个人简介
EDUCATION
Illinois Institute of Technology, Chicago, Illinois 60616, 1959 to 1963.
B.S., Chemistry, 1963; spent 1½ years working for Dr. A. E. Martell, Chairman, Chemistry Department, on the chelative structure of reduced glutathione.
The Johns Hopkins University Medical School, Baltimore, Maryland 21205, 1963 to 1967.
1963-1966, Ph.D., Physiological Chemistry; during the first year of graduate school, participated in a research project, "The Effects of Sr++ on Swelling and ATP-Linked Contraction of Mitochondria," under the supervision of Dr. Albert L. Lehninger. Thesis work, under the supervision of Dr. J. W. Greenawalt, was concerned with the separation, identification and characterization of the inner and outer mitochondrial membranes. This entailed a combined electron microscopic and biochemical approach.
1966-1967, Postdoctoral Fellow with Dr. C. R. Hackenbrock, Department of Anatomy; research was concerned with an investigation of the ultrastructure of isolated, intact mitochondria during various metabolic states. The observations obtained were used to elaborate the general thesis of the ultrastructural basis for energy transfer.
Brandeis University, Waltham, Massachusetts 02154, 1967 to 1969.
1967-1968, Postdoctoral Fellow with Dr. N. O. Kaplan, Graduate Department of Biochemistry; in collaboration with Dr. E. Zwilling of the Biology Department, investigation of the effects of nicotinamide-antagonized teratogens on cartilage and muscle development in both in vitro and in vivo systems.
1968-1969, Postdoctoral Fellow with Dr. E. Zwilling, Department of Biology; continuation of work initiated during the previous year.
WORK HISTORY
Case Western Reserve University, Cleveland, Ohio 44106, 1969 to Present.
1981-Present Professor, Department of Biology.Director, Cellular and Molecular Basis of Aging Training Program (ended 2007).
1986-Present Director, Skeletal Research Center.Professor of General Medical Sciences (Oncology).
2005- Present Professor of Biomedical Engineering.
2004-2011 Professor of Pathology.
1989-2000 Professor of Physiology and Biophysics.
1984-1985 Erna and Jakob Michael Visiting Professor, Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.
1981-1988 Professor, Developmental Genetics and Anatomy.
1976-1977 (Josiah Macy, Jr. Faculty Scholar Award), Sabbatical Leave, Faculte de Medecine de Strasbourg, Institute de Chimie Biologique, 67085 Strasbourg CEDEX, France. In the laboratory of Prof. Pierre Chambon, research involved investigation of chromatin structure and function, especially as related to molecular details of the relationship between poly (ADP-ribose) and other chromatin constituents.
1975-1981 Associate Professor, Departments of Biology and Anatomy; Co-Director, Developmental Biology Center; Research involved elucidation of the factors controlling muscle, bone and cartilage development in chick limb mesodermal cells. A working hypothesis was sug¬gested that the local metabolic environment had a profound effect on the choice mechanism(s) governing mesodermal cell differentiation into particular phenotypic pathways.
1975-1991 Co-Director, Cellular and Molecular Biology Training Program.
1973 (Research Career Development Award) Leave of Absence as Visiting Professor, Department of Biochemistry and Biophysics, University of California Medical School, San Francisco, California 94122. In collaboration with Dr. Brian J. McCarthy, investigation into the basis of gene selectivity.
1969-1975 Assistant Professor, Departments of Biology and Anatomy (Medical School).
HONORS/AWARDS
1. Lifetime Achievement Award, National Center for Regenerative Medicine, August 2015
2. Inaugural Member of the “Pioneers of Innovation” chosen by the Advocacy Committee of the Orthopaedic Research Society, March 2014
3. Honorary Alumni of the Year Award, School of Med., Case Western Reserve University, September 2013
4. TERMIS-NA 2010 Inaugural Lifetime Achievement Award, December 2010
5. Elected Fellow: College of Fellows of the American Institute for Medical and Biological Engineering, Instillation, February 2010.
6. Honorary Member: Stem Cell Research Italy, 2010
7. The Genzyme Life-Time Achievement Award given by the International Cartilage Repair Society, October, 2007
8. The Marshall Urist Award for Excellence in Tissue Regeneration Research presented by the Orthopaedic Research Society, February 1999.
9. The Elizabeth Winston Lanier Award given by the American Academy of Orthopaedic Surgeons as part of their 1990 Kappa Delta Awards conferred on February 8, 1990.
10. The Erna and Jakob Michael Visiting Professorship; The Weizmann Institute of Science, Israel, 1984-85.
11. Josiah Macy Faculty Scholar Award, 1976-1977.
12. National Institutes of Health Career Development Award, 1971-1976.
13. American Cancer Society Postdoctoral Fellowship, 1967-1969.
研究领域
The emphasis of our studies is to develop and refine the technology necessary to isolate one of these rare stem cells, the mesenchymal stem cell (MSC). The MSC gives rise to bone-forming cells, cartilage-forming cells and cells of tendon, ligament fat, and dermis, as well as various connective tissues including the stroma of marrow. Following isolation and by mitotically expanding their numbers in culture, we can drive these cells down specific and different developmental pathways with emphasis on cartilage and bone. The experimental approaches use the classical information of both morphogenesis and organogenesis coupled with the new information of the control of developmental lineage progression as controlled by potent growth factors. The knowledge gained from animal models will be directly applied to the study of human MSC, as our preliminary studies have already proven to be successful. These studies integrate both basic scientists and clinicians to more effectively translate these basic science findings into new, innovative human health care protocols of using tissue engineering to repair skeletal tissues as in this accompanying.
近期论文
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Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor.Dai Y, Somoza RA, Wang L, Welter JF, Li Y, Caplan AI, Liu CC.Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print] Review.
Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage.Vail DJ, Somoza RA, Caplan AI, Khalil AM.J Tissue Eng Regen Med. 2019 Sep 10. doi: 10.1002/term.2961. [Epub ahead of print]
International Expert Consensus on a Cell Therapy Communication Tool: DOSES.Murray IR, Chahla J, Safran MR, Krych AJ, Saris DBF, Caplan AI, LaPrade RF; Cell Therapies Communication Expert Group.J Bone Joint Surg Am. 2019 May 15;101(10):904-911. doi: 10.2106/JBJS.18.00915.
There Is No "Stem Cell Mess".Caplan AI.Tissue Eng Part B Rev. 2019 Aug;25(4):291-293. doi: 10.1089/ten.TEB.2019.0049.
Tissue Engineering: Then, Now, and the Future.Caplan AI.Tissue Eng Part A. 2019 Apr;25(7-8):515-517. doi: 10.1089/ten.TEA.2019.0011. Epub 2019 Mar 28.
Author Accountability in Biomedical Research.Caplan A, Badylak SF, Caplan AI, Davies LC, Strömblad S, Weiss DJ, Le Blanc K.Stem Cells Dev. 2018 Nov 20. doi: 10.1089/scd.2018.0214. [Epub ahead of print] No abstract available.
Cell-Based Therapies: The Nonresponder.Caplan AI.Stem Cells Transl Med. 2018 Nov;7(11):762-766. doi: 10.1002/sctm.18-0074. Epub 2018 Sep 25.
Rapid Detection of Shear-Induced Damage in Tissue-Engineered Cartilage Using Ultrasound.Mansour JM, Motavalli M, Dennis JE, Kean TJ, Caplan AI, Berilla JA, Welter JF.Tissue Eng Part C Methods. 2018 Aug;24(8):443-456. doi: 10.1089/ten.TEC.2017.0513.
Dynamics of Intrinsic Glucose Uptake Kinetics in Human Mesenchymal Stem Cells During Chondrogenesis.Zhong Y, Motavalli M, Wang KC, Caplan AI, Welter JF, Baskaran H.Ann Biomed Eng. 2018 Nov;46(11):1896-1910. doi: 10.1007/s10439-018-2067-x. Epub 2018 Jun 14.
Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor.Lennon D, Solchaga LA, Somoza RA, Schluchter MD, Margevicius S, Caplan AI.Tissue Eng Part A. 2018 Dec;24(23-24):1831-1843. doi: 10.1089/ten.TEA.2018.0126. Epub 2018 Aug 22.
Injectable liquid polymers extend the delivery of corticosteroids for the treatment of osteoarthritis.Rivera-Delgado E, Djuhadi A, Danda C, Kenyon J, Maia J, Caplan AI, von Recum HA.J Control Release. 2018 Aug 28;284:112-121. doi: 10.1016/j.jconrel.2018.05.037. Epub 2018 Jun 12.
Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation.Kenyon JD, Sergeeva O, Somoza RA, Li M, Caplan AI, Khalil AM, Lee Z.Tissue Eng Part A. 2019 Jan;25(1-2):80-90. doi: 10.1089/ten.TEA.2017.0440. Epub 2018 May 24.
ROCK Inhibition Promotes the Development of Chondrogenic Tissue by Improved Mass Transport.Wang KC, Egelhoff TT, Caplan AI, Welter JF, Baskaran H.Tissue Eng Part A. 2018 Aug;24(15-16):1218-1227. doi: 10.1089/ten.TEA.2017.0438. Epub 2018 Apr 23.
Mesenchymal Stem Cell Soluble Mediators and Cystic Fibrosis.Sutton MT, Fletcher D, Episalla N, Auster L, Kaur S, Gwin MC, Folz M, Velasquez D, Roy V, van Heeckeren R, Lennon DP, Caplan AI, Bonfield TL.J Stem Cell Res Ther. 2017 Aug;7(9). pii: 400. doi: 10.4172/2157-7633.1000400. Epub 2017 Sep 22.
Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production.Sorrell JM, Somoza RA, Caplan AI.J Orthop Res. 2018 Jun;36(6):1757-1766. doi: 10.1002/jor.23820. Epub 2017 Dec 22.
Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling.Goldstein BD, Lauer ME, Caplan AI, Bonfield TL.J Inflamm (Lond). 2017 Aug 30;14:18. doi: 10.1186/s12950-017-0165-4. eCollection 2017.
Nondestructive/Noninvasive Imaging Evaluation of Cellular Differentiation Progression During In Vitro Mesenchymal Stem Cell-Derived Chondrogenesis.Correa D, Somoza RA, Caplan AI.Tissue Eng Part A. 2018 Apr;24(7-8):662-671. doi: 10.1089/ten.TEA.2017.0125. Epub 2018 Jan 10.
Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage.Somoza RA, Correa D, Labat I, Sternberg H, Forrest ME, Khalil AM, West MD, Tesar P, Caplan AI.Tissue Eng Part A. 2018 Feb;24(3-4):335-350. doi: 10.1089/ten.TEA.2016.0559. Epub 2017 Jul 28.
Not Missing the Future: A Call to Action for Investigating the Role of Regenerative Medicine Therapies in Pediatric/Adolescent Sports Injuries.Best TM, Caplan A, Coleman M, Goodrich L, Hurd J, Kaplan LD, Noonan B, Schoettle P, Scott C, Stiene H, Huard J.Curr Sports Med Rep. 2017 May/Jun;16(3):202-210. doi: 10.1249/JSR.0000000000000357.
Mesenchymal Stem Cells: Time to Change the Name!Caplan AI.Stem Cells Transl Med. 2017 Jun;6(6):1445-1451. doi: 10.1002/sctm.17-0051. Epub 2017 Apr 28.
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