张士磊 - 苏州大学 - 医学部药学院

个人简介

1998.9-2002.7：中国海洋大学化学化工学院海洋化学专业，大学本科 2002.9-2007.7：中国科学院上海药物研究所，药物化学，博士学位 2007.7-2008.9：华东理工大学药学院药物化学系，讲师 2008.10-2012.1：美国新墨西哥大学(University of New Mexico)，有机化学，博士后 2012.2-至今：苏州大学医学部药学院，教授

研究领域

（1）化学方法学、手性药物研究（2）制药工艺过程研究及杂质研究（3）抗癌药物和抗菌药物研究

近期论文

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1) Jiang, J.; Cai, X.; Hu, Y.; Liu, X.; Chen, X.; Wang, S.; Zhang, Y.; Zhang, S.* “Thermo-promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols and Malononitrile under Catalyst-free Conditions” J. Org. Chem. 2019, 84 (4), 2022-2031. 2) Liu, Y.; Mao, Y.; Hu, Y.; Gui, J.; Wang, L.; Wang, W.;Zhang, S.* “The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds” Adv. Synth. Catal.,2019, 361, DOI:10.1002/adsc.201801676. 3) Mao, Y.; Liu, Y.; Hu, Y.; Wang, L.; Zhang, S.;* Wang, W. “Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium Hydride” ACS catal., 2018, 8, 3016-3020. 4) Jiang, J.; Hu, Y.; Cai, X.; Wang, L.; Hu, Y.; Chen, S.; Zhang, S.; Zhang, Y. “Bis(phenylsulfonyl)methane mediated synthesis of olefins via a halogen elimination and double bond migration” Org. Biomol. Chem., 2018,16, accepted. 5) Yang, J.; Qiu, G.; Jiang, J.; Hu, Y.;* Chen, S.; Zhang, S.;* Zhang Y. “Asymmetric Organocatalytic Synthesis of Benzopyran- andBenzofuran-Fused Polycyclic Acetals” Adv. Synth. Catal.,2017, 359, 2184-2190. 6) Qian, P; Wan, H; Jiang, J; Hu, Y; Chen, X;*Zhang S.-L.;*“Discovery of a Special Intramolecular Aldol-Like Reaction in the Synthesis of Related Substance E of Tadalafil” Chin. J. Org. Chem. 2016, 36, 1878-1882. 7) Xie, R.; Hu, Y.; Wan, H.; Hu, Y.; Chen, S.; Zhang, S.;* Zhang, Y.“An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acyetylene amine” Tetrahedron Lett.2016, 57, 2418-2421. 8) Chen, X.; Zhang, Y.; Wan, H.; Wang, W.; Zhang, S.* “Stereoselective organocatalytic oxidation of alcohols to enals: a homologation method to prepare polyenes” Chem. Commun., 2016,3532-3535. 9) Wang, J.; Qian, P.; Hu, Y.; Yang, J.; Jiang, J.; Chen, S.; Zhang, Y.; Zhang, S.* “Organocatalytic aldol addition reaction of cyclic hemiacetals to aldehydes” Tetrahedron Lett.2015, 56, 2875-2877. 10) Liu, S.; Hu, Y.; Qian, P.; Hu, Y.; Ao, G.; Chen, S.; Zhang, S.;* Zhang, Y.“An efficient cascade approach to dibenzoxazepinones via nucleophilic aromatic substitution and Smiles rearrangement” Tetrahedron Lett.2015, 56, 2211-2213. 11) Liu, S.; Zhu, S.; Wu, Y.; Gao, J.; Qian, P.; Hu, Y.; Shi, L.; Chen, S.;Zhang, S.;*Zhang, Y.“One-pot synthesis of N-aryl-nicotinamides and diaryl-amines based on a tunable Smiles rearrangement” Eur. J. Org. Chem., 2015, 3048-3052. 12) Zhu, Y.; Qian, P.; Yang, J.; Chen,S.; Hu, Y.; Wu, P.; Wang, W.; Zhang, W.; Zhang, S.* “Organocatalytic Enantioselective Michael Addition of Cyclic Hemiacetals to Nitroolefins: A Facile Access to Chiral Substituted 5- and 6-Membered Cyclic Ethers” Org. Biomol. Chem., 2015,13, 4769-4775. 13) Liu, S.; Chen, X.; Hu, Y.; Yuan, L.; Chen, S.; Wu, P.; Wang, W.; Zhang, S.;* Zhang W. “An Efficient Method for the Production of Terminal Alkynes from 1,1-Dibromo-1-alkenes and its Application in the Total Synthesis of Natural Product Dihydroxerulin” Adv. Synth. Catal.,2015, 357, 553-560