李延团 - 中国海洋大学

个人简介

教育背景： 1978.02 - 1982.02，曲阜师范大学，化学，学士 1999.09 - 2002.06，四川大学，物理化学，博士工作经历： 1982.02 - 1989.11，曲阜师范大学化学与化工学院，助教 1989.12 - 1994.11，曲阜师范大学化学与化工学院，讲师 1994.12 - 1995.11，曲阜师范大学化学与化工学院，副教授 1995.12 - 2002.06，曲阜师范大学化学与化工学院，教授 2002.07 - 至今，中国海洋大学医药学院，教授获奖荣誉： 1998 年，获 “国家教育部科技进步三等奖” 1999 年，获 “山东省科技进步二等奖” 2000 年，获 “山东省科技进步三等奖” 2001 年，获 “山东省科技进步三等奖” 2001 年，获 “山东省高校优秀成果一等奖” 2001 年，获 “全国五一劳动奖章” 称号 2001 年，获 “山东省优秀青年知识分子标兵提名奖” 和 “山东省优秀青年知识分子” 称号 2001 年，获 “山东省高校十大优秀教师” 称号 2004 年，获 “青岛专业技术拔尖人才” 称号 2009 年，获 “青岛专业技术拔尖人才” 称号 2009 年，获 “山东省高等教育教学成果一等奖” 2010 年，获 “山东省优秀博士论文指导教师” 称号 2013 年，获 “山东省优秀博士论文指导教师” 称号 2015 年，获 “山东省优秀研究生指导教师” 称号

研究领域

新型药物共晶的设计与成药性评价研究药物共晶制备关键技术研究优势药物晶型筛选与质量控制研究基于生物大分子相互作用的抗肿瘤药物设计与合成

近期论文

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代表性论文 1. Kang Zheng, Mei-Xing Yan, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Synthesis and structure of new dicopper(II) complexes bridged by N-(2-hydroxy-5-methylphenyl)-N′-[3-(dimethylamino)propyl]oxamide with in vitro anticancer activity: A comparative study of reactivities towards DNA/protein by molecular docking and experimental assays. European Journal of Medicinal Chemistry, 2016, 109: 47-58. 2. Fang Liu, Yu Song, Ya-Nan Liu, Yan-Tuan Li*, Zhi-Yong Wu*, Cui-Wei Yan. Drug-bridge-drug ternary cocrystallization strategy for antituberculosis drugs combination. Crystal Growth & Design, 2018, 18(3): 1283-1286. 3.Fang Liu, Ling-Yang Wang, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Protective effects of quercetin against pyrazinamide induced hepatotoxicity via a cocrystallizationstrategy of complementary advantages. Crystal Growth & Design, 2018, 18(7): 3729-3733. 4. Yu Song, Ling-Yang Wang, Fang Liu, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Simultaneously enhancing the in vitro/in vivo performances of acetazolamide using proline as a zwitterionic coformer for cocrystallization. CrystEngComm, 2019, 21(19): 3064-3073. 5. Kang Zheng, Liu Jiang, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Synthesis and structure of new dicopper(II) complexes bridged by asymmetric N,N′-bis(substituted)oxamides:In vitro anticancer activity and molecular docking studies based on bio-macromolecular interaction. RSC Advances, 2015, 5(64): 51730-51744. 6. Ling-Yang Wang, Kang Zheng, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Synthesis, structure and in vitro antiproliferative activities of oxamido-bridged dicopper(II) complexes: A comparative study of experimental evidence and molecular docking of DNA/protein binding. Applied Organometallic Chemistry, 2018, 32(1): e3940. 7. Kang Zheng, Fang Liu, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan.Synthesis and structure elucidation of new μ-oxamido-bridged dicopper(II) complexes showing in vitro anticancer activity: Evaluation of DNA/protein-binding properties by experiment and molecular docking. Journal of Inorganic Biochemistry, 2016, 156: 75-88. 8. Ling Zhu, Kang Zheng, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Synthesis and structure elucidation of new μ-oxamido-bridged dicopper(II) complex with in vitro anticancer activity: A combined study from experiment verification and docking calculation on DNA/protein-binding property. Journal of Photochemistry and Photobiology B: Biology, 2016, 155: 86-97. 9.Ya-Xuan Zhang, Ling-Yang Wang, Jin-Kai Dai, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. The comparative study of cocrystal/salt in simultaneously improving solubility and permeability of acetazolamide. Journal of Molecular Structure, 2019, 1184: 225-232. 10. Mei-Jiao Zhang, Fang Liu, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan. Synthesis, structure, and biological active evaluation of a new cyclic tetranuclearcopper(II) complex bridged both by oxamido and carboxylate groups. Journal of Biochemical and Molecular Toxicology, 2018, 32(1): e22003.