张国建 - 中国海洋大学

个人简介

教育背景 2006-2011 中国海洋大学药物化学博士 2002-2006 中国海洋大学生物技术学士工作经历 2017-至今中国海洋大学医药学院副教授、教授 2014-2016 俄克拉荷马大学博士后 2012-2014 纽约州立大学博士后

研究领域

1. 药用微生物资源发掘和天然药物分子的发现 2. 活性分子的生物合成和微生物代谢工程

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma, Qian Che, Tianjiao Zhu, Dehai Li, Blaine A. Pfeifer*, and Guojian Zhang*. Cyclo-diphenylalanine Production in Aspergillus nidulans through Stepwise Metabolic Engineering. Metab. Eng. 2024, 82, 147-156. Yimin Chang, Luning Zhou, Xuewen Hou, Tianjiao Zhu, Blaine A. Pfeifer, Dehai Li, Xiaoxi He,* Guojian Zhang,* and Qian Che*. Microbial Dimerization and Chlorination of Isoflavones by a Takla Makan Desert-Derived Streptomyces sp. HDN154127. J. Nat. Prod. 2023, 86, 1, 34–44. Guowei Liu, Dan Liu, Zongyuan Li, Jieying Jiao, Xuewen Hou, Xiaomin Zhang, Qian Che, Tianjiao Zhu, Dehai Li, Guojian Zhang*. Overexpression of transcriptional regulator and tailoring enzyme leads to the discovery of anti-inflammatory meroterpenoids from marinederived fungus Alternaria alternata JJY-32. Fron. Mar. Sci., 2022, DOI: 10.3389/fmars.2022.1015684. Xuewen Hou, Changlong Li, Runfang Zhang, Yinping Li, Huadong Li, Yundong Zhang, Han-Shen Tae, Rilei Yu, Qian Che, Tianjiao Zhu, Dehai Li*, Guojian Zhang*. Unusual Tetrahydropyridoindole-Containing Tetrapeptides with Human Nicotinic Acetylcholine Receptors Targeting Activity Discovered from Antarctica-Derived PsychrophilicPseudogymnoascus sp. HDN17-933. Mar. Drugs, 2022, 20, 593. Kaijin Zhang#, Guojian Zhang#, Xuewen Hou, Chuanteng Ma, Junyu Liu, Qian Che, Tianjiao Zhu, Dehai Li*. A Fungal Promiscuous UbiA Prenyltransferase Expands the Structural Diversity of Chrodrimanin-Type Meroterpenoids. Org. Lett., 2022, 24, 2025−2029. Xuewen Hou, Ruonan Sun, Yanyan Feng, Runfang Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang*, Dehai Li*. Peptaibols: diversity, bioactivity, and biosynthesis. Eng. Microbiol., 2022, 2, 100026. Zilu Tang, Yimin Chang, Tianjiao Zhu, Qian Che, Dehai Li*, Guojian Zhang*. Antibacterial angucyclinone and α-pyrone derivatives from desert-derived Nocardiopsis dassonvillei HDN 154151. J. Antibiot., 2022, 75, 380-384. Guoliang Zhou, Tianjiao Zhu, Qian Che, Guojian Zhang*, Dehai Li*. Structural diversity and biological activity of natural p-terphenyls. MLST., 2022, 4, 62-73. Yimin Chang, Qian Che, Li Xing, Chuanteng Ma, Yaxin Han, Tianjiao Zhu, Blaine A. Pfeifer, Jixing Peng, Guojian Zhang* and Dehai Li*. Antibacterial p-Terphenyls with rare 2,2'-bithiazole moiety isolated from marine-derived actinomycete Nocardiopsis sp. HDN154086. J. Nat. Prod. 2021, 84, 4, 1226–1231. Guoliang Zhou, Tianjiao Zhu, Qian Che, Guojian Zhang*, Dehai Li*. Structural diversity and biological activity of natural p-terphenyls. MLST., 2021, DOI:10.1007/s42995-021-00117-8. Chuanteng Ma, Kaijin Zhang, Xianyan Zhang, Guowei Liu, Tianjiao Zhu, Qian Che, Dehai Li and Guojian Zhang*. Heterologous expression and metabolic engineering tools for improving terpenoids production. Curr. Opin. Biotech., 2021, 69, 281-289. Ruonan Sun, Yanyan Feng, Hengyi Xu, Xuewen Hou, Tianjiao Zhu, Qian Che, Blaine Pfeifer, Guojian Zhang* and Dehai Li*. An Efficient Marker Recycling System for Sequential Gene Deletion in a Deep Sea-derived Fungus Acremonium sp. HDN16-126. Synth. Syst. Biotechnol., 2021, 6, 2, 127-133. Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang* and Dehai Li*. Overexpression of Global Regulator brlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium rocae HDN-12-143. Front. Chem., 2020, online. DIO: 89/fchem.2020.00270. Lu Wang, Jieying Jiao, Dan Liu, Xiaomin Zhang, Jing Li, Qian Che, Tianjiao Zhu, Dehai Li* and Guojian Zhang*. Cytotoxic Meroterpenoids from the Sponge‐Associated Fungus Alternaria sp. JJY‐32. Chem. Biodivers., 2020, 17, e2000226. Front. Xueping Ge, Chunxiao Sun, Yanyan Feng, Lingzhi Wang, Jixing Peng, Qian Che, Qianquan Gu, Tianjiao Zhu, Dehai Li and Guojian Zhang*. Anthraquinone Derivatives from a Marine-Derived Fungus Sporendonema casei HDN16-802. Mar. Drugs, 2019, 17:334. Tingting Zhao, Yimin Chang, Tianjiao Zhu, Jing Li, Qianqun Gu, Dehai Li, Qian Che* and Guojian Zhang*. α-Pyrone derivatives with cyto-protective activity from two Takla Makan Desert Soil Derived Actinomycete Nocardiopsis Strains Recovered in Seawater Based Medium. Nat. Prod. Res., 2019, 33(17), 2498-2506. Chunxiao Sun, Shah Mudassir, Zhenzhen Zhang, Yanyan Feng, Yimin Chang, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang* and Dehai Li*. Secondary Metabolites from Deep-Sea Derived Microorganism. Curr. Med. Chem. 2019, DIO: 10.2174/0929867326666190618153950. Guihong Yu, Guangwei Wu, Zichao Sun, Xiaomin Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li and Guojian Zhang*. Cytotoxic tetrahydroxanthone dimers from the mangrove-associated fungus Aspergillus versicolor HDN1009, Mar. Drugs, 2018, 16:335. Lei Fang#, Guojian Zhang#*, Omar El-Halfawy, Eric D. Brown and Blaine. A. Pfeifer*. Broadened Glycosylation Patterning of Heterologously Produced Erythromycin. Biotechnol. Bioeng., 2018, 115, 2771-2777. Zhenzhen Zhang, Xueqian He, Guangwei Wu, Congcong Liu, Changjun Lu, Qianqun Gu, Qian Che, Tianjiao Zhu, Guojian Zhang,* and Dehai Li*. Aniline-tetramic Acids from the Deep-sea Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. J. Nat. Prod. 2018, 81 (7), 1651–1657. Ruiquan Qi, Blaine A Pfeifer* and Guojian Zhang*, Engineering heterologous production of salicylate glucoside and glycosylated variants. Front. Microbiol., 2018, 9, 2441. Zhenzhen Zhang, Xueqian He, Qian Che, Guojian Zhang*, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Sorbicillasins A-B and Scirpyrone K from a Deep-Sea-Derived Fungus, Phialocephala sp. FL30r. Mar. Drugs, 2018, 16 :245. Charles H Jones#, Guojian Zhang#, Roozbeh Nayerhoda, Marie Beitelshees, Andrew Hill, Pooya Rostami, Yi Li, Bruce A Davidson, Paul Knight, Blaine A Pfeifer. Comprehensive vaccine design for commensal disease progression. Sci. Adv., 2017, 3, e1701797. (#Co-first author). Guojian Zhang, Jing Li, Tianjiao Zhu, Qianqun Gu and Dehai Li. Advanced tools in marine natural drug discovery. Curr. Opin. Biotech. 2016, 43, 13-23. Guojian Zhang, Yi Li, Lei Fang and Blaine A. Pfeifer. Tailoring Pathway Modularity in the Biosynthesis of Erythromycin Analogues Heterologously Engineered in E. coli. Sci. Adv., 2015, 1, e1500077. Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu, and Dehai Li. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32. J. Nat. Prod., 2013, 76, 1946–1957. Xinying Yang#, Guojian Zhang#, Xuelian Tang, Jieying Jiao, Sung Yeon Kim, Joo Young Lee, Tianjiao Zhu, Dehai Li, Yong Gab Yun and Qianqun Gu. Toll-like Receptor 4/Nuclear Factor-κB Signaling Pathway is Involved in ACTG-toxin H-mediated Anti-inflammatory Effect. Mol. Cell. Biochem., 2013, 374, 29-36. (#Co-first author). Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li and Qian-qun Gu. Antiviral Isoindolone Derivatives from an Endophytic Fungus Emericella sp. Associated with Aegiceras corniculatum.Phytochemistry, 2011, 72, 1436-1442.