李灏 - 北京化工大学 - 生命科学与技术学院

个人简介

教育背景： 1995-1999 山东大学微生物学专业理学学士 1999-2002 山东大学微生物学专业理学硕士 2002-2005 中国海洋大学海洋生物学专业理学博士工作经历： 2005-2008 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，博士后研究工作 2008至今北京化工大学生命科学与技术学院

研究领域

1、生物乙醇发酵过程中乙醇胁迫问题（胁迫机制、如何提高乙醇耐受性）； 2、生物乙醇发酵过程中染菌问题（利用生物法防控杂菌污染、杂菌污染对酿酒酵母细胞代谢及社会行为学的影响）； 3、代谢组学及其应用； 4、核酸适配体筛选及其应用。

近期论文

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Ye Duan, Lihui Wang, Zhiqiang Gao, Huishan Wang, Hexiao Zhang, Hao Li*. An aptamer-based effective method for highly sensitive detection of chloramphenicol residues in animal-sourced food using real-time fluorescent quantitative PCR. Talanta, 2017, 165: 671-676. (*通讯作者) Bo Liu, Huaqing Liu, Yunxiao Zhang, Hao Li*. Control of Lactobacillus plantarum contamination in bioethanol fermentation by adding plantaricins. International Journal of Agricultural & Biology, 2017, 19: 171-176. (*通讯作者) Juan Tian, Shuxian Zhang, Hao Li*. Changes in intracellular metabolisms underlying the adaptation of Saccharomyces cerevisiae strains to ethanol stress. Annals of Microbiology, 2017, 67 (2): 195-202. (*通讯作者) 2016年文章： Ze Chen, Zhou Zheng, Chenfeng Yi, Fenglian Wang, Yuanpu Niu, Hao Li*. Intracellular metabolic changes of Saccharomyces cerevisiae and promotion to ethanol tolerance during the bioethanol fermentation process. RSC Advances, 2016, 6: 105046-105055. (*通讯作者) Yuanpu Niu, Xianghua Lin, Shijun Dong, Qipeng Yuan, Hao Li*. Indentation with atomic force microscope, Saccharomyces cerevisiae cell gains elasticity under ethanol stress. International Journal of Biochemistry and Cell Biology, 2016, 79: 337-344. (*通讯作者) Yanfeng Wang, Juan Tian, Zhihua Ji, Maoyong Song, Hao Li*. Intracellular metabolic changes of Clostridium acetobutylicum and promotion to butanol tolerance during biobutanol fermentation. International Journal of Biochemistry and Cell Biology, 2016, 78: 297-306. (*通讯作者) Ye Duan, Zhiqiang Gao, Lihui Wang, Huishan Wang, Hexiao Zhang*, Hao Li*. Selection and identification of chloramphenicol specific DNA aptamers by Mag-SELEX. Applied Biochemistry and Biotechnology, 2016, 180 (8): 1644-1656. (*通讯作者) Chenfeng Yi, Fenglian Wang, Shijun Dong, Hao Li*. Changes of trehalose content and expression of relative genes during the bioethanol fermentation by Saccharomyces cerevisiae. Canadian Journal of Microbiology, 2016, 62 (10): 827-835. (*通讯作者) 2015年文章: Shijun Dong, Chenfeng Yi, Hao Li*. Changes of Saccharomyces cerevisiae cell membrane components and promotion to ethanol tolerance during the bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 69: 196-203. (*通讯作者) Fengxia Cui, Huaqing Liu, Zhongmei Zou, Hao Li*. Metabolic responses to water deprivation in C57BL/6J mice using a proton nuclear magnetic resonance-based metabonomics approach. RSC Advances, 2015, 5, 80142-80149. DOI: 10.1039/C5RA12650A. (*通讯作者) Fengxia Cui, Ruimin Zhang, Hua1ing Liu, Yanfeng Wang, Hao Li*. Metabolic responses to Lactobacillus plantarum contamination or bacteriophage treatment in Saccharomyces cerevisiae using a GC-MS-based metabolomics approach. World Journal of Microbiology & Biotechnology, 2015, 31(12): 2003-2013. (*通讯作者) RiBang Wu, CuiLing Wu, Dan Liu, XingHao Yang, JiaFeng Huang, Jiang Zhang, Binqiang Liao, HaiLun He, Hao Li*. Overview of antioxidant peptides derived from marine resources: the sources, characteristic, purification, and evaluation methods. Applied Biochemistry and Biotechnology. 2015, 176 (7), 1815-1833. (*通讯作者) Shijun Dong, Xianghua Lin, Hao Li*. Regulation of Lactobacillus plantarum contamination on the carbohydrate and energy related metabolisms of Saccharomyces cerevisiae during bioethanol fermentation. Int J Biochem Cell Biol. 2015 Aug 14; 68: 33-41. (*通讯作者) Xianghua Lin, Pei Han, Shijun Dong, Hao Li*. Preparation and application of bacteriophage-loaded chitosan microspheres for controlling Lactobacillus plantarum contamination in bioethanol fermentation. RSC Advances, 2015, 5: 69886-69893. (*通讯作者) Yanfeng Wang, Shuxian Zhang, Huaqing Liu, Lei Zhang, Chenfeng Yi, Hao Li*. Changes and roles of membrane compositions in the adaptation of Saccharomyces cerevisiae to ethanol. Journal of Basic Microbiology, 2015, 55 (12): 1417-1426. (*通讯作者) Dan Liu, XingHao Yang, JiaFeng Huang, RiBang Wu, CuiLing Wu, HaiLun He, Hao Li*. In situ demonstration and characteristic analysis of the protease components from marine bacteria using substrate immersing zymography. Applied Biochemistry and Biotechnology, 2015, 175 (1): 489-501. Short title: Analysis of protease by immersing zymography. (*通讯作者)