王成 - 中国海洋大学

个人简介

王成博士, 副教授。主要从事生物医用纳米载体材料的构建与靶向给药系统的研究。以第一负责人主持国家自然科学面上基金、国家自然科学青年基金、中国博士后科学基金、博后特别资助基金、山东省自然基金、青岛市应用基础研究专项、中国海洋大学青年教师基金等多项，以第三负责人完成国家重大新药创制2项，并于2015年9月借调国家食品药品监督管理总局药品审评中心挂职工作一年，兼任山东省一致性评价技术专家委员会药物制剂组专家、青岛市中级人民法院知识产权技术咨询专家，中国生物物理学会会员，中国医药生物技术协会纳米生物技术委员会委员，青岛市药剂学会副主任委员。主持完成20多个新药立项与申报。在Nat Med, J Control Release, J Biomed Nanotechnol, Nanoscale, Curr Drug Metab, Int J Pharm等国际纳米载体及传输领域期刊上发表SCI论文20多篇；申报中国发明专利15项。应邀为J Biomed Nanotechnol, Int J Pharm, Colloid and Surface B, J Nanosci Nanotechnol等国际杂志审稿四十余篇次。

研究领域

（1）靶向给药系统的研究（2）生物医用纳米载体材料的构建（3）应用药物制剂的研究与开发

近期论文

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1.MianYu, MiaoqingZhao, RileiYu,ShaochenChua, JiahaoXu, MingXia, Cheng Wang*. Nanotechnology-mediated immunochemotherapy with Ingenol-3-Mebutate for Systematic Anti-tumor Effects. J Control Release. 304, 242-258,2019 (1区，Top，IF=7.901) 2. Jiaqi Yin，Weijian Wang，Xuelian Xu，Hongxia Li，Mengyi Cong，Xia Zhao* and Cheng Wang* Preparation, characterization and pharmacokinetics of extended-release tablets of of marine polysaccharide drug. J Drug Deliv Sci Tec. 43, 353-361, 2018 3. Ying hao, Jinrong Peng, Yaguang Zhang, Lijuan Chen, Feng Luo, Cheng Wang* and Zhiyong Qian*. Tumor Neovasculature-Targeted APRPG-PEG-PDLLA/MPEG- PDLLA Mixed Micelle Loading CombretastatinA‑4 for Breast Cancer Therapy.ACS Biomater Sci Eng.4, 1986-1999，2018. 4. Hongxia Li, Yun Li, Xuelian Xu, Mengyi Cong, Jiaqi Yin and Cheng Wang*. Preparation and Characterization of Novel Pimecrolimus Nanoparticles for Therapy of Allergic Conjunctivitis. J Biomed Nanotechnol.13,1106-1114 2017. 5.Mengyi Cong,Zhongyu Wu,Xuelian Xu,Jiaqi Yin, Hongxia Li, Bo Zhuang, Cheng Wang* and Xia Zhao*. Novel Oleyl Amine-modified Polymannuronic Acid Micelle Loading Tacrolimus for Therapy of Allergic Conjunctivitis.Int J BiolMacromol. 104,862-873 2017. 6.Cheng Wang1*, Biao Liu2+, Xuelian Xu1, Bo Zhuang1, Hongxia Li1, Jiaqi Yin1, Mengyi Cong1, Wei Xu3,4 and Aiping Lu2*Toward Targeted Therapy in Chemotherapy-resistant Pancreatic Cancer with A Smart Triptolide Nanomedicine.Oncotarget. 7(7). 8360-72 2016 7.Bo Zhuang, Liang Du, Hongxia Xu, Xuelian Xu,Cheng Wang*, Yingfang Fan, Mengyi Cong, Jiaqi Yin, Hongxia Li and Huashi Guan*. Self-assembled Micelle Loading Cabazitaxel for therapy of Lung Cancer. Int J Pharm. 499:146-155.2016. 8.Yingfang Fan, Bo Zhuanga, Cheng Wang*, Xuelian Xu, Wei Xu, Zhihua Lv*. Pimecrolimus micelle exhibits excellent therapeutic effect for Keratoconjunctivitis Sicca. Colloid and Surface B. 140 1-10. 2016. 9. Cheng Wang*, Ying Shan, Jiuli Yang, Xuelian Xu, Bo Zhuang, Yingfang Fan and Wei Xu*. Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles . J Biomed Nanotechnol. 11. 805-815 2015. 10.Chao Liang#, Baosheng Guo#, Heng Wu#, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, etc. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 21(3):288-94,2015.