凌飞 - 华南理工大学 - 生物科学与工程学院

个人简介

教育背景与研究经历： 1991-1995年，中山大学生命科学学院，动物学专业，学士学位 1999-2000年，华南师范大学生命科学院，进修生物化学与分子生物学研究生课程 2004、2008年，华南农业大学动物分子遗传专业，硕士、博士学位。 2008-2010年，华南理工大学生命科学与工程学院，博士后研究。 2013-2014年，美国华盛顿大学医学院基因组科学系，Josh Akey课题组，进化基因组研究。教学经历：主讲生物技术班《普通生物学》及《分子遗传学》这两门专业基础课和必修课。

研究领域

主要研究领域是动物分子遗传学、比较基因组与进化基因组学、免疫遗传学、表观遗传学，目前主要研究方向是：1）研究宿主多个限制性因子互作及其与逆转录病毒相互作用，建立灵长类动物SIV/HIV实验动物模型；2）利用生物信息学、进化基因组学方法，研究灵长类动物基因组调控区的变异、进化与重大疾病易感性等表型变异的关系。3）利用scRNA-seq和scDNase-seq等最新单细胞组学方法，研究：肿瘤免疫微环境单细胞组学；SIV感染中国恒河猴后重要免疫细胞在早期关键事件中的作用及其机制。

近期论文

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1、 uangmei Yan§, Guojie Zhang§, Xiaodong Fang§, Yanfeng Zhang§, Cai Li§, Fei Ling§, David N Cooper, Qiye Li, Yan Li, Alain J van Gool, Hongli Du, Jiesi Chen, Ronghua Chen, Pei Zhang, Zhiyong Huang, John R Thompson, Yuhuan Meng, Yinqi Bai, Jufang Wang, Min Zhuo, Tao Wang, Ying Huang, Liqiong Wei, Jianwen Li, Zhiwen Wang, Haofu Hu, Pengcheng Yang, Liang Le, Peter D Stenson, Bo Li, Xiaoming Liu, Edward V Ball, Na An, Quanfei Huang, Yong Zhang, Wei Fan, Xiuqing Zhang, Yingrui Li, Wen Wang, Michael G Katze, Bing Su, Rasmus Nielsen, Huanming Yang, Jun Wang, Xiaoning Wang* & Jian Wang*. Genome sequencing and comparison of two non-human primate animal models, cynomolgus monkey and the Chinese rhesus macaque. Nature Biotechnology, 2011, 29(11): 1019-1023 (co-first author) （§同等贡献） (if:43) 2、 He DD, Lu Y, Gittelman R, Jin Y, Ling F, Joshua A. Positive selection of the TRIM family regulatory region in primate genomes. Proc Biol Sci. 2016 Oct 12;283(1840). pii: 20161602 (通讯作者）二区，Top期刊(if:5.336) 3、 Su Z, Zhang J, Kumar C, Molony C, Lu H, Chen R, Stone DJ, Ling F, Liu X. Species-specific exome probes reveal new insights in positively selected genes in nonhuman primates. Sci Rep. 2016 Sep 23;6:33876. doi: 10.1038/srep33876. (共同通讯作者）二区(if:5.228) 4、 Hui-Ling Zhang , Feng-Liang Liu , Ya-Bin Jin, Qing Deng, Bei-Lei Liu, Min Zhuo, Xiao-Hui liu, Yong-Tang Zheng, Fei Ling. The effects of TRIM5α polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques. Virology, Volume 487, January 2016, Pages 222–229 (通讯作者）(if:3.2) 5、 W. Wang, D.-D. He, S.-L. Mao, M. Zhuo, F. Ling. Ten novel MHC class II alleles identified in cynomolgus macaques of Vietnamese origin. Tissue Antigens HLA. 2016 Feb;87(2):115-6. doi: 10.1111/tan.12731. Epub 2016 Jan 13 (通讯作者） 6、 Chen M, Song P, Zou D, Hu X, Zhao S, Gao S, Ling F. Comparison of multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC) in single-cell sequencing. PLoS One. 2014 Dec 8;9(12)(通讯作者) 7、 Wang W, Lu YE, Zhuo M, Ling F. Identification of five novel MHC class II alleles in cynomolgus macaques of Vietnamese origin. HLA. 2016 Jul;88(1-2):61-2. doi: 10.1111/tan.12840. Epub 2016 Jul 8(通讯作者) 8、 Liu B, Jin Y, Lu Y, Wu Y, Xue Y, Zhang Y, Liu Y, Zhuo M, Ling F. Comprehensive identification of high-frequency and combination MHC-DMA and -DMB alleles in a cohort of Chinese rhesus macaques and cynomolgus macaques of Vietnamese origin. Hum Immunol. 2015 Mar;76(2-3):109-12.(通讯作者) 9、 Zhang H, Deng Q, Jin Y, Liu B, Zhuo M, Ling F. Comprehensive identification of MHC class II alleles in a cohort of Chinese rhesus macaques. Immunogenetics. 2014 Oct; 66(9-10):575-80. doi: 10.1007/s00251-014-0789-y. Epub 2014 Jul 22 (通讯作者) 10、 Xiang R, Zhang H, Deng Q, Yue R, Tang H, Zhang Y, Ling F, Zhuo M, Du H, Xu S, Xu Q, Wang X. Comprehensive identification of high-frequency and co-occurring Mafa-DPA1, Mafa-DQA1, Mafa-DRA, and Mafa-DOA alleles in Vietnamese cynomolgus macaques. Immunogenetics. 2013 Sep;65(9):667-74. (通讯作者） 11、 Zhang G, Qiu W, Xiang R, Ling F, Zhuo M, Du H, Wang J, Wang X. TRIM5a Polymorphism Identification in Cynomolgus Macaques of Vietnamese Origin and Chinese Rhesus Macaques. Am J Primatol. 2013 Sep;75(9):938-46. (通讯作者） 12、 Qing Deng , Huiling Zhang , Ruirui Xiang, Zhenwu Zhang , Fei Ling, Min Zhuo & Hongli Du & Xiaoning Wang. Identification of Mamu-DPA1, -DQA1, and -DRA alleles in a cohort of Chinese rhesus macaques. Immunogenetics. 2013 65:901–904 (通讯作者） 13、 Fei Ling, Min Zhuo, Chao Ni, Gui-qing Zhang, Tao Wang, Li-qiong Wei, Hong-li Du, Ju-fang Wang, Xiao-ning Wang. Comprehensive identification of high-frequency and co-occurring Mafa-B, Mafa-DQB1 and Mafa-DRB alleles in cynomolgus macaques of Vietnamese origin. Hum Immunol. 2012 May;73(5):547-53. doi: 10.1016/j. 14、 Ling F, Wei LQ, Wang T, Wang HB, Zhuo M, Du HL, Wang JF, Wang XN. Characterization of the major histocompatibility complex class II DOB, DPB1, and DQB1 alleles in cynomolgus macaques of Vietnamese origin. Immunogenetics. (2011) 63:155–166. 15、 Ling F, Wang T, Wei L, Zhu X, Chen Y, Li J, Zhang Z, Du H, Wang X, Wang J. Cloning and characterization of the 5'-flanking region of the pig AgRP gene. Mol Biol Rep. 2011 Apr;38(4):2233-9. 16、 Ling F, Wei L, Wang T, Chen Y, Zhu X, Li J, Liu T, Du H, Wang H, Wang J. Cloning and Characterization of the 5'-Flanking Region of the Pig Cocaine- and Amphetamine-Regulated Transcript Gene. DNA Cell Biol. 2011 Feb;30(2):91-7. 17、 H.-B. Wang§, F. Ling§, M. Zhuo, J. –F Wang, X. -N Wang. Twenty-three novel MHC class I B alleles identified in cynomolgus macaques of Vietnamese origin. Tissue Antigen, 2011,77, 341–348 (co- first author) （§同等贡献） 18、 Ling F, Fang W, Chen Y, Li J, Liu X, Wang L, Zhang H, Chen S, Mei Y, Du H, Wang C. Identification of novel transcripts from the porcine MYL1 gene and initial characterization of its promoters . Mol Cell Biochem. 2010 Oct;343(1-2):239-47 19、 Fei Ling, Jiaqi Li, Yaosheng Chen, Hongli Du, Yingjie Mei, Delin Mo, Chong Wang. Cloning and characterization of the 5′-flanking region of the pig adiponectin gene. Biochemical and Biophysical Research Communications, 2009 Apr 3;381(2):236-40.