车茜 - 中国海洋大学

个人简介

车茜，女，1986年生，博士，副教授。2013年毕业于中国海洋大学药物化学专业获博士学位，2013年至今在中国海洋大学医药学院工作，先后被聘为讲师（2013-2016）、副教授（2017-至今）。一直从事海洋放线菌的分离培养和活性成分研究。在相关领域的国际主流期刊Org. Lett.和J. Nat. Prod.等发表SCI收录论文10余篇，申请发明专利5项，获授权3项，主持承担国家自然科学基金、山东省自然科学基金等4项科研项目。

研究领域

1. 海洋来源放线菌中药物先导化合物的发现：来源于海洋动植物及沉淀物的放线菌的分离及其活性次级代谢产物的研究；2. 拓展药用海洋放线菌新资源的方法学研究：新型培养技术与基因筛选方法研究；次级代谢产物沉默途径的诱导与激活研究。

近期论文

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1. Qian Che#, Hongsheng Tan#, Xiaoning Han, Xiaomin Zhang, Qianqun Gu, Tianjiao Zhu,* and Dehai Li*. Naquihexcin A, a S-Bridged Pyranonaphthoquinone Dimer Bearing an Unsaturated Hexuronic Acid Moiety from a Sponge-Derived Streptomyces sp. HDN-10-293. Org. Lett. 2016, 18 (14), 3358-3361.(IF: 6.732) 2. Qian Che, Tianjiao Zhu, Xin Qi, Attila Mándi, Tibor Kurtán, Xiaomei Mo, Jing Li,Qianqun Gu, and Dehai Li*. Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64. Org. Lett. 2012, 14 (13), 3438-3441. (IF: 6.732) 3. Weiyi Zhang #,Qian Che#, Hongsheng Tan, Xin Qi,Jing Li,Dehai Li,Qianqun Gu, Tianjiao Zhu,* and Ming Liu*. Marine Streptomyces sp. Derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system. Sci Rep-UK, 2017, 7, 42180. (IF: 5.228) 4. Qian Che, Tianjiao Zhu, Robert A. Keyzers, Xiaofang Liu, Jing Li, Qianqun Gu, and Dehai Li*. Polycyclic hybrid isoprenoids from a reed rhizosphere-soil derived Streptomyces sp. CHQ-64. J. Nat. Prod. 2013, 76 (4), 759-763. (IF: 3.662) 5. Qian Che#, Tong Li#, Xiaofang Liu, Tingting Yao, Jing Li, Qianqun Gu, Dehai Li*, Wenli Li*, and Tianjiao Zhu*. Genome Scanning Inspired Isolation of Reedsmycins A-F, Polyene-polyol Macrolides from Streptomyces sp. CHQ-64. RSC Adv. 2015, 29 (5), 22777-22782.(IF: 3.289) 6. Qian Che, Jing Li, Dehai Li, Qianqun Gu and Tianjiao Zhu*. Structure and Absolute Configuration of Drimentine I, an Alkaloid from Streptomyces sp. CHQ-64. J Antibiot. 2016, 69, 467-469. (IF: 2.173) 7. Xiaoning Han, Zengzhi Liu, Zhenzhen Zhang, Xiaomin Zhang, Tianjiao Zhu, Qianqun Gu, Wenli Li, Qian Che,* and Dehai Li*. Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64ΔrdmF. J. Nat. Prod. 2017, 80(5), 1684-1687. (IF: 3.281) 8. Ting Zhang, Meilin Zhu, Guangyu Sun, Na Li, Qianqun Gu, Dehai Li, Qian Che* and Tianjiao Zhu*. Exopisiod B and farylhydrazone C, two new alkaloids from the Antarctic-derived fungus Penicillium sp. HDN14-431. J. Asian Nat. Prod. Res. 2016, 18 (10), 959-965. (IF: 1.009) 9. Feng Li, Wenqiang Guo, Li Wu, Tianjiao Zhu, Qianqun Gu, Dehai Li, Che, Qian*.Arch. Pharm. Res. 2018, 41(1), 30-34. (IF: 2.324)