江涛 - 中国海洋大学

个人简介

江涛，女，博士，教授，博士生导师；教育部优秀青年奖励计划的获得者，《精细化工》杂志编委，E. J. Med. Chem, Bioorg. Med. Chem., Tetrahedron等杂志审稿人。 1988-1993中国科学院长春应用化学研究所博士学位，1993-1995香港浸会大学博士后研究，1996年英国University of Essex 访问学者。1997年至今中国海洋大学医药学院和海洋药物与食品研究所工作，其中2004年11-12月在加拿大McGill 大学进行合作研究。1997年12月晋升教授，2001年聘为博士生导师。近年来设计合成了一些列核酸插入试剂和剪切试剂；完成了多种海洋天然产物海洋生物碱杂多环的合成及其结构优化与构效关系研究；进行了基于糖结构的药物设计与合成及生物活性研究；多个化合物进入候选药物或系统临床前研究阶段。共主持、承担23项科研项目，项目转让4项；目前在研课题科技部国际合作项目1项、国家自然科学基金项目2项及其他项目,到位总经费400余万元。在Chem. Comm., J. Med. Chem, E. J. Med. Chem., Bioorg. Med. Chem等发表研究论文80余篇；申请国家发明专利12余项，授权6项。

研究领域

1. 海洋天然产物如海洋生物碱杂多环的合成及其结构优化与构效关系研究；2. 活性分子的糖基化、磷酸酯化等化学修饰和基于糖结构的药物设计与合成。

近期论文

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Aglycone Ebselen and β-D-Xyloside Primed Glycosaminoglycans Co-contribute to Ebselen-β-d-Xyloside-Induced Cytotoxicity, Yang Tang, Siqi Zhang, Yajing Chang, Dacheng Fan, Ariane De Agostini, Lijuan Zhang*, and Tao Jiang*, J. Med. Chem., 2018, 61 (7), 2937-2948, Wei Wang, Ruijuan Yin, Meng Zhang, Rilei Yu, Cui Hao, Lijuan Zhang*, and Tao Jiang*,Boronic Acid Modifications Enhance the Anti-Influenza A Virus Activities of Novel Quindoline Derivatives, J. Med. Chem., 2017, 60 (7), pp 2840–2852 Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90, Long Jiang, Ruijuan Yin, Xueting Wang, Jiajia Dai, Jing Li, Tao Jiang*, Rilei Yu*, Euro. J. Med. Chem., 2017, 135, 24-33 Isothiouronium modification empowers pyrimidine-substituted curcumin analogs potent cytotoxicity and Golgi localization, Sheng Tong; Meng Zhang; Shixi Wang; Ruijuan Yin; Rilei Yu; Shengbiao Wan; Tao Jiang *; Lijuan Zhang *, Eur. J. Med. Chem. (2016), 123, 849-857 Pharmacokinetics in vitro and in vivo of two novel prodrugs of oleanolic acid in rats and its hepatoprotective effects against liver injury induced by CCl4, Zongjiang Yua, , Weizhi Sun, Weibing Peng, GuoqiangLi,Tao Jiang*, Molecular Pharmaceutics (2016), 13(5), 1699-1710. Design, Synthesis, and Biological Evaluation of NovelNon-Covalent Binding Quinazoline Glycoside Derivatives Targeting the Epidermal Growth Factor Receptor (EGFR) KinaseT790M/L858R Mutant, Renshuai Zhang, Shaopeng Chen, Xiaowei Zhang, Jing Ai, Shengbiao Wan, Meiyu Geng2*, Tao Jiang1*, RSC Advances, (2016), 6(43), 36857-36862. Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1), Jiachi Chiou, Shengbiao Wan, Kin-Fai Chan, Pui-Kin So, Dandan He, Edward Wai-chi Chan, Tak-hang Chan, Kwok-yin Wong, Jiang Tao* and Sheng Chen*, Chem. Commun., 2015,51, 9543-9546 Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells, Ruijuan Yin, Meng Zhang, Cui Hao, Wei Wang, Peiju Qiu, Shengbiao Wan, Lijuan Zhang* and Tao Jiang*, ChemComm, (2013)