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个人简介

教育背景: 1996—1999,中山大学应用力学与工程系,获流体力学专业硕士学位; 1982—1986,武汉水运工程学院船舶工程系,获工学学士学位。 工作经历: 2007—至今,华南理工大学生物科学与工程学院;副教授; 2003—2006,中山大学生命科学学院生物化学系,讲师; 2001-2003,美国乔治亚理工学院机械工程系(生物科学与生物工程中心),访问科学家; 2001年以前,历任北京大学力学系、中山大学应用力学工程系助理研究员和讲师等。

研究领域

在循环血流中,受体—配体相互作用及其所介导的免疫细胞(如血小板、白细胞等)胞内信号转导、相关分子的黏附和聚集等。力图在基因、蛋白、细胞与组织水平,揭示困扰人类健康的重大疾病(如心脑血管疾病与癌症转移等)发生的生(病)理机制,相关信号通路与分子结构基础,旨在为相关疾病的个性化介入治疗和分子靶向药物设计提供新的思路和有用线索。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Xiang Fang, Ying Fang*, Li Liu, Guangjian Liu, Jianhua Wu. 2012. Mapping Paratope on Antithrombotic Antibody 6B4 to Epitope Platelet Glycoprotein Ibalpha via Molecular Dynamic Simulations. PLoS ONE 7(7): e42263. 2. Quhuan Li, Ying Fang, Xiaoru Ding, Jianhua Wu. 2012. Force-dependent bond dissociation govern rolling of HL-60 cells through E-selectin. Experimental Cell Research. 318(14): 1649-1658 3. 严翠婷,黄庆生,章芬,方颖*,2012, 基于图像配准分析物种进化关系的新方法,基因组学与应用生物学,31(3): 212-221 4. Liu, L., Y. Fang, Q. Huang and J. Wu. 2011. A rigidity-enhanced antimicrobial activity: a case for linear cationic α-helical peptide HP(2–20) and its four analogues. PLoS ONE 6(1): e16441. 5. Sun, T., Q. Huang, Y. Fang and J. Wu. 2011. FurinDB: A database of 20-Residues furin cleavage site matiffs, substrates and their associated druges. Int. J. Mol. Sci. 12(2): 1060-1065. 6. X. Fang, Y. Fang and J. Wu. 2011. Computational modeling of the Antithrombotic Antibody SZ2 in complex with GPIbα. Proc. of 5th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), May 10-12, 2011. Wuhan, China. (10.1109/icbbe.2011.5780046) 7. G. Liu, Y. Fang and J. Wu. 2011. Type 2B Mutations Destabilize VWF A1 Domain: A Molecular Dynamics Simulation Study. Proc. of 5th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), May 10-12, 2011. Wuhan, China. (10.1109/icbbe.2011.5780047) 8. Y.Xiang, Y.Fu, J. Wu, Y.Fang and S.Feng. 2011. Analysis of high-frequency risk factors among patients with Coronary Heart Disease in Guangzhou. Proc. of 5th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), May 10-12, 2011. Wuhan, China. (10.1109/icbbe.2011.5781613) 9. 项钰,吴建华,方颖,冯常森,2011. 广州地区心血管病患者危险因子与血脂水平的分析. 广东医学.32(9):1185-1188 10. 黄强, 凌颖琛, 李趣欢, 吴建华, 方颖. 2010.通过流动腔实验测量HL-60细胞微绒毛弹性.医用生物力学.25(4):19-24. 11. Y. Fang, J. Wu, R.P. McEver and C. Zhu. 2009. Bending rigidities of cell surface molecules P-selectin and PSGL-1, J. of Biomechanics, 42: 303-307. 12. L. Liu, Q. Huang, Y. Fang, J. Wu. 2009. Flexibility, a possible dominate factor on the activity of antimicrobial peptides. Proc. of the 4th WACBE World Congress on Bioengineering 2009. p308. (第九届世界华人生物医学工程大会)荣获WACBE Young Investigator Award。WACBE青年科学家奖. 13. Tolentino, T.P, J. Wu, V.I. Zarnitsyna, Y. Fang, M.L. Dustin and C. Zhu. 2008. Measuring diffusion and binding kinetics by contact area FRAP. Biophysical Journal. 95(2): 920-930 14. Wu, J, Y. Fang, V.I. Zarnitsyna, T.P. Tolentino, M.L. Dustin and C. Zhu. 2008. A coupled diffusion- kinetics model for analysis of contact area FRAP experiment. Biophysical Journal. 95(2): 910- 919. 15. 方颖, 吴建华. 2008. 受弹性生物试件约束的矩形AFM悬臂梁的热响应. 生物医学工程学杂志. 24(4): 829-834 16. 方颖, 凌颖琛, 向雪, 吴建华. 2008. 靶心型细胞接触面FRAP的理论数值模拟. 医用生物力学. 22(2): 185-191 17. 方颖,向雪,凌颖琛,吴建华. 2008. “细胞接触面内的扩散阻塞效应的估计”. 医用生物力学. 22(1): 30-34 18. Y. Fang, Y. Lao, Q. Li, C. Zhu and J. Wu. 2008, “A Theoretical Model for Binary Adhesion of Cells in Flows”. IFMBE Proc. 19:164-166 19. L. Liu, Y. Fang, Q. Huang, Q. Pan and J. Wu. 2008, “A New Structure-Activity Relationship of Linear Cationic α-helical Antimicrobial Peptides”, IFMBE Proc. 19:167-170 20. Y. Lao, J. Lin, Y. Fang, Q. Li, C. Zhu and J. Wu. 2008, “Numerical Simulations of Colliding Particle Distribution in Flow Chamber”. IFMBE Proc. 19:171-173

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