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个人简介

教育经历 2002/9-2006/7,苏州大学,学士 2006/9-2011/7:中国科学院海洋研究所, 博士 工作经历 2011/9-2014/9:研究助理,英国布里斯托大学化学系 2014/11-2017/6:博士后研究员,加州大学洛杉矶分校化学与生物分子工程系 2017/9-2018/1:教授,湖南大学化学化工学院 2018/2-:项目研究员,中国科学院微生物研究所 获奖情况 中国科学院院长优秀奖(2011年)

研究领域

真菌天然产物生物合成、临床化学药物分子的酶工程化、生物合成酶的合成生物学研究

近期论文

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Yongpeng Yao, Chunyan An, Declan Evans, Weiwei Liu, Wei Wang, Guangzheng Wei, Ning Ding, K. N. Houk,*, Shu-Shan Gao.* A Catalase Involved in the Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids. Journal of the American Chemical Society, 2019, In press. Mengbin Chen, Qikun Liu, Shu-Shan Gao, Abbegayle E. Young, Steven E. Jacobsen, and Yi Tang. Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant. PNAS, 2019 116 (12) 5499-5504. Link Tingting Hao, Zhoujie Xie, Min Wang, Liwei Liu, Yuwei Zhang, Weicang Wang, Zhao Zhang, Xuejin Zhao, Pengwei Li, Zhengyan Guo, Shushan Gao, Chunbo Lou, Guodong Zhang, Justin Merritt, Geoff P. Horsman & Yihua Chen, An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters, Nature Communicationsvolume, 2019, Doi: doi.org/10.1038/s41467-019-11673-0 Link Li Li, Man-Cheng Tang, Shoubin Tang, Shu-Shan Gao, sameh.S.M soliman, Leibniz Hang, Wei Xu, Tao Ye, Kenji Watanabe, and Yi Tang. Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society, 2018, 140, 2067-2071. Link Shu-Shan Gao#, Tao Zhang#, Marc Garcia-Borràs, Yiu-Sun Hung§, John M. Billingsley, K. N. Houk*, Youcai Hu*, and Yi Tang*, Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide, Journal of the American Chemical Society, 2018, 140, 6991-6997.Link Shu-Shan Gao,# Ronghai Cheng,# Nathchar Naowarojna,# Xueting Liu,* and Pinghua Liub,* Recent Examples of α-Ketoglutarate Dependent Mononuclear Non-Haem Iron Enzymes in Natural Product Biosyntheses. Natural Product Reports, 2018, 35, 792-837. Link Shu-shan Gao,# Luoyi Wang,# Zhongshu Song, Joanne Hothersall, Russell J. Cox, Matthew P. Crump, Paul Race, Christopher M. Thomas, Christine L. Willis* and Thomas J. Simpson* Selected Mutations Reveal New Intermediates in the Biosynthesis of the Thiomarinols and Mupirocin Antibiotics, Angewandte Chemie International Edition, 2017, 56, 3930−3934 . Link Shu-Shan Gao, Marc Garcia-Borràs, Joyann S. Barber, Yang Hai, Abing Duan, Neil K. Garg, K. N. Houk, Yi Tang§, Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation. Journal of the American Chemical Society, 2017, 139, 3639–3642. Link Michio Sato, Jacob E Dander, Chizuru Sato, Yiu-sun Hung, Shu-Shan Gao, Man-Cheng Tang, Leibniz Hang, Jaclyn M Winter, Neil K Garg, Kenji Watanabe, Yi Tang. Collaborative Biosynthesis of Maleimide-and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases. Journal of the American Chemical Society, 2017, 139, 5317−5320. Link Nicholas Liu, Yiu-Sun Hung, Shu-Shan Gao, Leibniz Hang, Yi Zou, Yit-Heng Chooi, and Yi Tang. Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Organic Letters, 2017, 19, 3560–3563. Link Shu-Shan Gao, Xiao-Ming Li, Katherine Williams, Peter Proksch, Nai-Yun Ji, and Bin-Gui Wang. Rhizovarins A–F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. Journal of Natural Products, 2016, 79, 2066−2074. Link Shu-Shan Gao, Abing Duan, Wei Xu, Peiyuan Yu, Leibniz Hang, K. N. Houk, Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase. Journal of the American Chemical Society 2016, 138, 4249–4259. Link Li Li, Peiyuan Yu, Man-Cheng Tang, Yi Zou, Shu-Shan Gao, Yiu-Sun Hung, Muxun Zhao, Kenji Watanabe, Kendall N Houk, Yi Tang. Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase. Journal of the American Chemical Society, 2016, 138, 15837−15840. Link Shu-Shan Gao,# Joanne Hothersall,# Ji’en Wu, Annabel C. Murphy, Zhongshu Song, Elton R. Stephens, Christopher M. Thomas, Russell J. Cox, Thomas J. Simpson, and Christine L. Willis. The Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways, Journal of the American Chemical Society, 2014, 136, 5501−5507. Link Annabel C. Murphy#, Shu-Shan Gao#, Li-Chen Han, Daisuke Fukuda, Zhongshu Song, Joanne Hothersall, Simon Carobene, Russell J. Cox, John Crosby, Christine L. Willis, Christopher M. Thomas and Thomas J. Simpson, Biosynthesis of Thiomarinol A and Related Metabolites of Pseudoalteromonas SANK73390. Chemical science, 2014, 5, 397−402. Link Shu-Shan Gao, Xiao-Ming Li, Yi Zhang, Chun-Shun Li, Chuan-Ming Cui, and Bin-Gui Wang. Comazaphilones A-F, azaphilone derivatives from the marine sediment-derived fungusPenicillium commune QSD-17. Journal of Natural Products, 2011 ,74, 256−261. Shu-Shan Gao, Xiao-Ming Li, Feng-Yu Du, Chun-Shun Li, Peter Proksch and Bin-Gui Wang. Secondary metabolites from a marine-derived endophytic fungus Penicillium chrysogenum QEN-24S. Marine Drugs, 2011, 9, 59−70. Shu-Shan Gao, Xiao-Ming Li, Chun-Shun Li, Peter Proksch, and Bin-Gui Wang. Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S. Bioorganic & Medicinal Chemistry Letters, 2011, 27, 2894−2897. Shu-Shan Gao, Xiao-Ming Li, Yi Zhang, Chun-Shun Li and Bin-Gui Wang. Conidiogenones H and I, two new diterpenes of cyclopiane class from a marine-derived endophytic fungus Penicillium chrysogenum QEN-24S. Chemistry & Biodiversity, 2011, 8, 1748−1753. Shu-Shan Gao, Zhuo Shang, Xiao-Ming Li, Chun-Shun Li, Chuan-Ming Cui and Bin-Gui Wang, Secondary Metabolites Produced by Solid Fermentation of the Marine-Derived Fungus Penicillium commune QSD-17. Bioscience, Biotechnology, and Biochemistry. 2012, 76, 358−360. Shu-Shan Gao, Xiao-Ming Li and Bin-Gui Wang. Perylene derivatives produced by Alternaria alternata, an endophytic fungus isolated from Laurencia Species. Natural Product Communications, 2009, 4, 1477−1480.

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