郭沛 - 华南理工大学 - 生物科学与工程学院

个人简介

教育背景： 2008. 09 - 2012. 07：华中师范大学化学学院学士（化学与英语双学位） 2012. 08 - 2016. 11：香港中文大学化学学院博士工作经历： 2016. 11 - 2019. 05：香港中文大学化学学院博士后 2019. 05至今：华南理工大学生物科学与工程学院副教授

研究领域

研究主要集中但不局限于：（1）核酸分子（DNA和RNA）的结构、生物、物理及化学性质；（2）高分辨率液体核磁共振（NMR）测定核酸及其他生物分子的三维空间结构；（3）人类神经退行性疾病中基因不稳定性的机理；（4）生物药物靶向作用的机制及药物设计；（5）单分子技术研究生物大分子的生理学性质。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Guo, P.; Lam, S. L., Unprecedented hydrophobic stabilizations from a reverse wobble T·T mispair in DNA minidumbbell. Journal of Biomolecular Structure & Dynamics, 2019, DOI: 10.1080/07391102.2019.1621211. 2. Guo, P.; Chan, H. Y. E.; Lam, S. L., Conformational flexibility in the RNA stem-loop structures formed by CAG repeats. FEBS Letters, 2017, 591 (12), 1752-1760. 3. Guo, P.; Lam, S. L., An extraordinarily stable DNA minidumbbell. Journal of Physical Chemistry Letters,2017, 8 (15), 3478-3481. 4. Liu, Y.; Guo, P.; Lam, S. L., Formation of a DNA mini-dumbbell with a quasi-type II loop. Journal of Physical Chemistry B, 2017, 121 (12), 2554-2560. 5. Griffith, J. F.; Hu, M.; Yeung, D. K. W.; Guo, P.; Lam, S. L.; Xiao, F.; Wang, D.; Tomlinson, B., Achilles Tendon Xanthomas: Fat-Water Separation at Baseline and after Treatment. Radiology, 2017, 285 (3), 876-884. 6. Guo, P.; Lam, S. L., Minidumbbell: A new form of native DNA structure. Journal of the American Chemical Society, 2016, 138 (38), 12534-12540. 7. Guo, P.; Lam, S. L., The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion. Signal Transduction and Targeted Therapy, 2016, 1, 16028. 8. Guo, P.; Lam, S. L., Unusual structures of CCTG repeats and their participation in repeat expansion. Biomolecular Concepts, 2016, 7 (5-6), 331-340. 9. Guo, P.; Lam, S. L., New insights into the genetic instability in CCTG repeats. FEBS Letters, 2015, 589 (20 Pt B), 3058-3063. 10. Guo, P.; Lam, S. L., Unusual structures of TTTA repeats in icaC gene of Staphylococcus aureus. FEBS Letters, 2015, 589 (12), 1296-1300. 11. Yao, S.; Tam, D. Y.; Cheung, P. S.; Lam, C. K.; Guo, P.; Lam, S. L.; Lee, H. K., Cobalt(II) amido complexes derived from a monodentate arylamido ligand featuring a highly electron-withdrawing C6F5 substituent. Dalton Transactions, 2015, 44 (41), 17950-17959. 12. Guo, P.; Wang, Q.; Liu, J.; Liu, L.; Zhao, P.; Cao, Y.; Liu, Y.; Qi, C.; Liu, Y., Preparation of two organoselenium compounds and their induction of apoptosis to SMMC-7221 cells. Biological Trace Element Research, 2013, 154 (2), 304-311. 13. Guo, P.; Zhao, P.; Liu, J.; Ma, H.; Bai, J.; Cao, Y.; Liu, Y.; He, H.; Qi, C., Preparation of a novel organoselenium compound and its anticancer effects on cervical cancer cell line HeLa. Biological Trace Element Research, 2013, 151 (2), 301-306. 14. Chen, D.; Guo, P.; Chen, S.; Cao, Y.; Ji, W.; Lei, X.; Liu, L.; Zhao, P.; Wang, R.; Qi, C.; Liu, Y.; He, H., Properties of xyloglucan hydrogel as the biomedical sustained-release carriers. Journal of Materials Science: Materials in Medicine, 2012, 23 (4), 955-962.