个人简介

Alfred Bader Award in Bioinorganic or Bioorganic Chemistry, American Chemical Society 2014 Guggenheim Fellowship 2008 Member, Wisconsin Academy of Sciences, Arts and Letters 2007 Member, National Academy of Sciences 2007 Member, American Academy of Microbiology 2007

研究领域

Chemical Biology/Materials/Organic

All cells on Earth possess a carbohydrate coat. Emerging evidence indicates that this coat serves as a critical conduit of information, but little is known at the molecular level. Elucidating how carbohydrates are assembled, how they are recognized, and how they function are issues at the scientific frontier. Using ideas and approaches that range from synthetic chemistry to cell biology, our research group is addressing the critical issues at this frontier. Follow the links below to learn about the key elements of our research program and see relevant references: Chemistry to Explore and Exploit Multivalent Protein-Carbohydrate Interactions Multivalent Carbohydrates as New and Powerful Probes of Signal Transduction Carbohydrate Polymer Biosynthesis: A New Target for Anti-Tuberculosis Agents Carbohydrate Polymer Biosynthesis: Controlling Length Carbohydrate Polymers and Human Embryonic Stem Cell Pluripotency

近期论文

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Musah S, Wrighton PJ, Zaltsman Y, Zhong X, Zorn S, Parlato, MB, Hsiao C, Palecek SP, Chang Q, Murphy WL, Kiessling LL. Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proc Nat Acad Sci USA. Epub 2014 Sept 8. Sheridan RT, Hudon J, Hank JA, Sondel PM, Kiessling LL. Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells. Chembiochem. 2014 Jul 7;15(10):1393-8. Martinez Farias MA, Kincaid VA, Annamalai VR, Kiessling LL. Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates. J Am Chem Soc. 2014 Jun 18;136(24):8492-5. Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ. New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. 2014 Mar 18;53(10):1575-85. Courtney AH, Bennett NR, Zwick DB, Hudon J, Kiessling LL. Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling. ACS Chem Biol. 2014 Jan 17;9(1):202-10. Kiessling LL, Kraft MB. Chemistry. A path to complex carbohydrates. Science. 2013 Jul 26;341(6144):357-8. Wesener DA, May JF, Huffman EM, Kiessling LL. UDP-Galactopyranose Mutase in Nematodes; Biochemistry. 2013 Jun 25;52(25):4391-8. Kiessling LL, Grim JC. Glycopolymer probes of signal transduction. Chem Soc Rev. 2013 May 21;42(10):4476-91. Fishman JM, Kiessling LL. Synthesis of functionalizable and degradable polymers by ring-opening metathesis polymerization.;Angew Chem Int Ed Engl. 2013 May 3;52(19):5061-4. Kraft MB, Martinez Farias MA, Kiessling LL. Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases.J Org Chem. 2013 Mar 1;78(5):2128-33. Musah S, Morin SA, Wrighton PJ, Zwick DB, Jin S, Kiessling LL. Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. ACS Nano. 2012 Nov 27;6(11):10168-77. Kiessling LL. Recasting Biomolecules for Function. ACS Chem Biol. 2012 Jan 20;7(1):1-2. Prost LR, Grim JS, Tonelli M, Kiessling LL. Non-Carbohydrate Glycomimetics and Glycoprotein Surrogates as DC-SIGN Antagonists and Agonists. ACS Chem Biol. 2012 Jul 19 Brown CD, Rusek MS, Kiessling LL. Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase. J Am Chem Soc. 2012 Apr 18;134(15):6552-5. Epub 2012 Apr 10. Mangold SL, Prost LR, Kiessling LL. Quinoxalinone Inhibitors of the Lectin DC-SIGN. Chem Sci. 2012 Mar;3(3):772-777. Epub 2011 Nov. 24. Wong ML, Guzei IA, Kiessling LL. An Asymmetric Synthesis of l-Pyrrolysine. . 2012 Mar 16;14(6):1378-81. Epub 2012 Mar 6. May JF, Levengood MR, Splain RA, Brown CD, Kiessling LL. A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site. Biochemistry. 2012 Feb 14;51(6):1148-59. Epub 2012 Feb 3. Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RT, Wong ML, Kiessling LL. Small-Molecule-Modified Surfaces Engage Cells through the α(v)β(3) Integrin. ACS Chem Biol. 2012 Mar 16;7(3):518-25. Epub 2012 Jan 26. Levengood MR, Splain RA, Kiessling LL. Monitoring Processivity and Length Control of a Carbohydrate Polymerase. J Am Chem Soc. 2011 Jul 25 Epub. Li L, Klim JR, Derda R, Courtney AH, Kiessling LL (2011) Spatial control of cell fate using synthetic surfaces to potentiate TGF-B signaling. Proc Natl Acad Sci USA. 108(29):11745-50. Epub 2011 Jun 30