马毅 - 华南理工大学 - 生物科学与工程学院

个人简介

2016/09 -至今华南理工大学生物科学与工程学院，副教授； 2012/12-2016/08 华南理工大学生物科学与工程学院，讲师； 2009/08-2011/08 德国法兰克福大学，生物物理化学学院，联合培养博士； 2007/09-2012/06 华南理工大学，微生物学，理学博士； 2004/09-2007/06 湖南大学，生物化学与分子生物学，理学硕士；

研究领域

主要致力于建立和发展无细胞反应工程体系，用于重要药物靶标膜蛋白的高效表达和纯化，功能表征，配体筛选以及高分辨三维结构的解析；新型抗菌肽的设计，改造以及工业化生产，开发和制备新型高效、广谱和对人体低毒副作用的抗菌药物；优化大肠杆菌、毕赤酵母菌、枯草芽孢杆菌和乳酸乳球菌等工程菌株，用于合成外源重组蛋白质，研发清除体内重金属和自由基，防衰老以及抗辐射的功能性食品和保健品。

近期论文

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[1]. Erik Henrich, Yi Ma*, Ina Engels, Daniela Münch, Christian Otten, Tanja Schneider, Beate Henrichfreise, Hans-Georg Sahl, Volker Dötsch and Frank Bernhard.Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid Ⅱ Synthesis Pathway. Journal of Biological Chemistry, 291(5): 2535-2546, 2016. （通讯作者，生物化学领域Top期刊，SCI 收录） [2]. Yi Ma,Daniela Münch, Tanja Schneider, Hans-Georg Sahl, Ahmed Bouhss, Umesh Ghoshdastider, Jufang Wang, Volker Dötsch, Xiaoning Wang* and Frank Bernhard*.Preparative Scale Cell-free Production and Quality Optimization of MraY Homologues in Different Expression Modes. The Journal of Biological Chemistry, 286 (45): 38844-38853, 2011.（生物化学领域Top期刊，SCI 收录） [3]. Meng Wang, Minhua Huang, Huawei Gu, Shan Li, Yi Ma* and Jufang Wang. Mutational Analysis to Identify the Residues Essential for the Acetyltransferase Activity of GlmU in Bacillus subtilis.RSC Advances, 7(23): 13858-13867, 2017.（通讯作者，SCI 收录） [4]. Yi Ma, Chao Ni, Emmanuel E. Dzakah, Haiying Wang, Keren Kang, Shixing Tang, Jihua Wang, and Jufang Wang. Development of Monoclonal Antibodies against HIV-1 p24 Protein and its Application in Colloidal Gold Immunochromatographic Assay for HIV-1 Detection.BioMed Research International, 6743904, 6 pages, 2016.（SCI 收录） [5]. Yi Ma, Jieying Yu, Jinglian Lin, ShaominWu, Shan Li, and JufangWang. High Efficient Expression, Purification and Functional Identification of Native Human Epidermal Growth Factor in Escherichia coli.BioMed Research International, 3758941, 7 pages, 2016.（SCI 收录） [6]. Yi Ma, Beilei Zhang, Meng Wang, Yanghui Ou, Jufang Wang, and Shan Li. Enhancement of Polymerase Activity of the Large Fragment in DNA Polymerase I from Geobacillus stearothermophilus by Site-Directed Mutagenesis at the Active Site. BioMed Research International, 2906484, 8 pages, 2016.（SCI 收录） [7]. Yi Ma, Umesh Ghoshdastider, Jiufang Wang, Volker Dötsch, Frank Bernhard and Xiaoning Wang. Cell-free Expression of Human Glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for Inhibitor Screening. Protein Expression and Purification, 86 (2):120-126, 2012.（SCI 收录） [8]. Wei Ye#, Yi Ma#, Haiying Wang, Xiaochun Luo, Weimin Zhang, Jufang Wang*, Xiaoning Wang. A New Strategy for Recovery of Bioactive Peptide Employing Glutamate-specific Endopeptidase from Bacillus licheniformis. Enzyme and Microbial Technology. 54: 25-31, 2014.（共同第一作者，SCI 收录） [9]. Ji Liu#, Yi Ma#, Chun-Li Sun, Shan Li, and Ju-Fang Wang. High Mobility Group Box1 Protein is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A.BioMed Research International, , 4130834, 7 pages, 2016.（共同第一作者，SCI 收录） [10]. Yanfang Su, Jing Yang, Meng Wang, Shaomin Wu, Yi MA*, Shan Li, and Jufang Wang. Efficient and Functional Expression of cA-GFP Fusion Protein in Escherichia coli. Modern Food Science and Technology, 31(12): 128-133, 2015（通讯作者，EI 收录）