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个人简介

1978年5月生,男,博士,华东理工大学生物工程学院,生物反应器工程国家重点实验室教授,硕士生导师。2012年入选国家鲆鲽类现代农业产业技术体系疾病防控岗位后备人才,2013年入选上海市科技启明星人才计划。2013.12-2014.12,美国哈佛医学院/霍华德·休斯医学研究院Matthew K. Waldor教授实验室访问学者。

研究领域

1. 采用系统生物学方法研究动物病原性细菌致病机制 2. 疫苗应用开发

近期论文

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1. Jingfan Xiao, Qiyao Wang*, Qin Liu, Lili Xu, Xin Wang, Haizhen Wu, and Yuanxing Zhang* Characterization of Edwardsiella tarda rpoS: effect on serum resistance, chondroitinase activity, biofilm formation, and autoinducer synthetases expression, Applied Microbiology and Biotechnology, 2009, 83:151-160. 2. Qiyao Wang, Minjun Yang, Jingfan Xiao, Haizhen Wu, Xin Wang, Yuanzhi Lv, Lili Xu, Huajun Zheng, Shengyue Wang, Guoping Zhao, Qin Liu, Yuanxing Zhang. Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches. PLoS ONE, 2009, 17, 4(10): e7646. 3. Xin Wang, Qiyao Wang*, Jingfan Xiao, Qin Liu, Haizhen Wu, Lili Xu, Yuanxing Zhang*. Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish & Shellfish Immunology, 2009, 27(3): 469-477. 4. Xin Wang, Qiyao Wang*, Minjun Yang, Jingfan Xiao, Qin Liu, Haizhen Wu, and Yuanxing Zhang*. QseBC controls flagellar motility, fimbrial hemagglutination and intracellular virulence in fish pathogen Edwardsiella tarda. Fish & Shellfish Immunology. 2011, 30: 944-953 5. Huan Liu,?Qiyao Wang*, Qin Liu, Xiaodan Cao, Cunbin Shi,?Yuanxing Zhang*. Roles of Hfq in the stress adaptation and virulence in fish pathogen Vibrio alginolyticus and its potential application as a target for live attenuated vaccine, Applied Microbiology and Biotechnology, 2011, 91:353-364 6. Jingfan Xiao, Tao Chen, Qiyao Wang*, Qin Liu, Xin Wang, Yuanzhi Lv, Haizhen Wu, and Yuanxing Zhang*. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda . Letters in Applied Microbiology. 2011, 53(4):430-437 7. Yamin Wang, Qiyao Wang*, Jingfan Xiao, Qin Liu, and Yuanxing Zhang. Genetic Relationships of Edwardsiella Strains Isolated in China Aquaculture Revealed by rep-PCR Genomic Fingerprinting and Investigation of Edwardsiella Virulence Genes. Journal of Applied Microbiology, 2011, 111(6): 1337-1348 (Q2) 8. Huan Liu, Dan Gu, Xiaodan Cao, Qin Liu, Qiyao Wang*, Yuanxing Zhang*. Characterization of a new quorum sensing regulator luxT and its roles in the extracellular protease production, motility and virulence in fish pathogen Vibrio alginolyticus. Archives of Microbiology. 2012, 194:439-452 (Q3) 9. Lili Sheng, Qiyao Wang*, Qin Liu, Yuanxing Zhang Connection between Type VI Secretion System, Quorum Sensing, and Alternative Sigma Factor in Fish Pathogen Vibrio alginolyticus. Archives of Microbiology, 2012, 194(5):379-390 10. Yuanzhi Lv, Jingfan Xiao, Qin Liu, Haizhen Wu, Yuanxing Zhang, Qiyao Wang*. Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Veterinary Microbiology. 2012, 157:190-199 11. Jingfan Xiao, Tao Chen, Qiyao Wang*, Yuanxing Zhang. Comparative analysis of the roles of catalases KatB and KatG in the physiological fitness and pathogenesis of fish pathogen Edwardsiella tarda. Letters in Applied Microbiology. 2012, 54, 425-432 (Q3) 12. Minjun Yang, Jingfan Xiao, Haizhen Wu, Yuanzhi Lv, Huajun Zheng, Qin Liu, Yuanxing Zhang, Qiyao Wang*. Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms. PLOS ONE. 2012, 7(5): e36987. 13. Jingfan Xiao, Xin Wang, Tao Chen, Yuanxing Zhang, Qiyao Wang*. Identification of qseEGF genetic locus and its roles in regulating hemolytic activity and invasion in fish pathogen Edwardsiella tarda. Letters in Applied Microbiology, 2012, 55(2):91-98 14. Huan Liu, Dan Gu, Lili Sheng, Qiyao Wang*, Yuanxing Zhang. Investigation of the roles of T6SS genes in motility, biofilm formation, and extracellular protease Asp production in Vibrio alginolyticus with modified Gateway-compatible plasmids. Letters in Applied Microbiology, 2012, 55:73-81 15. Yuanzhi Lv, Junyuan Zheng, Minjun Yang, Qiyao Wang*, Yuanxing Zhang. An Edwardsiella tarda mutant lacking UDP-glucose dehydrogenase shows pleiotropic phenotypes, attenuated virulence, and potential as a vaccine candidate. Veterinary Microbiology, 2012, 160: 506-512 16. Lili Sheng, Yuanzhi Lv, Qin Liu, Qiyao Wang*, Yuanxing Zhang. Connecting type VI secretion, quorum sensing, and c-di-GMP production in fish pathogen Vibrio alginolyticus through phosphatase PppA, Veterinary Microbiology, 2013, 162: 652-662 17. Yamin Wang, Weizheng Yang, Qiyao Wang*, Yuanxing Zhang. Functional characterization of Edwardsiella tarda twin-arginine translocation system and its potential use as a biological containment for live attenuated vaccine in marine fish vaccinology. Applied Microbiology and Biotechnology, 2013, 97(8): 3543-3557 18. Yamin Wang, Qiyao Wang*, Minjun Yang, Yuanxing Zhang. Proteomic analysis of a twin-arginine translocation deficient mutant unravel its functions involved in stress adaptation and virulence in fish pathogen Edwardsiella tarda. FEMS Microbiology Letters, 2013, 343:145-155. 19. Yuanzhi Lv, Kaiyu Yin, Shuai Shao, Qiyao Wang*, Yuanxing Zhang. Comparative proteomic analysis reveals new components of the PhoP regulon and highlights a role for PhoP in the regulation of genes encoding the F1F0 ATP synthase in Edwardsiella tarda, Microbiology-SGM, 2013, 159: 1340-1351. (Q2) 20. Jingfan Xiao, Tao Chen, Bin Liu, Weizheng Yang, Qiyao Wang*, Jiangbo Qu, Yuanxing Zhang. Edwardsiella tarda mutant disrupted in type III secretion system and chorismic acid synthesis and cured of a plasmid as a live attenuated vaccine in turbot. Fish & Shellfish Immunology, 2013, 35: 632-641. (Q1)

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