个人简介
教育背景:
2000.09~2005.07 中科院上海有机化学研究所 有机化学 博士
1994.09~1998.06 兰州大学 放射化学 学士
工作经历:
2016.1~今 中国海洋大学 医药学院 教授
2011.07~2015.12 天津大学 药物科学与技术学院 副教授
2009.05~2011.06 中科院青岛生物能源与过程研究所 副研究员
2006.01~2009.03 美国威斯康辛大学麦迪逊分校 药学院 博士后
2005.08~2005.12 美国明尼苏达大学 化学系 博士后
1998.07~2000.07 成都地奥集团 工程师
项目课题:
1. 国家自然科学基金面上项目,21772181,一些海洋吲哚生物碱的合成与其生物靶点确认研究,2018/01-2021/12,在研,主持
2. 国家自然科学基金面上项目,21172169,Aplykurodinone-1和 (-)-Actinophyllic acid的全合成研究,2012/01-2015/12,结题,主持
3. 国家自然科学基金面上项目,21572154,酚参与的oxa-[3+3]环加成反应在天然产物全合成中的应用研究,2016/01-2019/12,在研,参与
4.中国海洋大学英才计划“第一层次”科研基金(2016-2021)在研,主持
5.山东省重点研发计划,2018GSF118022,来自海洋的抗病毒药物研发,2017/10-2019/10,在研,主持
承担课程:
海洋药物前沿讲座(本科生课程)
药物化学前沿(博士课程)
研究领域
开发出了一个仿生合成杂环化合物的[3+3]环合反应,即vinylogous amides或二酮类化合物与不饱和亚胺盐的环加成反应。运用该反应,成功合成了一系列复杂天然产物,包括(±)-Trichodermatides B and C,Cannabicyclol, Clusiacyclol A and B, Iso-Eriobrucinol A and B, and Eriobrucinol., Paraensidimerines。
近期论文
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Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting β-tubulin
Fang Shiyuan,Bi Shijie,Li Yannan,Tian Shuai,Xu Huixin,fu Lei,Wang Shixiao,Tang Yu,Qiu Peiju
Page:129370 ISSN:0960-894X 2023
Container-title:Bioorganic & Medicinal Chemistry Letters
Bio-inspired formal total synthesis of (±)-bisabosqual A
Du Xuanxuan,Liu Hainan,Wu Yumeng,Tang Yu
Page:1042-1046 ISSN:2052-4129 2023
Container-title:Organic Chemistry Frontiers
Bio-inspired construction of a tetracyclic ring system with an avarane skeleton: total synthesis of dactyloquinone A
Organic Chemistry Frontiers
2022 | Journal article
DOI: 10.1039/D2QO00792D
CONTRIBUTORS: Yumeng Wu; Xuanxuan Du; Xianyang Wang; Hainan Liu; Luning Zhou; Yu Tang; Dehai Li
Total Synthesis of Leptochartamides A and B: Two Enantiomeric Pairs of Hydroxybenzyl Dimers from a Deep-Sea Fungus Leptosphaerulina chartarum
The Journal of Organic Chemistry
2022-08-19 | Journal article
DOI: 10.1021/acs.joc.2c01347
CONTRIBUTORS: Meimei Cheng; Xuechao Cui; Yu Tang; Zongze Shao; Xiupian Liu; Juncheng Su; Jian Zhang; Qi Wang; Guoqiang Li
Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections
Wang Zhenhao,Zang Ruochen,Niu Zhao,Wang Wei,Wang Xin,Tang Yu
Page:128405 ISSN:0960-894X 2021
Container-title:Bioorganic & Medicinal Chemistry Letters
Catalyst-Free [4+2] Cycloaddition of Ynamides with 2-Halomethyl Phenols To Construct 2-Amino-4H-Chromenes and α-Halo Enamides Simultaneously
Hao Wen, Weibo Yan, Ping Chen*, Yu Li, and Yu Tang*
Cite this: J. Org. Chem. 2020, 85, 20, 12870–12881
Publication Date:October 1, 2020
https://doi.org/10.1021/acs.joc.0c01258
Total syntheses of (+)-arisugacins F, G
Chen Ping,Wu Hao,Li Yu,Tang Yu
Page:152172 ISSN:0040-4039 2020
Container-title:Tetrahedron Letters
Total Synthesis of Isohericenone J via a Stille Coupling Reaction
Wei Cao, Ping Chen, and Yu Tang*
Cite this: J. Nat. Prod. 2020, 83, 5, 1701–1705
Publication Date:April 30, 2020
https://doi.org/10.1021/acs.jnatprod.9b01251
Application of E1cB Elimination in Asymmetric Organocatalytic Cascade Reactions To Construct Polyheterocyclic Compounds
Organic Letters
2019-10-18 | Journal article
DOI: 10.1021/acs.orglett.9b03138
CONTRIBUTORS: Zhi-Hao You; Ying-Han Chen; Yu Tang; Yan-Kai Liu
Preparation of isoquinazolines via metal-free [4 + 2] cycloaddition of ynamides with nitriles
Wu Hao,Liu Yu,He Ming-xing,Wen Hao,Cao Wei,Chen Ping,Tang Yu
Page:8408-8416 ISSN:1477-0520 2019
Container-title:Organic & Biomolecular Chemistry
Organocatalytic Asymmetric Synthesis of Spiro-Bridged and Spiro-Fused Heterocyclic Compounds Containing Chromane, Indole, and Oxindole Moieties
Organic Letters
2018-11-02 | Journal article
DOI: 10.1021/acs.orglett.8b02731
CONTRIBUTORS: Zhi-Hao You; Ying-Han Chen; Yu Tang; Yan-Kai Liu