个人简介
教育背景: 2002.9-2006.6 天津大学化工学院,学士(生物工程专业) 2006.9-2008.6 天津大学化工学院,硕士(生物化工专业 导师:赵学明教授) 2008.9-2012.11瑞典查尔摩斯大学,博士(系统及合成生物学专业 导师:Jens Nielsen 教授) 工作经历: 2013.1-2017.8:新加坡科技研究局 科学家I 2017.9-至今:北京化工大学科学与技术学院 副教授 2019. 1-至今:北京化工大学科学与技术学院生物工程系主任
研究领域
实验室主要研究方向为代谢工程、系统生物学、合成生物学,具体包括: 1. 细胞机理 2. 细胞工厂 3. 系统与合成生物学工具的开发
近期论文
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1. Zhang Y, Wang J, Wang Z, Zhang Y, Shi S, Nielsen J, Liu Z#. A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae. Nature Commun., 2019, 10(1): 1053. (IF=11.878)
2. Liu Z, Zhang Y, Nielsen J#. Synthetic biology of yeast. Biochemistry, 2019, 58(11), 1511-1520. (IF=2.952)
3. Zhang Y, Nielsen J, Liu Z#. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived hydrocarbons. Biotechnol. Bioeng., 2018, 11(9), 2139-2147. (IF=4.26)
4. Zhang Y, Nielsen J, Liu Z#. Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels. FEMS Yeast Res., 2017, 17 (8), fox080 (IF=2.458)
5. Liu Z, Liang Y, Ang EL#, Zhao H#. The New Era of Genome Integration – Simply Cut and Paste! ACS Syn. Biol., 2017, 6, 601−609. (IF=5.571)
6. Liang J*, Liu Z*, Ang EL#, Zhao H#. Twin-primer non-enzymatic DNA assembly: an efficient and accurate multi-part DNA assembly method. 2017. Nucleic Acids Res., 45 (11): e94. (IF=11.147)
7. Sun H*, Liu Z*, Zhao H, Ang EL#. Recent advances in combinatorial biosynthesis for drug discovery. Drug Des. Dev. Ther., 2015, 9:823—833. *Equal contribution. (IF=3.208)
8. Liu Z, Liu L, Österlund T, Hou J, Huang M, Fagerberg L, Petranovic D, Uhlén M, Nielsen J#. Improved production of a heterologous amylase in yeast by inverse metabolic engineering. Appl. Environ. Microbiol., 2014, 80(17):5542-5550. (IF=4.077)
9. Liu Z, Österlund T, Hou J, Petranovic D, Nielsen J#. Anaerobic α-Amylase production and secretion with fumarate as the final electron acceptor in Saccharomyces cerevisiae. 2013. Appl. Environ. Microbiol., 79(9): 2962-2967. (IF=4.077)
10. Liu Z, Hou J, Martínez JL, Petranovic D, Nielsen J#. Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae. 2013. Appl. Microbiol. Biotechnol., 97(20): 8955-8962. (IF=3.67)
11. Liu Z, Tyo KE, Martínez JL, Petranovic D, Nielsen J#. Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. 2012. Biotechnol. Bioeng., 109(5): 1259-1268. (IF=4.26)
12. Hou J*, Tyo KE*, Liu Z*, Petranovic D, Nielsen J#. Metabolic engineering of recombinant protein production by Saccharomyces cerevisiae. 2012. FEMS Yeast Res, 12(5): 491-510. *Equal contribution. (IF=2.458)