刘明 - 中国海洋大学

个人简介

2003年至2008年在中国海洋大学和丹麦Roskilde大学学习，获医学博士学位。2008年7月起，在中国科学院海洋研究所工作，方向为海洋活性物质的发现及作用机制的研究。2013年11月起，经中国海洋大学“青年英才工程”人才引进在中国海洋大学医药学院工作。近年来，针对肿瘤、代谢性疾病等疾病中重要的分子靶点或调控网络，以海洋天然产物为研究对象，开展了先导化合物的发现与功能研究；阐明这些活性物质的作用机制，探索新的药物靶点及调控网络，为新药研究提供物质基础和理论支持。2013年以来，申请人在Eur. J. Med. Chem. 等权威杂志上发表第一/通讯作者SCI论文23篇，第一发明人授权专利2项，应Springer与Wiley出版社邀请参编《Handbook of Anticancer Drugs from Marine Origin》与《Encyclopedia of Marine Biotechnology》英文专著2部；主持国家自然科学基金3项，山东省自然科学基金面上项目1项，青岛市应用基础研究专项1项；参与国家自然基金-山东省联合基金2项。

研究领域

1. 抗肿瘤化合物作用机制的研究 2. 化合物的活性筛选及成药性评价

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Wu, Guangwei(#); Qi, Xin(#); Mo, Xiaomei; Yu, Guihong; Wang, Qiang; Zhu, Tianjiao; Gu, Qianqun; Liu, Ming(*); Li, Jing(*); Li, Dehai(*), Structure-based discovery of cytotoxic dimeric tetrahydroxanthones as potential topoisomerase I inhibitors from a marine-derived fungus, European Journal of Medicinal Chemistry, 2018.2.13, 148: 268~278 2. Zhang, Weiyi(#); Che, Qian(#); Tan, Hongsheng; Qi, Xin; Li, Jing; Li, Dehai; Gu, Qianqun; Zhu, Tianjiao(*); Liu, Ming(*), Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin-proteasome system., Scientific Reports, 2017.2.8, 7: 42180~42180 3. Yuan, Fengli(#); Qiao, Liang; Chen, Yinghan; Qi, Xin; Liu, Yankai; Li, Dehai; Gu, Qianqun; Li, Jing(*); Liu, Ming(*), AS1041, a novel synthesized derivative of marine natural compound aspergiolide a, arrests cell cycle, induces apoptosis, and inhibits ERK activation in K562 cells, Marine Drugs, 2017.11, 15(11) 4. Liu, Ming(#)(*); Zhang, Weiyi; Zhang, Wei; Zhou, Xin; Li, Ming; Miao, Jinlai(*), Prenylflavonoid isoxanthohumol sensitizes MCF-7/ADR cells to doxorubicin cytotoxicity via acting as a substrate of ABCB1, Toxins, 2017.7, 9(7) 5. Liu, Ming(#)(*); Yin, Hua; Qian, Xiaokun; Dong, Jianjun; Qian, Zhonghua; Miao, Jinlai(*), Xanthohumol, a prenylated chalcone from hops, inhibits the viability and stemness of doxorubicin-resistant MCF-7/ADR cells, Molecules, 2017.1, 22(1) 6. Han, Fuguo; Wang, Peng; Zhang, Wei; Li, Jing; Zhang, Qun; Qi, Xin(*); Liu, Ming(*), CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization, Biom & Pharmacotherapy, 2016, 80: 151~161 7. Liu, Ming(#)(*); Chen, Fangling; Yu, Rilei; Zhang, Weiyi; Han, Mei; Liu, Fei; Wu, Jing; Zhao, Xingzeng; Miao, Jinlai(*), Synthesis and cytotoxicity against K562 cells of 3-O-Angeloyl-20-O-acetyl ingenol, a derivative of ingenol mebutate, International Journal of Molecular Sciences, 2016.8, 17(8) 8. Song, Xiaoping; Zhao, Zhimin; Qi, Xin; Tang, Shuai; Wang, Qiang; Zhu, Tianjiao; Gu, Qianqun; Liu, Ming(*); Li, Jing(*), Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90.,Oncotarget, 2015,6(7) :5263~5274 9. Qi, Xin; Liu, Ge; Qiu, Lin; Lin, Xiukun; Liu, Ming(*), Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems, Biomedicine & Pharmacotherapy,2015,75:58~66 10. Liu, Ge; Liu, Ming(*); Wei, Jianteng; Huang, Haijuan; Zhang, Yuyan; Zhao, Jin; Xiao, Lin; Wu, Ning; Zheng, Lanhong; Lin, Xiukun(*); CS5931, a novel polypeptide in ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs), Marine Drugs,2014,12(3) :1530~1544