杨金波 - 中国海洋大学

个人简介

教育背景： 1987.09 - 1991.06，兰州大学，生物化学专业，学士 1996.09 - 2001.06，中国科学院上海生物化学与细胞生物学研究所，生物化学与分子生物学，博士工作经历： 2007.07 - 2016.06，兰州大学生命科学学院，“萃英” 特聘教授、博士生导师 2007.07 - 2016.06，兰州大学肿瘤生物学与药物研究所，所长 2016.07 - 至今，中国海洋大学医药学院，教授、博士生导师 2016.07 - 2022.04，青岛海洋生物医药研究院，PI、首席科学家 2016.09 - 至今，青岛海洋科学与技术国家实验室海洋创新药物筛选与评价平台，主任 2022.05 - ，中国海洋大学海洋生物医药研究院，“蓝药人才” 首席教授获奖荣誉： “基于 NFκB 为靶点的抗肿瘤先导化合物的高通量筛选体系建立及应用”，甘肃省科技进步二等奖（2/9，2010） “基于 NFκB 为靶点的抗肿瘤先导化合物的高通量筛选体系的建立和药理研究”，甘肃省教育厅高校科技进步一等奖（2/16，2010） “针对靶点细胞模型的建立以及在药物筛选中的应用” ，甘肃省科技进步二等奖（2/7，2014） 2008 年教育部 “新世纪人才” 2016 年青岛市 “创新领军人才” 2017 年青岛海洋科学与技术国家实验室 “鳌山人才” 卓越科学家 2017 年山东省 “泰山学者” 特聘专家

研究领域

肿瘤生物学、肿瘤免疫学、分子药理学。肿瘤信号转导网络调控关系与机制、肿瘤免疫微环境与组学研究、信号转导分子的表观遗传学。基于疾病靶点的药物高通量筛选及基于智能超算的药物虚拟筛选技术体系用于抗肿瘤药物的筛选及成药性研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Qiaoling Song, Shyamasree Datta, Xue Liang, Xiaohan Xu, Paul Pavici, Xiaonan Zhang, Yuanyuan Zhao, Shan Liu, Zhan Zhao, Chunhua Lin, Yuxin Wang, Peng Han, Peng Jiang, Yating Qin, Wei Li, Yingying Zhang, Yonglun Luo, Ganes Sen, George R. Stark, Chenyang Zhao*, Thomas Hamilton*&Jinbo Yang*. Type I Interferon Signaling Facilitates Resolution of Acute Liver Injury by Priming Macrophage Polarization. Cellular & Molecular Immunology. (2023); 20(2):143-157. (IF 22.1) Ruihua Liu, Yang Tian, Jie Wang, Zemin Wang, Xiangqian Li, Chenyang Zhao, Ruoyu Yao, Shuo Li, Leifeng Yuan, Jinbo Yang*&Dayong Shi*. Visible-light-initiated radical 1,3-difunctionalization of β,γ-unsaturated ketones. Science Advances. (2022); 8(49):eabq8596. (IF 15.0) Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin & Jinbo Yang*. Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Signal Transduction and Targeted Therapy. (2022); 7(1):287. (IF 38.1) Wei Wei, Yazhuo Zhang, Qiaoling Song, Qianyue Zhang, Xiaonan Zhang, Xinning Liu, Zhihua Wu, Xiaohan Xu, Yuting Xu, Yu Yan, Chenyang Zhao* & Jinbo Yang*. Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment. Cellular and Molecular Life Sciences. (2022); 79(8):403. (IF 9.3) Zhan Zhao, Yazhuo Zhang, Danling Gao, Yidan Zhang, Wenwei Han, Ximing Xu, Qiaoling Song, Chenyang Zhao* & Jinbo Yang*. Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages. Front Immunol. (2022); 13:818070. (IF 8.8) Yuxin Wang, Qiaoling Song, Wei Huang, Yuxi Lin, Xin Wang, Chenyao Wang, Belinda Willard, Chenyang Zhao, Jing Nan, Elise Holvey-Bates, Zhuoya Wang, Derek Taylor, Jinbo Yang* & George R. Stark*. A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses. Cell Research. (2021); 31(2):206-218. (IF 25.6) Han Wang#, Hao Zhou#, Quanri Zhang, Kyle L. Poulsen, Vanessa Taylor, Megan R. McMullen, Doug Czarnecki, DhweejaDasarathy, Minjia Yu, Yun Liao, Daniela S. Allende, Xing Chen, Lingzi Hong, Junjie Zhao, Jinbo Yang*, Laura E. Nagy* & Xiaoxia Li*. Inhibition of IRAK4 kinase activity improves ethanol induced liver injury in mice. J. Hepatology. (2020); 73(6):1470-1481. (IF 25.1) Ning Zhu, Jing Zhang, Yuping Du, Xiaodong Qin, Ruidong Miao, Jing Nan, Xing Chen, Jingjie Sun, Rui Zhao, Xinxin Zhang, Lei Shi, Xin Li, Yuxi Lin, Wei Wei, Aihong Mao, Zhao Zhang, George R. Stark*, Yuxin Wang* & Jinbo Yang*. Loss of ZIP Facilitates JAK2-STAT3 Activation in Tamoxifen-Resistant. Proc Natl Acad Sci USA. (2020); 117(26):15047-15054. (IF 11.2) Jing Nan, Yuxn Wang, Jinbo Yang* & George R. Stark*. IRF9 and unphosphorylated STAT2 cooperate with NF-kB to drive IL-6 expression. Proc Natl Acad Sci USA. (2018); 115(15):3906-3911. (IF 9.4) Yuxin Wang, Jing Nan, Belinda Willard, Xin Wang, Jinbo Yang* & George R. Stark*. Negative regulation of type I interferon signaling by phosphorylation of STAT2 on T387. EMBO J. (2017); 36(2):202-212. (IF 11.2) Yuxin Wang, Anette H. H. van Boxel-Dezaire, HyeonJooCheon, Jinbo Yang*& George R. Stark*. STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor. Proc Natl Acad Sci USA. (2013); 110(42):16975-80. (IF 9.8) Jinbo Yang*, Jing Huang, Maupali Dasgupta, Nathan Sears, Masaru Miyagi, Benlian Wang, Mark R. Chance, Xing Chen, Yuping Du, Yuxin Wang, Lizhe An, Qin Wang, Tao Lu, Xiaodong Zhang, Zhenghe Wang & George R. Stark*. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A. (2010); 107(50):21499-504. (IF 9.8) Jinbo Yang, Xudong Liao, Mukesh K. Agarwal, Laura Barnes, Philip E. Auron& George R. Stark*. Unphosphorylated STAT3, Increased by gp130-Linked Cytokines, Activates Transcription by Binding to NFB. Genes & Development. (2007); 21(11):1396-408. (IF 14.8) Jinbo Yang, Moitreyee Chatterjee-Kishore, Susan M. Staugaitis, Hannah Nguyen, Karni Schlessinger, David E. Levy & George R. Stark*. Novel Roles of Unphosphorylated STAT3 in Oncogenesis and Transcriptional Regulation. Cancer Research.(2005); 65: (3):939-47. (IF 7.6) Jin-Bo Yang, Zhi-Jun Duan, Wei Yao, Onel Lee, Li Yang, Xin-Ying Yang, Xia Sun, Catherine C.Y. Chang, Ta-Yuan Chang & Bo-Liang Li*. Synergistic transcriptional activation of human ACAT-1 gene by IFN- and ATRA in THP-1 cells. J. Biol. Chem. (2001); 276 (24):20989-98. (IF 7.3)