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个人简介

学习经历 1995.9-1999.7:华南农业大学 畜牧 学士 1999.9-2002.7:华南农业大学 动物遗传育种 硕士 2002.9-2005.7:华南农业大学 动物遗传育种 博士 2003.8-2003.10:华中农业大学动物遗传国家重点实验室学习基因组相关技术 工作经历 2006.1-2009.8 华南理工大学 讲师 2006.5-2006.8 中国医学科学院生物技术研究所进修 2009.9-2015.8 华南理工大学 副教授 2015.9-至今 华南理工大学 教授

研究领域

(1)重大疾病潜在生物标志物和靶标研究:随着组学技术的快速发展,国际积累了海量的组学数据,利用交叉学科的思维和系统生物学方法从各个层次去揭示疾病发病机制,鉴定其潜在的生物标志物和靶标,课题组目前主要在2型糖尿病和结核感染等方面开展研究工作;(2)高通量基因组技术在疾病预测预防中的应用:利用高通量组学技术在重大老年病及肿瘤的预测、预防上做些前瞻性的研究。

近期论文

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1. Li Y, Zheng H, Luo R, Wu H, Zhu H, Li R, Cao H, Wu B, Huang S, Shao H, Ma H,Zhang F, Feng S, Zhang W, Du H, Tian G, Li J, Zhang X, Li S, Bolund L,Kristiansen K, de Smith AJ, Blakemore AI, Coin LJ, Yang H, Wang J, Wang J. Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nature Biotechnology. 2011,29(8):723-730(SCI IF=31.1) 2. Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.Nature Biotechnology. 2011, 29(11):1019-23.(SCI IF=31.1) 3. Du H, Hu H, Meng Y, Zheng W, Ling F, Wang J, Zhang X, Nie Q, Wang X. The correlation coefficient of GC content of the genome-wide genes is positively correlated with animal evolutionary relationships. FEBS Letter. 2010, 584(18):3990-4(SCI IF=3.5) 4. Du HL, Chen J, Cui JX, Wang XN and Zhang XQ. Polymorphisms on SSC15q21-q26 containing QTL for reproduction in swine and its association with litter size. Genetics and Molecular Biology, 2009, 32(1):69-74(SCI) 5. Du HL, Chen J, Zhang YS, Zhang XQ. Molecular cloning, mapping, and polymorphism of the porcine SCG2 gene. Biochem Genet, 2008, 46 (3): 369-379.(SCI) 6. Du HL, Chen J, Cui JX, Zhang YS, Yerle M, Milan D, Zhang XQ. Radiation hybrid mapping and sequence analysis of 21 genes on porcine chromosome 15. Anim Genet, 2006, 37(2):181-183.(SCI IF=2.6) 7. Zeng QK, Du HL(并列第一), Wang JF, Wei DQ, Wang XN, Li YX, Lin Y. Reversal of Coenzyme Specificity and Improvement of Catalytic Efficiency of Pichia Stipitis Xylose Reductase by the Rational Site-directed Mutagenesis. Biotechnol Lett. 2009, 31(7):1025-9(SCI) 8. Fang M, Du H, Hu Y, Zhou X, Ouyang H, Zhang W, Jia X, Li J, Wang Y, Nie Q, Zhang X. Identification and Characterization of the Pig ABIN-1 Gene and Investigation of its Association with Reproduction Traits. J Genetic. 2011, 90(1):e10-20 9. Zhang YS, Du HL, Chen J, Yang GF, Zhang XQ. Porcine growth differentiation factor 9 gene polymorphisms and their associations with litter size. J Genet Genomics, 2008, 35 (3): 163-169.(SCI) 10. Cui JX, Du HL, Liang Y, Deng XM, Li N, Zhang XQ. Association of Polymorphisms in the Promoter Region of Chicken Prolactin with Egg Production.Poultry science. 2006, 85(1):26-31.(SCI Impact Factor=2.1) 11. Zhen FS, Du HL, Xu HP, Luo QB, Zhang XQ. Tissue and allelic-specific expression of hsp70 gene in chickens: basal and heat-stress-induced mRNA level quantified with real-time reverse transcriptase polymerase chain reaction. British Poultry science. 2006, 47(4):449-455.(SCI Impact Factor=1.3) 12. Jin X, He M, Ferguson B, Meng Y, Ouyang L, Ren J, Mailund T, Sun F, Sun L, Shen J, Zhuo M, Song L, Wang J, Ling F, Zhu Y, Hvilsom C, Siegismund H, Liu X, Gong Z, Ji F, Wang X, Liu B, Zhang Y, Hou J, Wang J, Zhao H, Wang Y, Fang X, Zhang G, Wang J, Zhang X, Schierup MH, Du H, Wang J, Wang X. An effort to use human-based exome capture methods to analyze chimpanzee and macaque exomes. PLoS One. 2012;7(7):e40637.通讯作者(SCI IF=4.0) 13. Chen J, Meng Y, Zhou J, Zhuo M, Ling F, Zhang Y, Du H, Wang X. Identifyingcandidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells. J Diabetes Res. 2013, 2013:970435. doi:10.1155/2013/970435.

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