张国建 - 中国海洋大学

个人简介

张国建，男，博士，副教授，中国海洋大学“青年英才工程”计划资助获得者。2006年6月毕业于中国海洋大学药学专业，获得学士学位；2011年6月毕业于中国海洋大学药物化学专业，获得博士学位。2012年1月至2017年9月先后在纽约州立大学布法罗分校（Blaine Pfeifer 课题组）和俄克拉荷马大学（Robert Cichewicz课题组）从事博士后研究。

研究领域

1. 海洋环境来源微生物功能基因和代谢产物的潜能挖掘、活性次级代谢产物的发现。2. 基于对生物合成途径与生物反应过程的改造和优化生产结构和活性新颖的化合物分子。

近期论文

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1. Tingting Zhao, Yimin Chang, Tianjiao Zhu, Jing Li, Qianqun Gu, Dehai Li, Qian Che* and Guojian Zhang*. α-Pyrone derivatives with cyto-protective activity from two Takla Makan Desert Soil Derived Actinomycete Nocardiopsis Strains Recovered in Seawater Based Medium. Nat. Prod. Res., 2018, online. 2. Lei Fang#, Guojian Zhang#*, Omar El-Halfawy, Eric D. Brown and Blaine. A. Pfeifer*. Broadened Glycosylation Patterning of Heterologously Produced Erythromycin. Biotechnol. Bioeng., 2018, accepted. 3. Feng Li, Zhenzhen Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li. Determination of Taichunamide H and Structural Revision of Taichunamide A. Org. Lett., 2018, 20, 1138–1141. 4. Charles H Jones#,Guojian Zhang#, Roozbeh Nayerhoda, Marie Beitelshees, Andrew Hill, Pooya Rostami, Yi Li, Bruce A Davidson, Paul Knight and Blaine A. Pfeifer. Comprehensive Vaccine Design for Commensal Disease Progression. Sci. Adv., 2017, 3, e1701797. 5. Guojian Zhang, Jing Li, Tianjiao Zhu, Qianqun Gu and Dehai Li. Advanced tools in marine natural drug discovery. Curr. Opin. Biotech. 2016, 43, 13-23. 6. Guojian Zhang, Yi Li, Lei Fang and Blaine A. Pfeifer. Tailoring Pathway Modularity in the Biosynthesis of Erythromycin Analogues Heterologously Engineered in E. coli.Sci. Adv., 2015, 1, e1500077. 7. Tai-Chun Chung, Charles Jones, Akhila Gollakota, Mahmoud Ahmadi, Snehal Rane, Guojian Zhang, Blaine Pfeifer. Improved Escherichia Coli Bactofection and Cytotoxicity by Heterologous Expression of Bacteriophage ΦX174 Lysis Gene E. Mol. Pharm., 2015, 12, 1691-1700. 8. Charles H. Jones, Akhila Gollakota, Mingfu Chen, Tai-Chun Chung, Anitha Ravikrishnan, Guojian Zhang, Blaine A. Pfeifer. Influence of Molecular Weight upon Mannosylated Bio-synthetic Hybrids for Targeted Antigen Presenting Cell Gene Delivery. Biomaterials, 2015, 58, 103-111. 9. Mahmoud Kamal Ahmadi, Samar Fawaz, Charles Jones, Guojian Zhang, and Blaine Pfeifer. Total Biosynthesis and Diverse Applications for the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin. Appl. Environ. Microbiol., 2015, 81, 5290-5298. 10. Kevin Carter, Shuai Shao, Matthew Hoopes, Dandan Luo, Bilal Ahsan, Vladimir Grigoryants, Wentao Song, Haoyuan Huang, Guojian Zhang, Ravindra Pandey, Jumin Geng, Blaine Pfeifer, Charles Scholes, Joaquin Ortega, Mikko Karttunen, Jonathan Lovell. Porphyrin-Phospholipid Liposomes Permeabilized by Near Infrared Light. Nat. Commun., 2014, 5: 3546. 11. Jixing Peng, Huquan Gao, Jing Li, Jing Ai, Meiyu Geng, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Deihai Li. Prenylated Indole Diketopiperazines from the Marine–Derived Fungus Aspergillus versicolor. J. Org. Chem. 2014, 79, 7895-7904. 12. Xinying Yang#,Guojian Zhang#, Xuelian Tang, Jieying Jiao, Sung Yeon Kim, Joo Young Lee, Tianjiao Zhu, Dehai Li, Yong Gab Yun and Qianqun Gu. Toll-like Receptor 4/Nuclear Factor-κB Signaling Pathway is Involved in ACTG-toxin H-mediated Anti-inflammatory Effect. Mol. Cell. Biochem., 2013, 374, 29-36. 13. Xueping Li#, Guojian Zhang#, Tianjiao Zhu, Dehai Li, Qianqun Gu. Strain and culture medium optimization for Production Enhancement of Prodiginines from Marine-derived Streptomyces sp GQQ-10. J. Ocean Univ. China, 2012, 11, 361-365. 14. Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu, and Dehai Li. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32. J. Nat. Prod., 2013, 76, 1946–1957. 15. Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li and Qian-qun Gu. Antiviral Isoindolone Derivatives from an Endophytic Fungus Emericella sp. Associated with Aegiceras corniculatum.Phytochemistry,2011, 72, 1436-1442.