Sharpless, K. Barry - The Scripps Research Institute

个人简介

education and training Ph.D. in Chemistry, Stanford University , with Dr. Eugene van Tamelen 1968 B.A. in Chemistry, Dartmouth College , with Dr. Thomas A. Spencer 1963 awards and honors Priestley Medal, conferred by American Chemical Society, 2019 Nobel Prize in Chemistry, conferred by The Nobel Foundation, 2001 Member (National Academy of Sciences), conferred by National Academy of Sciences, 1985 Positions 2002 - Visiting Professor, Kitasato University 1996 - Member, The Skaggs Institute for Chemical Biology , Scripps Research 1990 - W.M. Keck Professor of Chemistry, Chemistry , Scripps Research 1990 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research 1987 - 1990 Arthur C. Cope Professor, Massachusetts Institute of Technology 1980 - 1990 Professor of Chemistry, Massachusetts Institute of Technology 1977 - 1980 Professor of Chemistry, Stanford University 1970 - 1977 Assistant Professor of Chemistry, Massachusetts Institute of Technology

研究领域

Dr. K. Barry Sharpless discovers new and useful transformations for organic synthesis, particularly employing inorganic catalysts and olefin-derived compounds of high reactivity; he also applies "in situ" click chemistry, which makes enzymes into reaction vessels and templates for the formation of their own inhibitors.

近期论文

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Taylor, P., Yan-Jye, S., Momper, J., Hou, W., Camacho-Hernandez, G. A., Radic, Z., Rosenberg, Y., Kovarik, Z., Sit, R., Sharpless, K. B. Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure Chemico-Biological Interactions 2019 308:194-197 DOI:10.1016/j.cbi.2019.05.015 PMID:31100277 Hong, S., Shi, Y., Wu, N. C., Grande, G., Douthit, L., Wang, H., Zhou, W., Sharpless, K. B., Wilson, I. A., Xie, J., Wu, P. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification Nature Communications 2019 10 DOI:10.1038/s41467-019-09608-w PMID:30996301 PMCID:PMC6470217 Smedley, C. J., Zheng, Q., Gao, B., Li, S., Molino, A., Duivenvoorden, H. M., Parker, B. S., Wilson, D. J. D., Sharpless, K. B., Moses, J. E. Bifluoride ion mediated SuFEx trifluoromethylation of sulfonyl fluorides and iminosulfur oxydifluorides Angewandte Chemie-International Edition 2019 58:4552-4556 DOI:10.1002/anie.201813761 PMID:30740848 Liu, F., Wang, H., Li, S., Bare, G. A. L., Chen, X., Wang, C., Moses, J. E., Wu, P., Sharpless, K. B. Biocompatible SuFEx click chemistry: thionyl tetrafluoride (SOF4)-derived connective hubs for bioconjugation to DNA and proteins Angewandte Chemie-International Edition 2019 58:8029-8033 DOI:10.1002/anie.201902489 PMID:30998840 PMCID:PMC6546515 Kovarik, Z., Hrvat, N. M., Kalisiak, J., Katalinic, M., Sit, R. K., Zorbaz, T., Radic, Z., Fokin, V. V., Sharpless, K. B., Taylor, P. Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase Toxicology and Applied Pharmacology 2019 372:40-46 DOI:10.1016/j.taap.2019.04.007 PMID:30978400 Gastaminza, P., Chisari, F. V., Pitram, S. M., Sharpless, K. B., Fokin, V. V., Krasnova, L. B., Dong, J., inventors; USA, assignee. Inhibitors of hepatitis C virus infection World patent WO2011091152A1 (2011). Gastaminza, P., Chisari, F. V., Pitram, S. M., Fokin, V. V., Sharpless, K. B., Krasnova, L. B., Dong, J., inventors; Scripps Research, assignee. Preparation and compositions of piperazine compounds as inhibitors of hepatitis C virus infection World patent WO2010014744A1 (2010). Sharpless, K. B. Studies of the mechanism of action of 2,3-oxidosqualenelanosterol cyclase featuring enzymic cyclization of modified squalene oxides 1968