冯云鹏 - 东北师范大学 - 生命科学学院

个人简介

丹麦哥本哈根大学 (University of Copenhagen) 博士，丹麦生物技术与创新研究中心 (Biotech Research & Innovation Centre, BRIC) 博士后。2016年1月，入选东北师范大学引进人才计划回国工作。 2016-至今副教授，东北师范大学。 2013-2015 博士后，哥本哈根大学，丹麦。 2009-2014 博士，哥本哈根大学，丹麦。 2008-2009 研究助理，哥本哈根大学，丹麦。 2005-2008 硕士，遗传与细胞研究所，东北师范大学，中国。 2001-2005 学士，生命科学学院，东北师范大学，中国。获奖情况: 2013 国家优秀留学博士奖学金，中国。 2011 最佳海报奖（第一名），国际会议 Frontiers in Cell Biology - 39th Annual Meeting，赫尔辛格，丹麦。

研究领域

多年来致力于研究表观遗传调控在细胞代谢及基因组稳定性维护中的作用，鉴定了多个调控DNA复制和损伤的染色质调节因子。发现染色质结合因子BRPF3、组蛋白供应以及泛素连接酶TRAIP在DNA复制和损伤应答过程中发挥至关重要的作用。此外，揭示了转录因子ZBP-89和YY1通过控制组蛋白去乙酰化酶HDACs在关键基因启动子处的招募和结合，调节了目的基因的转录和表达，并最终影响细胞的衰老或凋亡。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Chen L, Jiao Y, Guan X, Li X, Feng Y, Jiao M. (2018) Investigation of cell cycle-associated structural reorganization in nucleolar FC/DFCs from mouse MFC cells by electron microscopy. Microscopy 2. Hao F, Tian M, Feng Y, Quan C, Chen Y, Chen S, Wei M. (2018) Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice. J Immunol. 3. Jin X, Bu Q, Zou Y, Feng Y, Wei M. (2018) Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconj J. 4. Wang Y, Liu J, Jin X, Zhang D, Li D, Hao F, Feng Y, Gu S, Meng F, Tian M, Zheng Y, Xin L, Zhang X, Han X, Aravind L, Wei M. (2017) O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. PNAS 5. Guan X, Jiao Y, Chen L, Li X, Shang G, Wang F, Feng Y, Jiao M. (2017) Disruption and restoration of nucleolar FC and DFC during S phase in HeLa cells. Cell Biol Int. 6. Feng Y*, Vlassis A*, Lalonde ME*, Lees M, Zhao X, Alabert C, Johansen JV, Sandelin A, Côté J, Groth A. (2016) BRPF3-HBO1 complex regulates replication origin firing and histone H3K14 acetylation. EMBO J 7. Hoffmann S, Smedegaard S, Nakamura K, Räschle M, Oka Y, Feng Y, Mann M, Groth A, Bekker-Jensen S, Mailand N. (2016) TRAIP is a PCNA-associated ubiquitin ligase that protects genome stability after replication stress. J Cell Biol 8. Mejlvang J*, Feng Y*, Alabert C, Neelsen K. J, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A. (2014) New Histone Supply Regulates Replication Fork Speed and PCNA Unloading. (* Equal contribution). J Cell Biol 9. Feng Y*, Wang X*, Xu L, Pan H, Zhu S, Liang Q, Huang B, Lu J. (2009) The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. (* Equal contribution). FEBS J 10. Wang X*, Feng Y*, Xu L, Chen Y, Zhang Y, Su D, Ren G, Lu J, Huang B. (2008) YY1 restrained cell senescence through repressing the transcription of p16. (* Equal contribution). BBA-MOL CELL RES 11. Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. (2012) Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J 12. Wang X, Feng Y, Zhao J, Pan H, Huang B, Lu J. (2010) The Expression of p16 is Regulated by The Reversible Histone Acetylation. Progress in Biochemistry and Biophysics 13. Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, Pan L, Zhang Y, Lu J, Huang B. (2009) BMP4-Smad signal pathway mediates Adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 14. Ren G, Zhang G, Dong Z, Liu Z, Li L, Feng Y, Su D, Zhang Y, Huang B, Lu J. (2009) Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. Int J Biochem Cell Biol 15. Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J. (2009) SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett 16. Wang X*, Pan L*, Feng Y, Wang Y, Han Q, Han L, Han S, Guo J, Huang B, Lu J. (2008) p300 plays a role in p16 (INK4a) expression and cell cycle arrest. Oncogene 17. Wang X, Feng Y, Pan L, Wang Y, Xu X, Lu J, Huang B. (2007) The proximal GC-rich region of p16 (INK4a) gene promoter plays a role in its transcriptional regulation. Mol Cell Biochem