李国云 - 中国海洋大学

个人简介

教育背景： 2005.09 - 2009.06，中国海洋大学，食品科学与工程，学士 2009.09 - 2015.06，中国海洋大学，水产品加工与贮藏工程，博士 2012.09 - 2014.09，美国伦斯勒理工学院，糖分析化学，联合培养博士工作经历： 2015.07 - 2018.01，中国海洋大学医药学院，博士后 2015.07 - 2020.11，中国海洋大学医药学院，副教授 2020.12 - 至今，中国海洋大学医药学院，教授获奖荣誉： 2019 年，山东省科技进步奖二等奖（第 2 位） 2023 年，中国产学研合作创新（个人）奖 2023 年，青岛市科技成果转化贡献奖（第 12 位） 2022 年，山东青年创新突击队 - “蓝色药库” 开发青年创新团队 2024 年，泰山学者青年专家

研究领域

海洋糖类药源分子的发现与鉴定、构效关系与作用机制研究糖分析新方法在糖类药物质量控制和药代动力学研究中的应用内源性糖链精细结构分析和功能研究海洋糖类创新药物研发

近期论文

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代表性论文 1. Xuze Ai#, Qingfeng Niu#, Shijie Li, Chanjuan Liu, Nianxi Wu, Guangli Yu*, Guoyun Li*. Eco-friendly ozonation of alginate: Physicochemical characterization and degradation mechanism exploration through mass spectrometry. International Journal of Biological Macromolecules, 2024, 3 (279):135306 2. Qingfeng Niu#, Han Zhou#, Xiaoyao Ma, Yuanyuan Jiang, Chanjuan Liu, Wei Wang*, Guangli Yu*, Guoyun Li*, Anti-enterovirus 71 activity of native fucosylated chondroitin sulfates and their derivatives. CarbohydratePolymers, 2024, 15(346):122657 3. Meimei Xing#, Guoyun Li#, Yang Liu, Luyao Yang, Youjiao Zhang, Yuruo Zhang, Jianhua Ding, Ming Lu*, Guangli Yu*, Gang Hu*. Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a, CarbohydratePolymers, 2023, 303, 120470 4. Xueru Chu#, Yu Zhou#, Shuimi Zhang, Shousheng Liu, Guoyun Li*, Yongning Xin*. Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling, Lipids in Health and Disease, 2022, 21(1):140 5. Chanjuan Liu#, Luyao Yang#, Qingfeng Niu, Guangli Yu*, Guoyun Li*. Carbohydrate microarrays fabricated on poly(2-methylacrylic acid)-based substrates for analysis of carbohydrate–protein interactions. New Journal of Chemistry, 2022, 46, 4300-4306 6.Yinzhi Lang, Yongzhen Zhang, Chen Wang, Limei Huang, Xiaoxiao Liu, Ni Song, Guoyun Li*, Guangli Yu*. Comparison of Different Labeling Techniques for the LC-MS Profiling of Human Milk Oligosaccharides. Frontiers in Chemistry, 2021, 9: 691299 7.Lin Pan, Xuze Ai, Tianyu Fu, Li Ren, Qingsen Shang*, Guoyun Li*, Guangli Yu*. In vitro fermentation of hyaluronan by human gut microbiota:Changes in microbiota community and potential degradation mechanism. , CarbohydratePolymers, 2021, 269, 118313 8. Xin Zhang#, Chen Wang#, Qing Han, Xuan Chen, Guoyun Li*, Guangli Yu*. Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation. Glycoconjugate Journal, 2021, 38, 527–537. 9. Lin Pan#, Weixia Sun#, Qingsen Shang, Qingsen Niu, Chanjuan Liu, Guoyun Li*, Guangli Yu*. In Vitro Fermentation and Isolation of Heparin-degrading Bacteria from Human Gut Microbiota. Anaerobe, 2020, 102289. 10. Ning Zhang, Guoyun Li*, Shijie Li, Chao Cai, Fuming Zhang, Robert J. Linhardt, Guangli Yu. Mass spectrometric evidence for the mechanism of free-radical depolymerization of various types of glycosaminoglycans, Carbohydrate Polymers, 2020, 233: 115847 11. Qingfeng Niu, Guoyun Li*, Chao Li, Qinying Li, Jia Li, Chanjuan Liu, Lin Pan, Shijie Li, Chao Cai, JieJie Hao, Guangli Yu. Two different fucosylated chondroitin sulfates: structural elucidation, stimulating hematopoiesis and immune-enhancing effects. CarbohydratePolymers, 2020, 230: 115698 12.Chao Li, Qingfeng Niu, Shijie Li , Xin Zhang , Chanjuan Liu , Chao Cai , Guoyun Li*, Guangli Yu. Fucoidan from Sea Cucumber Holothuria polii: Structural Elucidation and Stimulation of Hematopoietic Activity.International Journal of Biological Macromolecules, 2020, 154:1123-1131.