马鸣 - 西南大学 - 生命科学学院

个人简介

马鸣, 教授, 博士生导师。2007年获新加坡国立大学博士学位。2008-2009年在耶鲁大学医学院肾内科从事博士后研究工作，2010-2017年被聘为副研究科学家。2017年入职西南大学生命科学学院。马鸣实验室的主攻方向是“肾脏发育与肾脏遗传病研究”。其研究成果在以第一作者发表在Nature Genetics (Article), Journal of the American Society of Nephrology, Cold Spring Harbor Perspectives in Biology, PLoS Genetics等杂志上。2013年美洲华人肾脏协会就其在肾脏病研究领域的贡献授予了奖状(Chinese American Society of Nephrology Outstanding Trainee Award)。2014年获得美国多囊肾病基金会的科研基金(PKD Foundation) Research Grant-In-Aid。2017年入选第13批“青年**”。现主持国家自然科学基金面上项目。

研究领域

实验室以小鼠，大鼠和斑马鱼为模型，研究方向为： 1. 囊肿病的发病机理 2. 纤毛在器官发育和稳态维持中的功能 3. 肾脏上皮细胞分化

近期论文

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Ming Ma, Emilie Legué, Xin Tian, Stefan Somlo, Karel Jr. Liem. (2019). Cell-Autonomous Hedgehog Signaling Is Not Required for Cyst Formation in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology. 2019 Aug 26. pii: ASN.2018121274. doi: 10.1681/ASN.2018121274. Valeria Padovano, Ivana Y. Kuo, Lindsey K. Stavola, Hans R. Aerni, Benjamin J. Flaherty, Hannah C. Chapin, Ming Ma, Stefan Somlo, Alessandra Boletta, Barbara E. Ehrlich, Jesse Rinehart, and Michael J. Caplan. (2017). The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Molecular Biology of the Cell. 28(2):261-269. Ming Ma, Anna-Rachel Gallagher, Stefan Somlo. (2017). Ciliary mechanisms of cyst formation in polycystic kidney disease. Cold Spring Harbor Perspectives in Biology. 9(11). pii: a028209. doi: 10.1101/cshperspect.a028209.(封面) Yuanyuan Li, Xin Tian, Ming Ma, Shanshan Kong, Stefan Somlo, Zhaoxia Sun (2016). Deletion of the Joubert syndrome gene Arl13b leads to cystic kidney in mouse. Journal of the American Society of Nephrology. 27(12): 3628-3638. Ming Ma, Xin Tian, Peter Igarashi, Gregory J. Pazour, and Stefan Somlo (2013). Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nature Genetics. (Article) 45 (9) 1004-1012. Ellen F. Carney “Polycystic kidney disease: Cyst growth and cilia in ADPKD” in Nature Review Nephrology. 9, 555 (2013). 突出推荐 Ong A and Streets A: F1000 Prime Recommendation of [Ma M et al., Nat Genet 2013]. In F1000Prime, 30 Sep 2013. 推荐 Patankar JV. Novel cilia-dependent pathway activates rapid cyst growth in autosomal dominant polycystic kidney disease. Clinical Genet. 2014 Mar; 85 (3):230-2. 热点推荐 Hong Ma, Akashi Togawa, Keita Soda, Junhui Zhang, Sik Lee, Ming Ma, Zhiheng Yu, Thomas Ardito, Jan Czyzyk, Lonnette Diggs, Dominique Joly, Shinji Hatakeyama, Eiji Kawahara, Lawrence Holzman, Jun Lin Guan and Shuta Ishibe (2010). Inhibition of podocyte FAK protects against proteinuria and foot process effacement. Journal of the American Society of Nephrology. 21 (7) 1145-1156. Chung-Der Hsiao, May-Su You, Ying-Jey Guh, Ming Ma, Yun-Jin Jiang, Pung-Pung Hwang (2007). A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytes. PLoS ONE 2:e302. Ming Ma and Yun-Jin Jiang (2007). Jagged2a-Notch signaling mediates cell fate choice in zebrafish pronephric duct. PLoS Genetics. 3(1) e18. Ming Ma, Teck Koon Tan and Sek Man Wong (2003). Identification and molecular phylogeny of Epulorhiza isolates from tropical orchids. Mycological Research. 107: 1041-1049.