当前位置: X-MOL首页全球导师 国内导师 › 谢华锋

个人简介

2018-至今,华南理工大学特聘研究员,博士生导师 2014-2017,哈佛大学医学院,讲师 2006-2013,哈佛大学医学院,Dana-Farber癌症研究所,博士后 2006-2006,阿尔伯特-爱因斯坦医学院,博士后 2000-2005,阿尔伯特-爱因斯坦医学院,博士 1992-1996,武汉大学,理学学士

研究领域

以遗传学,分子生物学以及组学为主要研究方法, 研究表观遗传在干细胞自我复制,体细胞分化,细胞重编程以及白血病细胞中的调控 作用。 通过对相关表观遗传修饰及信号通路的干预,实现: 1)多能干细胞体外定向分化产生造血干细胞及血小板;2)造血干细胞体外扩增;3)增强细胞可塑性,促进细胞重编程。同时通过遗传学筛选寻找针对白血病干细胞的新的治疗靶点。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. H. Xie, C. Peng, J. Huang, B. E. Li, W. Kim, E. C. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P. P. Das, M. Nguyen, S. Li, J. E. Bradner, S. H. Orkin, Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer discovery 6, 1237-1247 (2016) 2. H. Xie, J. Xu, J. H. Hsu, M. Nguyen, Y. Fujiwara, C. Peng, S. H. Orkin, Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell stem cell 14, 68-80 (2014) 3. H. Xie, C. V. Laiosa, T. Graf, Reprogramming of committed lymphoid cells by enforced transcription factor expression. Methods in molecular biology 636, 219-232 4. H. Xie, S. H. Orkin, Immunology: changed destiny. Nature 449, 410-411 (2007) 5. H. Xie, M. Ye, R. Feng, T. Graf, Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676 (2004) 6. M. A. Erb, T. G. Scott, B. E. Li, H. Xie, J. Paulk, H. S. Seo, A. Souza, J. M. Roberts, S. Dastjerdi, D. L. Buckley, N. E. Sanjana, O. Shalem, B. Nabet, R. Zeid, N. K. Offei-Addo, S. Dhe-Paganon, F. Zhang, S. H. Orkin, G. E. Winter, J. E. Bradner, Transcription control by the ENL YEATS domain in acute leukaemia. Nature 543, 270-274 (2017) 7. S. Ai, Y. Peng, C. Li, F. Gu, X. Yu, Y. Yue, Q. Ma, J. Chen, Z. Lin, P. Zhou, H. Xie, T. W. Prendiville, W. Zheng, Y. Liu, S. H. Orkin, D. Z. Wang, J. Yu, W. T. Pu, A. He, EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. eLife 6,(2017) 8. M. Serresi, G. Gargiulo, N. Proost, B. Siteur, M. Cesaroni, M. Koppens, H. Xie, K. D. Sutherland, D. Hulsman, E. Citterio, S. Orkin, A. Berns, M. van Lohuizen, Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. Cancer cell 29, 17-31 (2016) 9. F. Mirzamohammadi, G. Papaioannou, J. B. Inloes, E. B. Rankin, H. Xie, E. Schipani, S. H. Orkin, T. Kobayashi, Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nature communications 7, 12047 (2016) 10. E. Danis, T. Yamauchi, K. Echanique, X. Zhang, J. N. Haladyna, S. S. Riedel, N. Zhu, H. Xie, S. H. Orkin, S. A. Armstrong, K. M. Bernt, T. Neff, Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell reports 14, 1953-1965 (2016) 11. J. Yin, J. W. Leavenworth, Y. Li, Q. Luo, H. Xie, X. Liu, S. Huang, H. Yan, Z. Fu, L. Y. Zhang, L. Zhang, J. Hao, X. Wu, X. Deng, C. W. Roberts, S. H. Orkin, H. Cantor, X. Wang, Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America 112, 15988-15993 (2015) 12. J. Xu, Z. Shao, D. Li, H. Xie, W. Kim, J. Huang, J. E. Taylor, L. Pinello, K. Glass, J. D. Jaffe, G. C. Yuan, S. H. Orkin, Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular cell 57, 304-316 (2015) 13. P. P. Das, D. A. Hendrix, E. Apostolou, A. H. Buchner, M. C. Canver, S. Beyaz, D. Ljuboja, R. Kuintzle, W. Kim, R. Karnik, Z. Shao, H. Xie, J. Xu, A. De Los Angeles, Y. Zhang, J. Choe, D. L. Jun, X. Shen, R. I. Gregory, G. Q. Daley, A. Meissner, M. Kellis, K. Hochedlinger, J. Kim, S. H. Orkin, PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell reports 12, 1456-1470 (2015) 14. T. Neff, A. U. Sinha, M. J. Kluk, N. Zhu, M. H. Khattab, L. Stein, H. Xie, S. H. Orkin, S. A. Armstrong, Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America 109, 5028-5033 (2012) 15. A. He, Q. Ma, J. Cao, A. von Gise, P. Zhou, H. Xie, B. Zhang, M. Hsing, D. C. Christodoulou, P. Cahan, G. Q. Daley, S. W. Kong, S. H. Orkin, C. E. Seidman, J. G. Seidman, W. T. Pu, Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation research 110, 406-415 (2012) 16. M. Yu, L. Riva, H. Xie, Y. Schindler, T. B. Moran, Y. Cheng, D. Yu, R. Hardison, M. J. Weiss, S. H. Orkin, B. E. Bernstein, E. Fraenkel, A. B. Cantor, Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular cell 36, 682-695 (2009) 17.R. Feng, S. C. Desbordes, H. Xie, E. S. Tillo, F. Pixley, E. R. Stanley, T. Graf, PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proceedings of the National Academy of Sciences of the United States of America 105, 6057-6062 (2008) 18. C. V. Laiosa, M. Stadtfeld, H. Xie, L. de Andres-Aguayo, T. Graf, Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 25, 731-744 (2006) 19. M. Ye, H. Iwasaki, C. V. Laiosa, M. Stadtfeld, H. Xie, S. Heck, B. Clausen, K. Akashi, T. Graf, Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19, 689-699 (2003)

推荐链接
down
wechat
bug