个人简介
2017-至今,华南理工大学教授,博士生导师 2015-2017,美国加州大学戴维斯分校副教授 2011-2015,美国加州大学戴维斯分校助理教授 2005-2010,美国加州大学戴维斯分校项目科学家、职员研究员 2000-2004,美国加州大学戴维斯分校博士后 1999-2000,美国康奈尔大学博士后 1991-1999,扬州大学副教授、讲师、助教 1994-1997,中国人民解放军农牧大学博士 1988-1988,扬州大学硕士 1984-1988,扬州大学学士
研究领域
干细胞再生医学及转化医学研究,干细胞肝脏细胞分化及分化机理研究,干细胞源肝脏细胞在生物医药的应用,肝脏损伤与再生;肿瘤干细胞分离、鉴定和形成机理及其在肿瘤发生发展中的作用研究,肿瘤治疗中肿瘤干细胞清除方法的研究。
近期论文
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1. Duan Y, J Wu,J Zhu, S Liu, I Ozaki, D Strayer, and MA Zern. Gene therapy for human alpha 1-Antitrypsin deficiency in an animal model using SV40-derived vectors. Gastroenterology2004; 127:1222-1232. 2. Duan Y, A Canata, Y Meng, N Yamamoto, S He, S Gupta, SS Gambhir and MA Zern. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. STEM CELLS 2007; 25:3058-3068. 3. Ma X, Y Duan, J Christine, J Wu, C VandeVoort, MA Zern. The differentiation of hepatocyte-like cells from monkey embryonic stem cells. Cloning and Stem Cells2008; 10:485-493. 4. Duan Y, X Ma, W Zou, C Wang, I Behbahan, T Ahuja, V Tolstikov, MA Zern. Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. STEM CELLS2010; 28:674-686. 5. Behbahan I, Y Duan, A Lam, S Khoobyari, X Ma, T Ahuja, M Zern. New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes. Stem cell Reviews and Reports2011; 7:748-59. 6. Ghaedi M, Soleimani M, Shabani I, Duan Y*, Lotfi A. Hepatic differentiation from human mesenchymal stem cells on a novel nanofiber scaffold. Cell Mol Biol Lett2012;17:89-106. 7. Ma X#, Y Duan#*, B Tschudy-Seney, G Roll, I Saramipoor Behbahan, T Ahuja, V Tolstikov, C Wang, J McGee, S Khoobyari, J Nolta, H Willenbring, MA Zern. Efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Translational Medicine 2013; 2:409-419. 8. Ghaedi M, Y Duan, MA Zern, A Revzin. Hepatic Differentiation of Embryonic Stem Cells on ECM Containing Growth Factors. J. Tissue Engineering and Regenerative Medicine 2014; 8(11):886-95. 9. Eun J, Y Jung, Y Zhang, Y Zhang, B Tschudy-Seney, R Ramsamooj, Y Wan, ND Theise, MA Zern, Y Duan*. Hepatoma SK Hep-1 cells exhibit characteristics of oncogenic mesenchymal stem cells with highly metastatic capacity. PLOS ONE 2014; 9:e110744. 10. Gao W, P Zhou, X Ma, B Tschudy-Seney, J Chen, Y Zhang, NL Magner, MA Zern, YDuan*. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway. PLOS ONE 2014; 9:e112698. 11. Park S, N Nguyen, J Eun, Y Zhang, Y Jung, B Tschudy-Seney, A Trotsyuk, A Lam, R Ramsamooj, Y Zhong, ND Theise, MA Zern, Y Duan*. Identification of Cancer Stem Cell Subpopulations of CD34+ PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas. Stem Cells and Development2015; 24(8):1008-21. 12. Park S, C Zeng, B Tschudy-Seney, N Nguyen, J Eun, Y Zhang, R Ramsamooj, Y Zhang, M Zhao, ND Theise, H Zhou, MA Zern, Y Duan*. Clonogenically culturing and expanding CD34+Liver cancer stem cells in vitro. Stem Cells and Development2015; 24(13):1506-14. 13.Zeng C, Y Zhang, S Park, J Eun J, N Nguyen, Y Jung, B Tschudy-Seney, ND Theise, MA Zern, Y Duan*. CD34+ Liver Cancer Stem Cells were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates. Stem Cells and Development 2015; 24(21):2467-78. 14.Chen J, Wei Gao W, Zhou P, Ma X, Tschudy-Seney B, Liu C, Zern MA, Liu P, Duan Y*. Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu. Sci Rep 2016; 6:18841. 15.Chen J, Chen L, Zern MA, Thesie ND, Diehl AM, Liu P, Duan Y*. The diversity and plasticity of adult hepatic progenitor cells and their niche. Liver International2017;37(9):1260-1271.