个人简介
莫日根（Morigen），2005年毕业于挪威奥斯陆大学医学院分子生物学专业，获博士学位。之后在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师。
研究领域
1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.
2. DNA replication in cancer cells.
1. 细菌DNA复制、细胞周期及环境适应分子机制与耐药性。主要以大肠杆菌为模式生物，研究DNA复制与基因组稳定、细胞周期、代谢和基因表达调控分子机制，揭示细胞环境适应性和耐药性分子机理。
2. 癌细胞DNA复制与基因组稳定性。研究癌细胞DNA复制与基因组稳定性以及肿瘤发生发展和早期诊断。
近期论文
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1. Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.
2. Yao Y, Fan L, Shi Y, Odsbu I, Morigen*A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes,8(1), 1, doi:10.3390/genes8010001, 2017.
3. Wurihan, Wunier, Li H, Fan L, Morigen* Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli,
Gent Mol Res, 15 (3): gmr.15 038407, 2016.
4. Yao Y, Wunier, Morigen*Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli, Gent Mol Res, 14(4):16888-16895, 2015.
5. Fan L, Yan H, Pellegrin S, Morigen*, H Mellor The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett,590(-):178-183, 2015.
6. Dong Q, Dong A, Morigen*Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli
induced by DksA protein, Molecules, 21; 20(4):7292-308, 2015.
7. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.
8. Morigen, Flatten I, K Skarstad The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.
9. Fan L, Morigen*Rho and Ras GTPases in semaphorin-mediated neuronal development, Adv Biosci Biotech, 4:136-142, 2013.
10. Johnsen L, Flatten I, Morigen, Dalhus B, Bjoras M, Waldminghaus T, K Skarstad The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication, Mol Microbiol , 79(2):433-446, 2011.
11.Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Y Shi The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.
12. Morigen, Odsbu I, K Skarstad Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli, Genes Cells, 14(5):643-657, 2009.
13. Wang J, Morigen BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.
14. Odsbu I., Morigen, K Skarstad A reduction in ribonucleotide reductase activity slows down the chromo some replication fork but does not change its localization, PLoS ONE, 4(10):e7617, 2009.
15. Flatten I, Morigen, K Skarstad DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol,71(4):1018-1030, 2009.
16. Bach T, Morigen, K Skarstad The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA, J Mol Biol, 384(5):1076-85, 2008.
17. Morigen, Molina F, K Skarstad Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication,J Bacteriol, 187(12):3913-20, 2005.
18. Morigen, Lobner-Olesen A, K Skarstad Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks,delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.
19. Morigen, Boye E, Skarstad K, A Lobner-Olesen Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region, Biochim Biophys Acta, 1521: 73-80, 2001.
20. Weigel C, Messer W, Preiss S, Welzeck M, Morigen, E Boye The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.
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