杨金波 - 中国海洋大学

个人简介

山东省“泰山学者”特聘专家、中国海洋大学医药学院“筑峰”二层次教授、博士生导师；青岛海洋生物医药研究院首席科学家；青岛海洋科学与技术国家实验室海洋创新药物筛选与评价平台主任。兰州大学生物化学专业本科、中科院上海生物化学研究所生物化学与分子生物学博士。2001-2015年在美国克利夫兰医学中心学习、工作。2007年7月被聘为兰州大学“萃英特聘教授”、博士生导师，组建“兰州大学肿瘤生物学与药物研究所”并担任所长。2016年7月加入中国海洋大学医药学院、青岛海洋科学与技术国家实验室。

研究领域

研究方向为肿瘤生物学、肿瘤免疫学、抗肿瘤靶向药物高通量筛选与分子药理学，重点研究 JAK-STATs、NF-kB、EGF等信号转导关键分子的调控机制及其与肿瘤形成的关系、肿瘤耐药性关键分子的发现与分子机制、信号转导分子表观遗传学以及构建基于疾病靶点的高通量药物筛选与基于智能超算的药物虚拟筛选技术体系用于抗肿瘤、抗病毒、抗动脉粥样硬化药物的筛选及成药性研究。

近期论文

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1. Jing Nan, Yuxn Wang, Jinbo Yang* & George R. Stark*. IRF9 and unphosphorylated STAT2 cooperate with NF-kB to drive IL-6 expression. Proc Natl Acad Sci USA. (2018); 115(13). （影响因子9.67、一区） 2. Yuxin Wang, Jing Nan, Belinda Willard, Xin Wang, Jinbo Yang* & George R. Stark*. Negative regulation of type I interferon signaling by phosphorylation of STAT2 on T387. EMBO J. (2017); 36(2):202-212. （影响因子9.79，一区） 3. Jing Zhang#, Ning Zhu#, Yuping Du, Qifeng Bai, Xing Chen, Jing Nan, Xiaodong Qin, Xinxin Zhang, Jianwen Hou, Qin Wang & JinboYang*. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. (2015); 87(4):572-81. (#equal contribution) （影响因子4.128、二区） 4. Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang & Jinbo Yang*. TPCA-1 is a direct dual inhibitor of STAT3 and NFκB and regresses mutant EGFR associated human non-small cell lung cancers. Molecular Cancer Therapeutics. (2014); 13(3):617-29. (Selected for Cover Article of MCT) （影响因子5.68、二区） 5. Yuxin Wang, Anette H. H. van Boxel-Dezaire, HyeonJoo Cheon, Jinbo Yang* & George R. Stark*. STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor. Proc Natl Acad Sci USA. (2013); 110(42):16975-80.（影响因子9.67、一区） 6. Olga A. Guryanova, Qiulian Wu, Lin Cheng, Justin D. Lathia, Zhi Huang, Jinbo Yang, Jennifer MacSwords, Christine E. Eyler, Roger E. McLendon, John M. Heddleston, Weinian Shou, Dolores Hambardzumyan, Jeongwu Lee, Anita B. Hjelmeland, Andrew E. Sloan, Markus Bredel, George R. Stark, Jeremy N. Rich and Shideng Bao. Non-Receptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3. Cancer Cell. (2011); 19(4):498-511. （影响因子23.52、一区） 7. Jinbo Yang*, Jing Huang, Maupali Dasgupta, Nathan Sears, Masaru Miyagi, Benlian Wang, Mark R. Chance, Xing Chen, Yuping Du, Yuxin Wang, Lizhe An, Qin Wang, Tao Lu, Xiaodong Zhang, Zhenghe Wang and George R. Stark*. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A. (2010); 107(50):21499-504. （影响因子9.67、一区） 8. Jinbo Yang* & George R. Stark*. Roles of Unphosphorylated STATs in Signaling. Cell Research. (2008); 18(4): 443-451. （影响因子15.61、一区） 9. Jinbo Yang, Xudong Liao, Mukesh K. Agarwal, Laura Barnes, Philip E. Auron and George R. Stark. Unphosphorylated STAT3, Increased by gp130-Linked Cytokines, Activates Transcription by Binding to NFkB. Genes & Development. (2007); 21(11):1396-408. （影响因子10.80、一区） 10. Jinbo Yang, Moitreyee Chatterjee-Kishore, Susan M. Staugaitis, Hannah Nguyen, Karni Schlessinger, David E. Levy and George R. Stark. Novel Roles of Unphosphorylated STAT3 in Oncogenesis and Transcriptional Regulation. Cancer Research. (2005); 65: (3):939-47. （影响因子9.12、一区） 11. Li YANG, Jin Bo YANG, Jia CHEN, Guang Yao YU, Pei ZHOU, Lei LEI, Zhen Zhen WANG, Catherine CY CHANG, XinYing YANG, Ta Yuan CHANG, Bo Liang LI. Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. Cell Research. (2004); 14(4): 315-23. （影响因子15.61、一区） 12. Jun Zhang, Jinbo Yang, Sanjit K. Roy, Silvia Tininini, Jiadi Hu, Jacqueline F. Bromberg, Valeria Poli, George R. Stark, and Dhananjaya V. Kalvakolanu. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A. (2003); 100(16):9342-7. （影响因子9.67、一区） 13. Jin-Bo Yang, Zhi-Jun Duan, Wei Yao, Onel Lee, Li Yang, Xin-Ying Yang, Xia Sun, Catherine C.Y. Chang, Ta-Yuan Chang and Bo-Liang Li. Synergistic transcriptional activation of human ACAT-1 gene by IFN-g and ATRA in THP-1 cells. J. Biol. Chem. (2001); 276 (24):20989-98. （影响因子4.13、二区）