王志钢 - 内蒙古大学 - 省部共建草原家畜生殖调控与繁育国家重点实验室

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学习和工作经历 1980-1984 ，内蒙古大学生物系动物专业本科 1997-2001 ，内蒙古大学生命科学学院动物专业同等学力硕士研究生 2004-2008 ，内蒙古大学生命科学学院动物专业博士研究生 1984-2001 ，内蒙古赤峰市卫生防疫站主任医师 2001- 现在，内蒙古大学生命科学学院教授博士生导师近年主持课题 1 ） mTOR 信号通路在牛乳腺上皮细胞乳脂合成中的作用与机制（ 31360561 ），国家自然科学基金委员会， 2014-2017 ， 51 万元。 2 ）绒山羊成纤维细胞内 mTORC1 调控氨基酸代谢的分子机制（ 31160469 ），国家自然科学基金委员会， 2012-2015 ， 54 万元。 3 ） mTOR 信号通路在绒山羊胎儿成纤维细胞生长调控中的作用与机制（ 30860191 ），国家自然科学基金委员会， 2009-2011 ， 25 万元。 4 ）高产绒量绒山羊新品系培育转基因重大专项子课题（ 2008ZX08008-002 ； 2011ZX08008-002 ； 2013ZX08008-002 ； 2014ZX08008-002 ），科技部，共 191.7 万元。 5) mTORC1 在鞭毛蛋白诱导的炎症细胞因子表达中的调控作用与机制（ 2015MS0327 ），内蒙古自然基金委员会， 3 万元。 6 ）绒山羊胎儿成纤维细胞中 FAK 与 TSC2 相互作用的蛋白质组学研究（ 2011MS0521 ），内蒙古自然基金委员会， 3 万元。专利 1) 绒山羊 S6K1 基因 cDNA 编码区核苷酸序列（ 2010 已授权）专利号 ZL 2007 1 0084517.3 2) 一种同时分离内蒙古白绒山羊皮肤成纤维细胞和表皮细胞的原代培养方法（ 2014 授权）专利号 ZL 2012 1 0564250.9

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1 ） Bao W, Wang Y, Fu Y, Jia X, Li J, Vangan N, Bao L, Hao H, Wang Z*. mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. PLoS One, 2015, 10(5):e0125910. doi:10.1371/journal.pone.0125910. eCollection 2015. 2 ） Weipeng Wang, Qiburi He, Zhixin Guo, Limin Yang, Lili Bao, Wenlei Bao, Xu Zheng, Yanfeng Wang and Zhigang Wang* Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts. Int. J. Mol. Sci. 2015 , 16, 16440-16453; doi:10.3390/ijms160716440 3 ） Y.T. Fu, X. Zheng, Q. He, X.Y. Jia, Z.X. Guo, R.Y. Yao, Y.F. Wang and Z.G. Wang*. Silencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts. Genet. Mol. Res., 2015, 14(3): 9675-9682 4 ） W.L. Bao, R.Y. Yao, Q. He, Z.X. Guo, C. Bao, Y.F. Wang, Z.G. Wang*. Cloning, molecular characterization, and expression pattern of FGF5 in Cashmere goat ( Capra hircus ) goat (Capra hircus). Genet. Mol. Res. 2015, 14 (3): 11154 – 11161. 5) Xu Zheng, Yan Liang, Qiburi He, Ruiyuan Yao, Wenlei Bao, Lili Bao, Yanfeng Wang and Zhigang Wang*. Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids. Int. J. Mol. Sci. 2014, 15: 20753-20769. 6) K.L. Ma, V. Nyamtsengel, W.L. Bao, M.Y. Lian, W.P. Wang, Y.F. Wang, X. Wang and Z.G. Wang ﹡ . Overexpression of protein kinase B/AKT induces phosphorylation of p70S6K and 4E-BP1 in goat fetal fibroblasts. Genetics and Molecular Research, 2014 ， 13(4): 9931-9938. 7) X. J. Wang, H. M. Su, Y. Liang, Y.F. Wang, X.D. Guo, ﹡ Z.G. Wang , D.J Liu. Stable transfection and identification of hair follicle-specific expression vector of IGFBP-5 in goat fetal fibroblasts. Genetics and Molecular Research, 2014 ， 13(1): 1885-1892. 8) Xiaojing Wang, Yanfeng Wang, Xu Zheng, Xiyan Hao, Yan Liang, Manlin Wu, Xiao Wang, and Zhigang Wang* . Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells. Asian-Aust. J. Anim. Sci., 2014, 27(12):1671-1677. 9) Bao Wenlei, Yin Jianxin, Liang Yan, Guo Zhixin, Wang Yanfeng, Liu Dongjun, Wang Xiao, * Wang Zhigang. Recombinant goat VEGF164 increases hair growth by painting process on the skin of shaved mouse. Asian-Aust. J. Anim. Sci., 2014 ， 27 （ 9 ）： 1355-1359. 10) Wu Manlin, Bao Wenlei, Hao Xiyan, Zheng Xu, Wang Yanfeng, ﹡ Wang Zhigang . Molecular characterization and expression analysis of S6K1 in Cashmere Goat (Capra hircus). Asian-Aust. J. Anim. Sci., 2013, 26 （ 8 ） : 1057-1064. 11)Shuyu Li, Yan Liang, Manlin Wu, Xiaojing Wang, Haixia Fu , Yuhao Chen, ﹡ Zhigang Wang . The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells. Cancer Cell Int. 2013, 13 (1):30. doi:10.1186/1475-2867-13-30. 12) Bao Wenlei, Hao Xiyan, Zheng Xu, Liang Yan, Chen Yuhao, Wang Yanfeng, and ﹡ Wang Zhigang Molecular Characterization and Expression Analysis of Ribosomal Protein S6 Gene in the Cashmere Goat ( Capra hircus ) . Asian-Aust. J. Anim. Sci., 2013, 26(11): 1644-1650. 13) ﹡ Zhigang WANG , Taodi LIU, Yuhao CHEN , Xin ZHANG, Mingtao LIU, Haixia FU, Dongjun LIU Inhibition of Mammalian Target of Rapamycin Signaling by CCI-779 (Temsirolimus) Induces Growth Inhibition and Cell Cycle Arrest in Cashmere Goat Fetal Fibroblasts (Capra hircus). DNA and Cell Biology ， 2012, 31(6): 1095-1099. 14) Yan Liang, Wen-Lei Bao, Chebri, Chan-Chan Bao, Xiu-Fen Miao, Hui-Fang Hao, Shu-Yu Li, ﹡ Zhi-Gang Wang , Dong-Jun Liu Molecular characterization and functional analysis of Cashmere goat mammalian target of rapamycin. DNA and Cell Biology ， 2012, 31(5): 839-844. 15) X. J. Wang, J. J. Shi, J. F. Yang, Y. Liang, Y. F. Wang, M. L. Wu, S. Y. Li, X. D. Guo, ﹡ Z. G. Wang , and D. J. Liu. Molecular Characterization and Expression Pattern of Gene IGFBP-5 in the Cashmere Goat (Capra hircus). Asian-Aust. J. Anim. Sci. 2012, 25(5): 606 – 612. 16) X. Zheng, X. Y. Hao, Y. H. Chen, X. Zhang, J. F. Yang, ﹡ Z. G. Wang and D. J. Liu Molecular Characterization and Tissue-specific Expression of a Novel FKBP38 Gene in the Cashmere Goat (Capra hircus). Asian-Aust. J. Anim. Sci. 2012, 25(6):758–763. 17) LIANG Yan, LI Shu-yu, WANG Xiao-jing, WU Man-lin, YANG Jiao-fu, LI Jie, HAO Xi-yan, HAO Hui - fang , BA Y in - ma , CHEN Xian - wei , ﹡ WANG Zhi - gang . Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody. Journal of Integrative Agriculture 2012, 11(6):1002-1008. 18) Zhengxu, Yangjiaofu, Wangxiaojing, Liangyan, Wumianlin, Shijiejun, Zhangtao, Qinyi, Lishuyu, Haoyiyan, ﹡ Wangzhigang , Liudongjun. Molecular characterization and expresiion pattern of Rheb gene in Inner Mogolia Cashmere goat (Capra hircus). Agricultural Sciences in China, 2011, 10(9): 1452-1458. 19) Wang ZG, Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Hatakeyama S, Omori O, Ohara T, Tanabe S, Fujiwara Y, Takaoka M, Shirakawa Y,Yamatsuji T, Tanaka N, Naomoto Y. RAD001 (everolimus) offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer ONCOLOGY REPORTS 2010 ， 23:1167-1172. 20) Wang ZG Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T, Tanabe S, Fujiwara Y, Shirakawa Y,Yamatsuji T, Tanaka N, Naomoto Y. TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. ONCOLOGY REPORTS 2008, 20: 1473-1477. 21) Hui-fang Hao, Munenori Takaoka, Xiao-hong Bao, Zhi-gang Wang, Yasuko Tomono, Kazufumi Sakurama, Toshiaki Ohara, Takuya Fukazawa, Tomoki Yamatsuji, Toshiyoshi Fujiwara,Yoshio Naomoto. Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer. Biochemical and Biophysical Research Communications, 2012, 423: 744–749. 22) Bao, Xiao-Hong, Takaoka, Munenori, Hao, Hui-Fang, Wang, Zhi-Gang, Fukazawa, Takuya, Yamatsuji, Tomoki, Sakurama, Kazufumi, Sun, Dong-Sheng, Nagasaka, Takeshi, Fujiwara, Toshiyoshi, *Naomoto, Yoshio. Esophageal Cancer Exhibits Resistance to a Novel IGF-1R Inhibitor NVP-AEW541 with Maintained RAS-MAPK Activity. Anticancer Research, 2012, 32: 2827-2834. 23 ） Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Wang ZG, Takaoka M. Focal adhesion kinase as potential target for cancer therapy (Review) ONCOLOGY REPORTS 2009, 22: 973-979. 24) Zhao, X. A., Cang, M., Yuan, J. L., Wang, Z. G., Yang, M. L., Gao, X. Y., Zhu, B., Liang, H., Liu, D. J. Interleukin-6 and its receptor in the development of in vitro fertilized ovine embryos. Small Ruminant Research, 2012, 102: 43-50. 25) Zhao Xi-an, Cang Ming, Gao Xiao-yu, Yang Mei-ling, Yuan Jian-long, Zhu Bing, Wang Zhi-gang, Liu Dong-jun. Expression of Interleukin-6 and Interleukin-6 Receptor in Ovine Oocytes During In vitro Maturation. Journal Of Integrative Agriculture, 2012, 11: 1333-1339. 26) Nishikawa T, Takaoka M, Ohara T, Tomono Y, Hao H, Bao X, Fukazawa T, Wang Z, Sakurama K, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y. Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice. Cancer Biol Ther. 2013 14(3):230-236. 27) Yuan, Jianglong; Jin, Yong; Zhu, Bing; Wang, Wei; Ren, Yu; Wu, Haiqing; Hao, Fei; Nuo, Mingtu; Jin, Muzi; Wang, Zhigang; Chang, Ming; Liu, Dongjun; Guo, Xudong. Somatic Cell Nuclear Transfer Efficiency Associated with Donor Cell Types in the Cashmere goat. JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2012, 24(11):4578-4584.

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