卢玲 - 中国海洋大学

个人简介

2006年毕业于第二军医大学药理专业获博士学位。2006年至今在中国海洋大学医药学院工作。2011年至2012年于美国密歇过大学分子细胞发育生物学系进行为期一年的访问学者研究。主讲《人体解剖生理学》等课程。主要从事缺氧信号转导通路相关分子在肿瘤发生发展和胚胎发育的作用及机理研究。结合胰岛素样生长因子系统，已发现多个缺氧诱导因子（HIF）的靶基因。主持完成国家自然基金面上项目1项，参与国家973、国家自然科学基金、教育部培育项目多项。发表研究论文10余篇。

研究领域

1.缺氧应激反应的分子调控 2.缺氧信号通路分子在斑马鱼早期胚胎发育中的作用机理 3.斑马鱼缺氧诱导因子HIF活性调控模型的建立

近期论文

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1. Zhang C, Lu L*, Li Y, Wang X, Zhou J, Liu Y, Fu P, Gallicchio MA, Bach LA, Duan C*. IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Int J Cancer. 2012 ;130(9):2003-12 2. Jiao S, Ren H, Li Y, Zhou J, Duan C, Lu L*. Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells. Mol Cell Biochem. 2013 Jan; 373(1-2):107-13. doi: 10.1007/s11010-012-1479-4. Epub 2012 Oct 10 3. Lu L, Yang PY, Rui YC, Zhang J, Kang H. Comparative proteome analysis of rat brain and coronary microvascular endothelial cells. Physiol Res. 2007; 56(2):159-68 4. Zhang P, Lu L, Yao Q, Li Y, Zhou J, Liu Y, Duan C. Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible actor-3α.Am J Physiol Regul Integr Comp Physiol. 2012; 303(11):R1165-74 5. Zhong Y, Lu L, Zhou J, Li Y, Liu Y, Clemmons DR, Duan C.IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. J Cell Sci. 2011;124(Pt 11):1925-35 6. Jiao S, Dai W, Lu L, Liu Y, Zhou J, Li Y, Korzh V, Duan C.The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish. Endocrinology.2011; 152(5):1860-71 7. Feng Q, Zou X, Lu L, Li Y, Liu Y, Zhou J, Duan C.The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/β-catenin Activity in Zebrafish.PLoS One. 2012;7(12):e52674. 8. Liu S, Yang P, Kang H, Lu L, Zhang Y, Pan J, Rui YC. NDRG2 induced by oxidized LDL in macrophages antagonizes growth factor productions via selectively inhibiting ERK activation.Biochim Biophys Acta.2010; 1801(2):106-13 9. Li M, Li Y, Lu L, Wang X, Gong Q, Duan C. Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol.2009 Mar;296(3):R558-66 10. Wang X, Lu L, Li Y, Li M, Chen C, Feng Q, Zhang C, Duan C. Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am J Physiol Regul Integr Comp Physiol.2009 May; 296(5):R1348-57 11. Kamei H, Lu L, Jiao S, Li Y, Gyrup C, Laursen LS, Oxvig C, Zhou J, Duan C. Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish. PLoS ONE.2008 Aug 28;3(8):e3091 12. Lu L, Yang PY, Rui YC, Zhang J, Kang H. Comparative proteome analysis of rat brain and coronary microvascular endothelial cells. Physiol Res. 2007; 56(2):159-68