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个人简介

1999-2003 河北大学 生物技术专业 学士学位 2004-2007 南开大学 生物物理专业 硕士学位 2007-2011 德国图宾根大学 生物学专业 博士学位 2011-2013 德国马克斯普朗克 遗传与发育研究所 博士后 2014-2023 东北师范大学 生物化学与分子生物学专业 副教授 2023-至今 东北师范大学 生物化学与分子生物学专业 教授

研究领域

1) 酶的催化机制和结构 2) 凝集素的功能与结构 3) 细胞信号转导 4) 蛋白质与糖的相互作用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma,ACTA BIOCH BIOPH SIN,2023年 Structural basis for glucosylsucrose synthesis by a member of the alpha-1,2-glucosyltransferase family,ACTA BIOCH BIOPH SIN,2022年 Actin binding to galectin-13/placental protein-13 occurs independently of the galectin canonical ligand-binding site,GLYCOBIOLOGY,2021年 蔗糖磷酸合酶功能、结构与催化机制的研究进展,生物工程学报,2021年 Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3,GLYCOBIOLOGY,2021年 Structure-function studies of galectin-14, an important effector molecule in embryology,FEBS J,2021年 Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity,BBA-GEN SUBJECTS,2021年 Co-crystal structure of Thermosynechococcus elongatus sucrose phosphate synthase with UDP and sucrose-6-phosphate provides insight into the mechanism of action involving an oxocarbenium ion and the glycosidic bond,FRONTIERS IN MICROBIOLOGY,2020年 Galectin-13/placental Protein 13: Redox-Active Disulfides as Switches for Regulating Structure, Function and Cellular Distribution,GLYCOBIOLOGY,2020年 生物化学综合实验课程改革探索,实验室研究与探索,2019年 Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate,INT J MOL SCI,2019年 Identification of key amino acid residues determining ligand binding specificity, homodimerization and cellular distribution of human galectin-10,GLYCOBIOLOGY,2019年 Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose,BIOSCIENCE REP,2018年 A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research,MOLECULES,2018年 Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding,GLYCOBIOLOGY,2018年 Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138,SCIENTIFIC REPORTS,2018年 Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function,BIOCHEM J,2017年 Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker,INT J MOL SCI,2016年 Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination,ACTA BIOCH BIOPH SIN,2016年 Structural and Biochemical Characterization of a Cyanobacterial PP2C Phosphatase Reveals Insights into Catalytic Mechanism and Substrate Recognition,CATALYSTS,2016年 限制性蛋白酶解提高 E.coli Hfq 蛋白晶体结构分辨率,中国生物化学与分子生物学报,2015年 The water network in galectin-3 ligand binding site guides inhibitor design,ACTA BIOCH BIOPH SIN,2015年

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