陈强 - 兰州大学 - 甘肃省新药临床前研究重点实验室

个人简介

陈强，男，1963年4月生，教授，博士生导师。1983年本科毕业于兰州大学生物系动物学专业，1990年获动物生态学硕士学位，2001年获生物化学博士学位。1995－1996年作为访问学者赴意大利国家野生动物研究所学习分子生物学技术，2001－2002年在加拿大圭尔夫大学作博士后。现任兰州大学生命科学学院副院长，生物学实验教学中心（国家级实验示范中心）主任、国家基础科学研究与教学人才培养基地兰州大学生物学基地点负责人。主要从事动物生理生化和多肽生物化学的教学和科研工作。在动物生理学方面，主要研究西北野生动物的繁殖、遗传、性别分化、代谢率等活动与环境因子的关系，及其生理调节及活动规律等。近年来主要从事神经肽的合成、药理以及构效关系方面的研究，主要涉及几种神经肽和类似物的合成、构效关系及药理学作用，以及多肽在痛觉调节、心血管活动以及糖尿病模型动物中的作用及相关机理。近年来在国内外刊物上发表论文28篇，其中SCI收录15篇。

研究领域

动物生理生化及多肽生化药理学

近期论文

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9. 吴宁, 霍笑风, 陈强, 杨顶建, 王锐* (2001) 侧脑室注射内吗啡肽-1对麻醉大鼠血压的影响. 药学学报 36(10): 731' 10.吴宁, 任维华, 霍笑风, 陈强, 王锐* (2001) 内吗啡肽及其类似物对心血管系统的作用. 药学学报 36(4): 241 11. 陈勇, 陈鲤翔, 陈强, 杨顶建, 彭雅丽, 杨祺, 王锐* (2001) 痛稳素碳末端八肽翻转孤啡肽对抗吗啡镇痛的作用. 中国药理学通报17(4): 383 12. Chen Q, Chen Y, Chen LX, Yang DJ, Dong SL, Wang Rui* (2001) The effects of the synthetic nocistation on blood vessel activities. Chin. Sci. Bull. 46(8): 275 13. Lin X, Cai YJ, Li ZX, Chen Q, Wang Rui*(2003) Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata. Biochim. Biophys. Acta. 1622: 99 14. Lin X, Yang DJ, Cai WQ, Zhao QY, Gao YF, Chen Q, Wang Rui*(2003) Endomorphins, endogenous opioid peptide, provide antioxidant defense in the brain against free radicall-induced damage. Biochim. Biophys. Acta (BBA)-Mol. Basis. Dis. 1639: 195 15. Li-xiang Chen, Quan Fang, Qiang Chen*, Jia Guo, Zhuan-zi Wang, Yong Chen, Rui Wang? 　Study in vitro and in vivo of nociceptin/orphanin FQ(1–13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. Peptides, 2004,25, 1349-1354 16. Pei-Han Xu, Min Chang, Li-Xiang Chen, Qiang Chen*, Xiang Yan*, Rui Wang* The relaxant Effect of nociceptin on porcine coronary arterial ring segment. Can. J. Physiol. Pharmacol., 2004, 82, 993-999 17. Xin Lin, Qiang Chen, Li-Ying Xue, Xiao-Jun Ma, and Rui Wang. Endomorphins, endogenous opioid peptides induce apoptosis in human leukemia HL-60 cells. Can. J. Physiol. Pharmacol. 2004,82, 1018-1025 18. Yun Feng, Qian-Yu Zhao, Qiang Chen, Rui Wang* (2005) Vasorelaxant responses to endomorphin1[?] and endomorphine2[?], analogues of endomorphins, in rat aorta rings. pharmazie 60:851-855 19. Cai-Yun Fu, Zi-Qing Kong, Kai-Rong Wang, Qi Yang, Kui Zhai,Qiang Chen,*　Rui Wang*　Effects and mechanisms of supraspinal administration of rat/mouse　hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Research, 2005,1056, 51-58 20. Qian-Yu Zhao, Qiang Chen, Ding-Jian Yang, Yun Feng, Yuan Long, Peng Wang, Rui Wang, Endomorphin 1[c] and endomorphin 2[c], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception. Life Sci., 2005,77, 1155-1165 21. Qian-Yu Zhao, Qiang Chen, Yun Feng, Xin Lin and Rui Wang* [TIC4] endomorphins, analogues of endomorphins, have significantly　nhanced vasorelaxant effects in rat aorta rings. Protein Pept. Lett. 2005,12(4), 323-326 22. Pei-Han Xu, Qiang Chen, Hong-Fang Li, Ye Yu, Xiang Yan, Rui Wang* The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie 2005, 60 375-377 23. 欧阳建梅陇源房克难王锐陈强*, 蜂胶乙醇提取物(EEP)对豚鼠胸主动脉的舒张作用, 现代生物医学进展 2007(9):1286-1289 24. Kui Zai, Li Hu, Juan Chen, Caiyun Fu, Qiang Chen* Chrysin induced hyperalgesia via GABAA receptor in mice. Planta Medica 2008; 74:1229-1234 25. Juan Chen，Yuan Long，Min Han，Ting Wang, Qiang Chen*, Rui Wang* Water-solutable derivates of propolis mitigates scopolamine-induced learning and memory impairment in mice.Pharmacology, Biochemistry and Behavior 2008; 90:441-446 26. Lai-Fu Li, Yan-Yu Lu, Wei Xiong, Juan-Ying Liu, Qiang Chen* Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice. European Journal of Pharmacology (available online), 595 (2008) 90–94 27. Ning Xu, Haiting Wang, Li Fan, Qiang Chen* Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice.Peptides, in press, available online 24 February 2009 28. Xiao-zhu Tian, Juan Chen, Wei Xiong, Tian He, Qiang Chen* Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides,30 (2009) 1348–1354