Lu, Yixin - National University of Singapore - Department of Chemistry, Faculty of Science

个人简介

Prof. Yixin Lu studied chemistry and received his B.Sc. from Fudan University, and continued his graduate studies in Canada and obtained his Ph.D. in Organic Chemistry under the supervision of George Just from McGill University in 2000. He then carried out his postdoctoral research with Peter W. Schiller at Clinical Research Institute of Montreal, and subsequently worked as an RCMS fellow with Ryoji Noyori at Nagoya University. In late 2003, he started his independent research and joined the National University of Singapore (NUS) where he is now a Professor. Currently, he is the Head of NUS Chemistry Department, a Fellow of Singapore National Academy of Science, and the Vice-President of Singapore National Institute of Chemistry (SNIC). He was the recipient of a number of awards, including Asian Core Program (ACP) Lectureship Awards to China, Japan, Korea and Taiwan (2009 2016); Young/Outstanding Scientist Award from the Faculty of Science, NUS (2009, 2013); GSK-SNIC Award in Organic Chemistry (2013); Dean’s Chair Professorship (2013); NRF Investigatorship Award (2018). He is an Editorial Advisory Board Member for Accounts of Chemical Research, an Editorial Board Member for Asian Journal of Organic Chemistry, and an Associate Editor for Green Synthesis and Catalysis. His research program is focused on asymmetric catalysis and synthesis, and his current interests include organic catalysis, transition metal catalysis, and photoredox catalysis, and sustainable chemistry.

研究领域

ASYMMETRIC CATALYSIS AND SYNTHESIS Amino catalysis promoted by primary amino acids/amines Amino acid-derived novel tertiary amine-thiourea bifunctional catalysts Novel amino acid-incorporating multifunctional catalysts Novel bifunctional phosphines derived from amino acids/peptides MEDICINAL CHEMISTRY

近期论文

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Qi, L.-W.; Rogge, T.; Houk, K. N.; Lu, Y. “Iridium-nitrenoid enabled arene C-H functionalization”, Nat. Catal. 2024, 7. Doi: 10.1038/s41929-024-01207-3. Zheng, W., Tan, B. B., Ge, S., & Lu, Y. Enantioselective Copper-Catalyzed Ring-Opening Diboration of Arylidenecyclopropanes to Access Chiral Skipped 1, 4-and 1, 3-Diboronates. J. Am. Chem. Soc. 2024, 146, 5366-5374. Zhou, X.; Huang, Q.; Guo, J.; Dai, L.; Lu, Y., “Enantioselective De Novo Synthesis of α,α-Diaryl Ketones from Alkynes”, Angew. Chem. Int. Ed. 2023, e202310078. Zhou, X.; Huang, Q.; Guo, J.; Dai, L.; Lu, Y., Molecular editing of pyrroles via a skeletal recasting strategy. ACS Cent. Sci. 2023, 9, DOI: 10.1021/acscentsci.3c00812. Dai L.; Zhou, X.; Guo, J.; Dai, X.; Huang, Q.; Lu, Y. “Diastereo- and atroposelective synthesis of N-Arylpyrroles enabled by light-induced phosphoric acid catalysis”, Nat. Commun. 2023, 14, 4813. Wu, Z.; Wu, M.; Zhu, K.; Wu, J.; Lu, Y. “Photocatalytic coupling of electron-deficient alkenes using oxalic acid as a traceless linchpin”, Chem 2023, 9, xxxx. Tan, C. X. A.; Li, R.; Zhang, F.; Dai, L.; Ullah, N.; Lu, Y. “Synthesis of axially chiral CF3-substituted 2-arylpyrroles by sequential phosphine-catalysed asymmetric [3+2] annulation and oxidative central-to-axial chirality transfer”, Angewandte Chemie, 2022, e202209494. Huang, Q.; Chen, Y.; Zhou, X.; Dai, L.; Lu, Y. “Nickel-hydride-catalyzed diastereo- and enantioselective hydroalkylation of cyclopropenes”, Angew. Chem. Int. Ed. 2022, e202210560. Dai, L.; Guo, J.; Huang, Q.; Lu, Y., Asymmetric multifunctionalization of alkynes via photo-irradiated organocatalysis. Sci. Adv. 2022, 8, eadd2574. Mei, G.-J.; Koay, W. L.; Guan, C.Y.; Lu, Y., Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis. Chem 2022, 8, 1855. Zhang, F.; Dai, X.; Dai, L.; Zheng, W.; Chan, W.-L.; Tang, X.; Zhang, X.; Lu, Y., Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines. Angew. Chem. Int. Ed. 2022, 61, e202203212. Chen Y.; Zhu, K.; Huang, Q.; Lu, Y. “Regiodivergent Sulfonylarylation of 1,3-Enynes via Nickel/Photoredox Dual Catalysis”, Chem. Sci. 2021, 12, 13564. Mei, G.-J.; Wong, J. J.; Zheng, W.; Nangia, A. A.; Houk, K. N.; Lu, Y. “Rational Design and Atroposelective Synthesis of N–N Axially Chiral Compounds”, Chem 2021, 7, 2743. Chen Y.; Wang, J.; Lu, Y. “Decarboxylative 1,4-Carbocyanation of 1,3-Enynes to Access Tetra-substituted Allenes via Copper/Photoredox Dual Catalysis”, Chem. Sci. 2021, 12, 11316. Wang, N.; Wu, Z.; Wang, J.; Ullah, N.; Lu, Y. “Recent Applications of Asymmetric Organocatalytic Annulation Reactions in Natural Products Synthesis”, Chem. Soc. Rev. 2021, 50, 9766. Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X. “Concise, scalable and enantioselective total synthesis of prostaglandins‘, Nat. Chem. 2021, 13, 692. Mei, G.-J.; Koay, W. L.; Tan, C. X. A.; Lu, Y. “Catalytic asymmetric preparation of pyrroloindolines: strategies and applications to total synthesis”, Chem. Soc. Rev. 2021, 50, 5985. Tang, X.; Tan, C. X. A.; Chan, W.-L.; Zhang, F.; Zheng, W.; Lu, Y. “Dielectrophilic Allenic Ketone-Enabled [4 + 2] Annulation with 3,3’-Bisoxindoles: Enantioselective Creation of Two Contiguous Quaternary Stereogenic Centers”, ACS Catal. 2021, 11, 1361. Bai, X.; Wu, C.; Ge, S.; Lu, Y. “Pd/Cu-Catalyzed Enantioselective Sequential Heck-Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers Centers”, Angew. Chem. Int. Ed., 2020, 59, 2764. DOI: 10.1002/anie.201913148. Mei, G.-J.; Tang, X.; Tasdan, Y.; Lu, Y. “ Enantioselective Dearomatization of Indoles via an Azoalkene-enabled (3+2) Reaction: Facile Access to Pyrroloindolines”, Angew. Chem. Int. Ed. 2020, 59, 648. Wu, M.; Han, Z.; Li, K.; Wu, J.; Ding, K. Lu, Y. “Cyclohexyl-Fused, Spirobiindane-derived, Phosphine-catalyzed Synthesis of Tricyclic γ-Lactams and Kinetic Resolution of γ-Substituted Allenoates”, J. Am. Chem. Soc., 2019, 141, 16362. Chan, W.-L.; Tang, X.; Zhang, F.; Quek, G.; Mei, G.-J.; Lu, Y. “Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers”, Angew. Chem. Int. Ed. 2019, 58, 6260 (a VIP paper). Li, K.; Gonçalves, T. P.; Huang, K.-W.; Lu, Y. “Dearomatization of 3-Nitroindoles by a Phosphine-catalyzed Enantioselective [3+2] Annulation Reaction”, Angew. Chem. Int. Ed. 2019, 58, 5427. Ni, H.; Chan, W.-L.; Lu, Y. “Phosphine-catalyzed Asymmetric Organic Reactions”, Chem. Rev. 2018, 118, 9344. (One of the top 3 most read articles in Chemical Reviews in September/October 2018). Ni, H.; Tang, X.; Zheng, W.; Yao, W.; Ullah, N.; Lu, Y. “Enantioselective Phosphine-Catalyzed Formal [4+4] Annulation of a,b-Unsaturated Imines and Allene Ketones: Construction of Eight-membered Rings”, Angew. Chem. Int. Ed. 2017, 56, 14222 (highlighted in SYNFACTS 2018, 89).