邵堃 - 大连理工大学

个人简介

2004.09-2008.04 厦门大学医学院，药学学士 2008.09-2013.06 复旦大学药学院，药剂学博士 2013.09-2018.04 加拿大卡尔加里大学医学院，免疫学博士后 2018.07-至今大连理工大学精细化工国家重点实验室，教授、博导

研究领域

1. 智能纳米药物 2. 免疫治疗纳米疫苗 3. 声动力治疗药物 4.硼中子俘获治疗药物

近期论文

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Huang J, Sun X, Wang Y, Su J, Li G, Wang X, Yang Y, Zhang Y, Li B, Zhang G, Li J, Du J, Nanjundappa RH, Umeshappa CS*, Shao K*. Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems. Ecotoxicol Environ Saf. 2023, 264:115447. Wang L. Li G*, Cao L, Dong Y, Wang Y, Wang S, Li Y, Guo X, Zhang Y, Sun F, Du X, Su J, Li Q, Peng X, Shao K*, Zhao W*. An Ultrasound-Driven Immune Boosting Molecular Machine for Systemic Tumor Suppression. Sci Adv, 2021, 7:eabj4796. Xia W, Li H, Li Y, Li M, Fan J, Sun W, Li N, Li R, Shao K*, Peng X*. In Vivo Coinstantaneous Identification of Hepatocellular Carcinoma Circulating Tumor Cells by Dual-Targeting Magnetic-Fluorescent Nanobeads. Nano Lett. 2021. 21(1):634-641. Xia W, Shangguan X, Li M, Wang Y, Xi D, Sun W, Fan J, Shao K*, Peng X*. Ex vivo identification of circulating tumor cells in peripheral blood by fluorometric "turn on"aptamer nanoparticles. Chem Sci. 2021. 12:3314-3321. Qin L#, Cao J#, Shao K#(共一), Tong F, Yang Z, Lei T, Wang Y, Hu C, Umeshappa CS, Gao H*, Peppas NA. A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis. Sci Adv. 2020. 6(36):eabb3116. Singha S#, Shao K#(共一), Ellestad KK, Yang Y, Santamaria P*. Nanoparticles for Immune Stimulation Against Infection, Cancer, and Autoimmunity. ACS Nano. 2018. 12(11):10621-10635. Singha S#, Shao K#(共一), Yang Y*, Clemente-Casares X, Sole P, Clemente A, Blanco J, Dai Q, Song FY, Liu S, Yamanouchi J, Umeshappa C, Nanjundappa R, Detampel P, Amrein M, Fandos C, Tanguay R, Newbigging S, Serra P, Khadra A, Chan W, Santamaria P*. Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices. Nat Nanotechnol. 2017. 12(7):701-710. Shao K, Singha S, Clemente-Casares X, Tsai S, Yang Y, Santamaria P*. Nanoparticle-based immunotherapy for cancer. ACS Nano. 2015. 9(1):16-30. （ESI高被引） Shao K, Zhang Y, Ding N, Huang S, Wu J, Li J, Yang C, Leng Q, Ye L, Lou J, Zhu L*, Jiang C*. Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications. Adv Healthc Mater. 2015. 4(2):291-300. Shao K, Ding N, Huang S, Ren S, Zhang Y, Kuang Y, Guo Y, Ma H, An S, Li Y, Jiang C*. Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy. ACS Nano. 2014. 8(2):1191-203. Shao K, Wu J, Chen Z, Huang S, Li J, Ye L, Lou J, Zhu L*, Jiang C*. A brain-vectored angiopep-2 based polymeric micelles for the treatment of intracranial fungal infection. Biomaterials. 2012. 33(28):6898-907. Shao K, Huang R, Li J, Han L, Ye L, Lou J, Jiang C*. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J Control Release. 2010. 147(1):118-26.