个人简介
2003-2007 华东理工大学，生物工程学院，博士
2000-2003 天津科技大学，生物工程学院，硕士
1996-2000 天津科技大学，食品工程系，学士
研究领域
利用代谢工程和合成生物学的原理和方法，致力于微生物细胞工厂的研究和开发，主要研究内容分为两块：一、针对工业微生物生产领域中的一些关键瓶颈问题，开展生理生化、组学、代谢工程和合成生物学研究，开发高效能微生物菌种。涉及的品种：甾体药物、营养补充剂和有机酸等。二、 针对动植物来源的高值活性天然产物和低产但高附加值的微生物次生代谢产物，开展微生物异源全合成研究。涉及品种：甾体型天然产物、中药活性天然产物、萜类香料和微生物次生代谢产物等
近期论文
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1. Li-Qin Xu, Yong-Jun Liu, Kang Yao, Hao-Hao Liu, Xin-Yi Tao, Feng-Qing Wang*, Dong-Zhi Wei. Unraveling and engineering the production of 23,24-bisnorcholenic steroids in sterol metabolism. Scientific Reports, 2016, 6:21928.
2. Xin-Bin Liu, Min Liu, Xin-Yi Tao, Zhong-Xi Zhang, Feng-Qing Wang*, Dong-Zhi Wei. Metabolic engineering of Pichia pastoris for the production of dammarenediol-II. Journal of biotechnology, 2015, 216: 47-55.
3. Kang Yao, Li-Qin Xu, Feng-Qing Wang*, Dong-Zhi Wei. Characterization and engineering of 3-ketosteroid-Δ1-dehydrogenase and 3-ketosteroid-9α-hydroxylase in Mycobacterium neoaurum ATCC 25795 to produce 9α-hydroxy-4-androstene-3,17-dione through the catabolism of sterols. Metabolic Engineering, 2014, 24: 181-191.
4. Hengwei Wang, Fengqing Wang, Wei Wang, Xueling Yao, Dongzhi Wei, Hairong Cheng, Zixin Deng. Improving the expression of recombinant proteins in E. coli BL21 (DE3) under acetate stress: an alkaline pH shift approach. Plos One. 2014, 9(11): e112777.
5. Kang Yao, Feng-Qing Wang*, Huai-Cheng Zhang, Dong-Zhi Wei. Identification and engineering of cholesterol oxidases involved in the initial step of sterols catabolism in Mycobacterium neoaurum. Metabolic Engineering, 2013, 15:75-87.
6. Wei Wei, Shu-Yue Fan, Feng-Qing Wang*, Dong-Zhi Wei. Accumulation of androstadienedione by overexpression of heterologous 3-ketosteroid-C1-dehydrogenase in Mycobacterium neoaurum NwIB-01. World Journal of Microbiology and Biotechnology. 2014, 30: 1947-1954.
7. Miao-Miao Chen, Feng-Qing Wang*, Liang-Cai Lin, Kang Yao, Dong-Zhi Wei. Characterization and application of fusidane antibiotic biosynethsis enzyme 3-ketosteroid-?1-dehydrogenase in steroid transformation. Applied Microbiology and Biotechnology, 2012, 96:133-142.
8. Hengwei Wang, Fengqing Wang, Xinyi Tao Hairong Cheng. Ammonia-containing DMSO: An improved solvent for the dissolution of formazan crystals in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Analytical Biochemistry, 2012, 421:324-326.
9. Liangcai Lin, Weiguo Fang, Xinggang Liao, Fengqing Wang, Dongzhi Wei, Raymond J. St. Leger. The MrCYP52 cytochrome P450 monoxygenase gene of Metarhizium robertsii is important for utilizing insect epicuticular hydrocarbons. PloS One. 2011, 6(12) e28984.
10. Liangcai Lin, Fengqing Wang*, Dongzhi Wei. Chlorimuron ethyl as a new selectable marker for disrupting genes in the insect-pathogenic fungus Metarhizium robertsii. Journal of Microbiological Methods, 2011, 87:241-243.
11. Feng-Qing Wang, Kang Yao, Dongzhi Wei. From soybean phytosterols to steroid hormones. In Hany A. EI-Shemy (ed.) Soybean and Health. Intech, 2011, P231-252.
12. Hengwei Wang, Hairong Cheng, Dongzhi Wei, Fengqing Wang*. Comparison of methods for measuring viable E. coli cells during cultivation: Great differences in the early and late exponential growth phases. Journal of Microbiological Methods, 2011, 84:140-143.
13. Wei Wei, Fengqing Wang*, Shu-yue Fan, Dong-zhi Wei. Inactivation and augmentation of the main 3-ketosteroid- 1-dehydrogenase in Mycobacterium neoaurum NwIB-01: biotransformation of soybean phytosterols to 4-androstene-3,17-dione or 1,4-androstadiene-3,17-dione. Applied and Environmental Microbiology, 2010, 76:4578-4582.
14. Wei Wei, Shuyue Fan, Fengqing Wang*, Dongzhi Wei. A new steroid-transforming strain of Mycobacterium neoaurum and cloning of 3-ketosteroid 9α-hydroxylase in NwIB-01. Applied Biochemistry and Biotechnology. 2010, 162:1446-1456.
15. Bo Li, Wei Wang, Feng-Qing Wang*，Dong-Zhi Wei. Cholesterol oxidase ChoL is a critical enzyme that catalyzes the conversion of diosgnin to 4-ene-3-keto steroids in Streptomyces virginiae IBL-14. Applied Microbiology and Biotechnology, 2010, 85:1831-1838.
16. HengWei Wang, Fengqing Wang, Dongzhi Wei. Impact of oxygen supply on rtPA expression in Escherichia coli BL21 (DE3): ammonia effects. Applied Microbiology and Biotechnology, 2009, 82:249-259.
17. Feng-Qing Wang, Cheng-Gang Zhang, Bo Li, Dong-Zhi Wei, Wang-Yu Tong. New microbiological transformations of steroids by Streptomyces virginiae IBL-14. Environmental Science & Technology. 2009, 43:5967-5974.
18. Wei Wang, Feng-Qing Wang, Dong-Zhi Wei. Characterization of P450 FcpC, the enzyme responsible for bioconversion of diosgnone to isonuatigenone in Streptomyces virginiae IBL-14. Applied and Environmental Microbiology. 2009, 75:4202-4205.
19. Feng-Qing Wang, Bo Li, Wei Wang, Cheng-Gang Zhang, Dong-Zhi Wei. Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14. Applied Microbiology and Biotechnology. 2007, 77:771-777.
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