孙冰冰 - 大连理工大学

个人简介

孙冰冰，教授，博士生导师。2002、2005年于大连理工大学获得学士、硕士学位，2011年于美国华盛顿大学化学工程系获得博士学位，2011-2016年在美国加州大学洛杉矶分校医学院及加州大学纳米技术环境影响中心从事博士后研究工作。入选国家级青年人才、辽宁省“兴辽计划”青年拔尖人才及大连市高端人才。

研究领域

生物材料 (Biomaterials) 纳米材料-生物界面 (Nano-bio interface) 免疫工程 (Immunoengineering) 疫苗佐剂 (Vaccine adjuvant) 纳米材料生物安全性 (Nanosafety)

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yu, G.; Yang, W.; Zhang, N.; Yang, C.; Zeng, H.; Xue, C.*; Sun, B*. “Autoclave-Induced Changes in the Physicochemical Properties and Antigen Adsorption of Aluminum Adjuvants”. Journal of Pharmaceutical Sciences, Accepted. Ma, Y.; Guo, Y.; Liu, S.; Hu, Y.; Yang, C.; Cheng, G.; Xue, C.; Zuo, Y.Y.; Sun, B*. “pH-Mediated Mucus Penetration of Zwitterionic Polydopamine-Modified Silica Nanoparticles”. Nano Letters, 2023, 23(16), 7552-7560. Yan, J.; Sun, Y.; Ji, T.; Liu, Y.; Zhang, N.; Sun, B.; Meng, S.; Yin, B.; Wu, M.; Hu, H*.; Liu, Y*. “Facile Synthesis of Oriented Zr–MOF Membrane under Complete Room-Temperature Condition with Superb Selectivity for Carbon Capture”. Industrial & Engineering Chemistry Research, 2023, 62(14), 5973-5983. Guo, Y.; Ma, Y.; Chen, X.; Li, M.; Ma, X.; Cheng, G.; Xue, C.; Zuo, Y.Y.; Sun, B*. “Mucus Penetration of Surface Engineered Nanoparticles in Various pH Microenvironments”. ACS Nano, 2023, 17, 3, 2813-2828. Xu, X.; Li, G.; Sun, B.; Zuo, Y.Y*. “S2 Subunit of SARS-CoV-2 Spike Protein Induces Domain Fusion in Natural Pulmonary Surfactant Monolayers”. Journal of Physical Chemistry Letters, 2022, 13, 8359-8364. Wang, S.; Li, Y.; Ding, G.; Li, C.; Zhao, Q.; Sun, B.; Song, Q*. “Design of UVC Surface Disinfection Robot with Coverage Path Planning Using Map-Based Approach At-The-Edge” Robotics, 2022, 11(6), 117. Fu, D.; Wang, M.; Yang, T.; Li, M.; Liang, Z.; Chen, C.; Zhang, L.; Xue, C.; Sun, B*, Mao, C*. “Self-Assembled Flagella Protein Nanofibers Enhance Mucosal Immunity”. Biomaterials, 2022, 288, 121733. Cui, L.; Wang, X.; Zhao, X.; Sun, B.; Xia, T.; Hu, S*. “CeO2 nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics”. Nano Today, 2022, 45, 101559. Bi, S.; Li, M.; Liang, Z.; Li, G.; Yu, G.; Zhang, J.; Chen, C.; Yang, C.; Xue, C.; Zuo, Y.Y.; Sun, B*. “Self-Assembled Aluminum Oxyhydroxide Nanorices with Superior Suspension Stability for Vaccine Adjuvant”. Journal of Colloid and Interface Science, 2022, 627, 238-246. Chen, C.; Wang, J.; Liang, Z.; Li, M.; Fu, D.; Zhang, L.; Yang, X.; Guo, Y.; Ge, D.; Liu, Y.; Sun, B*. “Monosodium Urate Crystals with Controlled Shape and Aspect Ratio for Elucidating the Pathological Progress of Acute Gout”. Biomaterials Advances, 2022, 139, 213005. Li, M.; Liang, Z.; Chen, C.; Yu, G.; Yao, Z.; Guo, Y.; Zhang, L.; Bao, H.; Fu, D.; Yang, X.; Wang, H.; Xue, C.; Sun, B*. “Virus-Like Particle-Templated Silica-Adjuvanted Nanovaccines with Enhanced Humoral and Cellular Immunity”. ACS Nano, 2022, 16(7), 10482-10495. Li, J.; Yu, G.; Liang, Z.; Li, M.; Chen, C.; Zhang, N.; Li, X.; Guo, Y.; Yang, C.; Liu, Y.; Zhang, C.; Zhang, W.; Liu, J.; Ma, X.; Xue, C.; Sun, B*. “Mechanistic Elucidation of Freezing-Induced Surface Decomposition of Aluminum Oxyhydroxide Adjuvant”. iScience, 2022, 25 (6), 104456. Yu, G.; Liang, Z.; Yu, Z.; Li, M.; Yang, W.; Zhang, Y.; Zhao, Y.; Yang, C.; Xue, C.; Shi, L.; Sun, B*. “Engineering the Hydroxyl Content on Aluminum Oxyhydroxide Nanorod for Elucidating the Antigen Adsorption Behavior”. npj Vaccines, 2022, 7,62. Liang, Z.; Wang, X.; Yu, G.; Li, M.; Shi, S.; Bao, H.; Chen, C.; Fu, D.; Ma, W.; Xue, C.; Sun, B*. “Mechanistic Understanding of the Aspect Ratio-Dependent Adjuvanticity of Engineered Aluminum Oxyhydroxide Nanorods in Prophylactic Vaccines”. Nano Today, 2022, 43, 101445. Li, M.; Li. J.; Yang, Y.; Liu, W.; Liang, Z.; Ding, G.; Chen, X.; Song, Q.*; Xue, C.*; Sun, B*. “Investigation of Mouse Hepatitis Virus Strain A59 Inactivation Under Both Ambient and Cold Environments Reveals the Mechanisms of Infectivity Reduction Following UVC Exposure”. Journal of Environmental Chemical Engineering, 2022, 10, 107206. Zhang, L.; Liang, Z.; Chen, C.; Yang, X.; Fu, D.; Bao, H.; Li, M.; Shi, S.; Yu, G.; Zhang, Y.; Zhang, C.; Zhang, W.; Xue, C.; Sun, B*. “Engineered Hydroxyapatite Nanoadjuvants with Controlled Shape and Aspect Ratios Reveal Their Immunomodulatory Potentials”. ACS Applied Materials & Interfaces, 2021, 13(50), 59662-59672. Su, Y.; Liu, T.; Song, C.; Fan, A.; Zhu, N.; Sun, B.; Yang, C*. “Using MoS2/Fe3O4 as Ion-Electron Transduction Layer to Manufacture All-Solid-State Ion-Selective Electrode for Determination of Serum Potassium”. Chemosensors, 2021, 9(7), 155. Liang, Z.; Yang, Y.; Yu, G.; Zhu, H.; Xia, X.; Chen, C.; Fu, D.; Li, M.; Cheng, G.; Xue, C.; Shi, L.; Zeng, H*; Sun, B*. “Engineered Aluminum Phosphate Nanoparticles with Well-Controlled Surface Property as Effective Vaccine Adjuvants”. Biomaterials, 2021, 275, 120960. Liang, Z.; Zhu, H.; Wang, X.; Jing, B.; Li, Z.; Xia, X.; Sun, H.; Yang, Y.; Zhang, W.; Shi, L.; Zeng, H*; Sun, B*. “Adjuvants for Coronavirus Vaccines”. Frontiers in Immunology, 2020, 11, 589833. Ma, T.; Wang, X.; Li, L.; Sun, B.; Zhu, Y.*; Xia, T*. “Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-κB mediated acute lung inflammation in mice”. Archives of Toxicology, 2020. Shi, S.; Liang, Z.; Sun, B*. “Response to Comment on: Vaccine Adjuvants: Understanding the Structure and Mechanism of Adjuvanticity”. Vaccine, 2020, 38(13), 2759. Ji, E.; Elzakra, N.; Chen, W.; Cui, L.; Lee, E.; Sun, B.; Messadi, D.; Xia, T.; Zhu Y.; Hu, S*.“E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes”. Journal of Cancer, 2019, 10(27), 6915-6924. Cui, L.; Wang, X.; Sun, B.; Xia, T.*; Hu, S*. “Predictive Metabolomic Signatures for Safety Assessment of Metal Oxide Nanoparticles”. ACS Nano, 2019, 13(11), 13065-13082. Li, M.; Cheng, F.*; Xue, C.; Wang, H.; Chen, C.; Du, Q.; Ge, D.; Sun, B*. “Surface Modification of Stöber Silica Nanoparticles with Controlled Moiety Densities Determines Their Cytotoxicity”. Langmuir, 35(45), 14688-14695. Feng, Y.; Wang, L.; Chang, Y.; Cheng, Y.; Sun, B.; Wang, L.*; Chen, C.; Zhang, H*. “Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@Ag Core–Shell Nanoparticles”. Nano Letters, 2019, 19 (7), 4478-4489. Du, Q.; Ge, D.; Vahid, M.; Chen, C.; Li, M.; Xue, C.; Ma, X.; Sun, B*. “Assessment of Neurotoxicity Induced by Different-Sized Stöber Silica: Induction of Pyroptosis in Microglia”. Nanoscale, 2019, 11, 12965-12972. Ge, D.; Du, Q.; Ran, B.; Liu, X.; Wang, X.; Ma, X.; Cheng, F.; Sun, B*. “The Neurotoxicity Induced By Engineered Nanomaterials” International Journal of Nanomedicine, 2019, 14, 4167-4186. Shi, S.; Zhu, H.; Xia, X.; Liang, Z.; Ma, X.; Sun, B.* "Vaccine Adjuvants: Understanding the Structure and Mechanism of Adjuvanticity". Vaccine, 2019, 37 (24), 3167-3178. Cheng, F.*; Wang, H.; He, W.; Sun, B.; Zhao, J.; Qu, J; Wang, Q.“New Strategy for Functionalization of Silica Materials viaCatalytic Oxa-Michael Reaction of Surface Silanol Groups with Vinyl Sulfones”. ACS Sustainable Chemistry & Engineering, 2019, 7 (10), 9112-9120. Cheng, F.*; Li, M.; He, W.; Sun, B.; Qin, J.; Qu, J.“Activation of Resin with Controllable Ligand Density via Catalytic oxa-Michael Addition and Application in Antibody Purification”. Journal of Chromatography A, 2018, 1570 (5), 1-9. Mirshafiee, V*.; Sun, B.*; Chang, C.H.; Jiang, W.; Jiang, J.; Liu, X.; Liao Y.-P.; Wang, X.; Nel, A.E.; Xia, T. “Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes”. ACS Nano, 2018, 12 (4), 3836-3852. *Equal contribution. Li, R.; Guiney, L.; Chang, C.H.; Mansukhani, N.; Ji, Z.; Wang, X.; Liao Y.-P.; Jiang, W.; Sun, B.; Hersam, M.; Nel, A.; Xia, T. “The Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model”. ACS Nano, 2018, 12 (2), 1390-1402. Lu, J.; Liu, X.; Liao Y.-P.; Bergara, F.; Sun, B.; Jiang, W.; Chang, C.H., Jiang, J.; Wang, X.; Wu, A.; Meng, H.; Nel, A.E. “Nano-enabled Pancreas Cancer Immunotherapy using Immunogenic Cell Death and Reversing Immunosuppression”. Nature Communications, 2017, DOI: 10.1038/s41467-017-01651-9. Sun, B.*; Ji, Z.; Liao, Y.-P.; Chang, C.H.; Justine, K.; Wang, X.; Mirshafiee, V.; Xue, C.; Xia, T*. “Enhanced immune adjuvant activity of aluminum oxyhydroxide nanorods through cationic surface functionalization”. ACS Applied Materials & Interfaces, 2017, 9 (26), 21697-21705. *Corresponding author. Mirshafiee, V.; Jiang, W.; Sun, B.; Wang, X.; Xia, T. “Facilitating translational nanomedicine via predictive safety assessment”. Molecular Therapy, 2017, 25 (7), 1522-1530. Wang, X.*; Sun, B.*; Liu, S.; Xia, T. “Structure activity relationships of engineered nanomaterials in inducing NLRP3 inflammasome activation and chronic lung fibrosis”. NanoImpact, 2017, 6, 99-108. *Equal contribution. Jiang, W.; Wang, X.; Du, Y.; Chang, C.H.; Liao, Y-P.; Osberne, O.; Sun, B.; Jiang, J.; Ji, Z.; Li, R.; Liu, X.; Lu, J.; Lin, S.; Meng, H.; Xia, T.; Nel, A.E. “Pro-inflammatory and pro-fibrogenic effects of ionic and particulate arsenide and indium-containing semiconductor materials in the murine lung”. ACS Nano, 2017, 11 (2), 1869-1883. Chen, Y.; Wu, Y.; Sun, B.; Liu, S; Liu, H. “Two-dimensional nanomaterials for cancer nanotheranostics”. Small, 2017, 13 (10), 1603446.