Bhatia, Sangeeta - Massachusetts Institute of Technology - Marble Center for Cancer Nanomedicine

个人简介

Sangeeta is a biomedical researcher, MIT professor, and biotech entrepreneur who works to adapt technologies developed in the computer industry for medical innovation. Trained as both a physician and engineer at Harvard, MIT, and Brown University, Bhatia leverages ‘tiny technologies’ of miniaturization to yield inventions such as human microlivers that model human drug metabolism and liver disease, as well as responsive nanoparticles and nanoporous materials that can be engineered to diagnose, study, and treat a variety of diseases, including cancer. She and her trainees have launched multiple biotechnology companies to improve human health. As a prolific inventor and passionate advocate for diversity in science and engineering, Bhatia has received many honors including the Lemelson-MIT Prize, known as the ‘Oscar for inventors,’ and the Heinz Medal for groundbreaking inventions and advocacy for women in STEM fields. She is a Howard Hughes Medical Institute Investigator, the Director of the Marble Center for Cancer Nanomedicine at the Koch Institute for Integrative Cancer Research at MIT, and an elected member of the National Academy of Sciences, the National Academy of Engineering, the American Academy of Arts and Science, the National Academy of Inventors, and Brown University's Board of Trustees. Education M.D., Harvard Medical School Ph.D., Medical Engineering, Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology M.S., Mechanical Engineering, Massachusetts Institute of Technology B.S., Biomedical Engineering, Brown University Affiliations Broad Institute of MIT and Harvard MIT Ludwig Center for Molecular Oncology Brigham & Women’s Hospital, Department of Medicine Wyss Institute for Biologically Inspired Engineering Harvard Stem Cell Institute MIT Appointments 2016 - present: Director, Marble Center for Cancer Nanomedicine 2009 - present: Investigator, Howard Hughes Medical Institute 2008 - present: Wilson Professor, Institute for Medical Engineering and Science 2008 - present: Wilson Professor, Electrical Engineering and Computer Science 2007 - present: Intramural Member, Koch Institute for Integrative Cancer Research

研究领域

Understanding the Tissue Microenvironment with Tiny Technologies Human tissues are composed of mixtures of cells that cooperate in a healthy microenvironment to perform the necessary functions of that organ. In contrast, altered microenvironments are a hallmark of disease. While cell-specific processes such as those controlled by a cell's genes certainly influence the balance between health and disease, our focus is on interactions between cells and their microenvironment that occur on the length scales of receptor interactions (10 nm) to multicellular interactions (100 µm). We leverage engineering tools that have been created by the semiconductor community to speed rates of computation through miniaturized manufacturing capabilities. These micro-and nanotechnology tools, by virtue of their spatial resolution, enable the precise synthesis, interrogation, and perturbation of tissue microenvironments. Thus, we aim to dissect the role of the tissue microenvironment in both health and disease using engineering tools. Specifically, we focus on tissue microenvironments of clinical importance in liver biology and cancer, and we seek to translate our findings into new therapies for patients.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

M. - E. Gilles, Hao, L., Brown, K., Lim, J., Bhatia, S. N., and Slack, F. J., “Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer”, Oncotarget, vol. 10, no. 51, 2019. PDF icon Manuscript, PDF icon Supporting information C. N. Loynachan†, Soleimany, A. P. †, Dudani, J. S., Lin, Y., Najer, A., Bekdemir, A., Chen, Q., Bhatia, S. N. ‡, and Stevens, M. M. ‡, “Renal clearable catalytic gold nanoclusters for in vivo disease monitoring”, Nature Nanotechnology, 2019. PDF icon Manuscript, PDF icon Supporting information S. Schuerle, Soleimany, A. P., Yeh, T., Anand, G. M., berli, Mä, Fleming, H. E., Mirkhani, N., Qiu, F., Hauert, S., Wang, X., Nelson, B. J., and Bhatia, S. N., “Synthetic and living micropropellers for convection-enhanced nanoparticle transport”, Science Advances, vol. 5, no. 4, p. eaav4803, 2019. PDF icon Manuscript, PDF icon Supporting Information K. Werling, W. Shaw, R., Itoe, M. A., Westervelt, K. A., Marcenac, P., Paton, D. G., Peng, D., Singh, N., Smidler, A. L., South, A., Deik, A. A., Mancio-Silva, L., Demas, A. R., March, S., Calvo, E., Bhatia, S. N., Clish, C. B., and Catteruccia, F., “Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles”, Cell, vol. 177, no. 2, pp. 315 - 325.e14, 2019. PDF icon Manuscript, PDF icon Supporting Information N. Rohani, Hao, L., Alexis, M. S., Joughin, B. A., Krismer, K., Moufarrej, M. N., Soltis, A. R., Lauffenburger, D. A., Yaffe, M. B., Burge, C. B., Bhatia, S. N., and Gertler, F. B., “Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes”, Cancer Research, 2019. PDF icon Manuscript, PDF icon Supporting Information L. Mancio-Silva, Fleming, H. E., Miller, A. B., Milstein, S., Liebow, A., Haslett, P., Sepp-Lorenzino, L., and Bhatia, S. N., “Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers”, Cell Metabolism, vol. 29, no. 3, pp. 727 - 735.e3, 2019. PDF icon Manuscript, PDF icon Supporting Information A. Amini†, Soleimany, A. †, Schwarting, W., Bhatia, S. N., and Rus, D., “Uncovering and Mitigating Algorithmic Bias through Learned Latent Structure”, AAAI/ACM Conference on Artificial Intelligence, Ethics, and Society, 2019. PDF icon Manuscript S. Chaturantabut, Shwartz, A., Evason, K. J., Cox, A. G., Labella, K., Schepers, A. G., Yang, S., Aravena, M., Houvras, iv, Y., Mancio-Silva, L., Romano, S., Gorelick, D. A., Cohen, D. E., Zon, L. I., Bhatia, S. N., North, T. E., and Goessling, W., “Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes”, Gastroenterology, 2019. PDF icon Manuscript J. Kirkpatrick, Warren, A. D., Tammela, T., Westcott, P. M. K., Voog, J. C., Jacks, T., and Bhatia, S. N., “Noninvasive lung cancer detection via pulmonary protease profiling”, bioRxiv, 2018. PDF icon Manuscript C. G. Buss†, Dudani, J. S. †, Akana, R. T. K., Fleming, H. E., and Bhatia, S. N., “Protease activity sensors noninvasively classify bacterial infections and antibiotic responses”, EBioMedicine, vol. 38, pp. 248-256, 2018. PDF icon Manuscript, PDF icon Supporting information A. M. Mendes, Machado, M., alves-Rosa, Nç, Reuling, I. J., Foquet, L., Marques, áudia, Salman, A. M., Yang, A. S. P., Moser, K. A., Dwivedi, A., Hermsen, C. C., nez-Díaz, éné, Viera, S., Santos, J. M., Albuquerque, ês, Bhatia, S. N., Bial, J., Angulo-Barturen, ñigo, Silva, J. C., Leroux-Roels, G., Janse, C. J., Khan, S. M., Mota, M. M., Sauerwein, R. W., and Prudêncio, M., “A Plasmodium berghei sporozoite-based vaccination platform against human malaria”, npj Vaccines, vol. 3, 2018. PDF icon Manuscript, PDF icon Supporting information J. S. Dudani, Ibrahim, M., Kirkpatrick, J., Warren, A. D., and Bhatia, S. N., “Classification of prostate cancer using a protease activity nanosensor library.”, Proc Natl Acad Sci U S A, vol. 115, no. 36, pp. 8954-8959, 2018. PDF icon Manuscript, PDF icon Supporting information J. H. Lo†, Hao, L. †, Muzumdar, M. D., Raghavan, S., Kwon, E. J., Pulver, E. M., Hsu, F., Aguirre, A. J., Wolpin, B. M., Fuchs, C. S., Hahn, W. C., Jacks, T., and Bhatia, S. N., “iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer”, Molecular Cancer Therapeutics, vol. 17, no. 11, pp. 2377-2388, 2018. PDF icon Manuscript, PDF icon Supporting information S. R. Viswanathan, Nogueira, M. F., Buss, C. G., Krill-Burger, J. M., Wawer, M. J., Malolepsza, E., Berger, A. C., Choi, P. S., Shih, J., Taylor, A. M., Tanenbaum, B., Pedamallu, C. Sekhar, Cherniack, A. D., Tamayo, P., Strathdee, C. A., Lage, K., Carr, S. A., Schenone, M., Bhatia, S. N., Vazquez, F., Tsherniak, A., Hahn, W. C., and Meyerson, M., “Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer”, Nature Genetics, vol. 50, no. 7, pp. 937 - 943, 2018. PDF icon Manuscript, PDF icon Supporting information N. K. Kisalu†, Idris, A. H. †, Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. - X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A., Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., S Farney, K., Chuang, G. - Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., B Sim, K. Lee, Hoffman, S. L., Zavala, F., Pancera, M. ‡, and Seder, R. A. ‡<, “A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite”, Nature Medicine, vol. 24, no. 4, pp. 408-416, 2018. PDF icon manuscript, PDF icon Supporting information N. Gural, Mancio-Silva, L., Miller, A. B., Galstian, A., Butty, V. L., Levine, S. S., Patrapuvich, R., Desai, S. P., Mikolajczak, S. A., Kappe, S. H. I., Fleming, H. E., March, S., Sattabongkot, J., and Bhatia, S. N., “In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites”, Cell Host & Microbe, vol. 23, no. 3, pp. 395-406, 2018. PDF icon Manuscript, PDF icon Supporting information M. - E. Gilles, Hao, L., Huang, L., Rupaimoole, R., Lopez-Casas, P. P., Pulver, E., Jeong, J. Cheol, Muthuswamy, S. K., Hidalgo, M., Bhatia, S. N., and Slack, F. J., “Personalized RNA-medicine for pancreatic cancer”, Clinical Cancer Research, vol. 24, no. 7, pp. 1734-1747, 2018. PDF icon Manuscript N. Gural, Mancio-Silva, L., He, J., and Bhatia, S. N., “Engineered Livers for Infectious Diseases”, Cellular and Molecular Gastroenterology and Hepatology, vol. 5, no. 2, pp. 131 - 144, 2018. PDF icon Manuscript.pdf J. S. Dudani, Warren, A. D., and Bhatia, S. N., “Harnessing Protease Activity to Improve Cancer Care”, Annual Review of Cancer Biology, vol. 2, no. 1, 2018. PDF icon manuscript.pdf Y. Ren, Sagers, J. E., Landegger, L. D., Bhatia, S. N., and Stankovic, K. M., “Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas”, Scientific Reports, vol. 7, no. 1, 2017. PDF icon Manuscript, PDF icon Supporting information