等过程涉及的诸多功能基因，研究其作用机理，活用这些基因使之服务于工业、农业、医疗卫生等领域；以真菌为研究对象，从分子水平阐明其逃逸人体免疫杀菌系统进而感染人体的生物过程，同时挖掘致病因子，为新型抗真菌药物开发提供分子靶标；氧化应激及与之对应的信号传导、细胞凋亡与衰老等相关机制研究；产业化过程中工业微生物的集群效应(Quorum sensing)发生机制研究，开发集群效应基因模块，使之服务于绿色制造；真菌的基因编辑技术(CRISPR-Cas)的开发、基于纳米技术的生物探针的开发也是本课题组的重要研究方向。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Yang Y, Zhou Y, Li J, Yu H, Takaya N, Wang P, Zhou S*. Novel peroxiredoxin-based sensor for sensitive detection of hydrogen peroxide.Biochem. Biophys. Res. Commun. 517(2):260-265, 2019. 2. H Yu, H Li, C Chen, Zhou S*, P Wang*. Water-sensitive phase-transition of a carbon dot–calcium carbonate composite for moisture detection in organic solvents. Analytical Methods. 11, 2634-2638, 2019. 3. He H, Liu Y, Zhou Z, Guo C, Wang HY, Wang Z, Wang X, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*.A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications.FreeRadical Biology and Medicine.123: 1-7, 2018. 4. He H,Xia Y, Qi Y, Wang HY, Wang Z, Bao J, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*.A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications.Bioconjugate Chemistry.18;29(4):1194-1198, 2018. 5. Xia Y, Yu H, Zhou Z, Takaya N, Zhou S*, Wang P*.Peroxiredoxin system of Aspergillus nidulans resists inactivation by high concentration of hydrogen peroxide-mediated oxidative stress. Journal of Microbiology and Biotechnology.28(1): 145-156, 2018. 6. Yu H, Chen C, Cao X, Liu Y, Zhou S*, Wang P*.Ratiometric fluorescent pH nanoprobes based on in situ assembling of fluorescence resonance energy transfer between fluorescent proteins.Analytical and Bioanalytical Chemistry，409(21):5073-5080, 2017. 7. Zhou Y, Zhou S*, Yu H, Li J, Xia Y, Li B, Wang X, Wang P*.Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. 26 (5): 928-937, 2016. 8. Zhou S and Takaya N. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014. 9. Zhou S, Narukami T, Masuo S, Shimizu M, Fujita T, Doi Y, Kamimura Y, Takaya N.NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013. 10. Zhou S, Narukami T, Nameki M, Ozawa T, Kamimura Y, Hoshino T, Takaya N.Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012. 11. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Maruyama J, Kitamoto K, Wakagi T, Shoun H. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011. 12. Zhou S,Nakanishi Y, Kim SW, Fushinobu S, Maruyama J, Kitamoto K, Wakagi T, Shoun H. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010. 13. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Wakagi T, Shoun H.Aspergillus oryzaeflavohemoglobins promote oxidative damage by hydrogen peroxide. Biochem. Biophys. Res. Commun. 394(3):558-561, 2010. 14.Zhou S, Fushinobu S, Nakanishi Y, Kim SW, Wakagi T, Shoun H. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae. Biochem. Biophys. Res. Commun. 381 (1): 7-11, Jan, 2009. 15. Pang B, Zhou L, Cui W, Liu Z, Zhou S, Xu J, Zhou Z. A Hyperthermostable Type II Pullulanase from a Deep-Sea Microorganism Pyrococcus yayanosii CH1. J. Agric. Food. Chem. 67(34):9611-9617,2019 16. Shunsuke Masuo,AiriKomatsuzaki, Takeshita Norio, Eriko Itoh, Okazoe Takaaki, Shengmin Zhou, Naoki Takaya*. Spatial heterogeneity of glycogen and its metabolizing enzymes in Aspergillus nidulans hyphal tip cells. Fungal Genetics and Biology.110:48-55, 2018. 17. Shunsuke Masuo, Shengmin Zhou, Tatsuo Kaneko, Naoki Takaya*. Bacterialfermentation platform for producing artificial aromatic amines.Scientific Report, 11:6, 2016. 18. Motoyuki Shimizu, Shunsuke Masuo, Eriko Itoh, Shengmin Zhou, Masashi Kato, Naoki Takaya*. Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans.Bioscience, Biotechnology, and Biochemistry. 80(9), 1768-1775, 2016 19. Jia Wei, Xiaodan Cao,Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology.25(8): 1227-1233, 2015 20. Shunsuke Masuo, Lisa Osada,Shengmin Zhou, Tomoya Fujita,Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015. 21. Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura.Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1. Environmental Microbiology. 16(9):2927-2938,2014