李花月 - 中国海洋大学

个人简介

2011年2月毕业于韩国釜山国立大学（Pusan National University），获药学博士学位；2011年3月至2013年5月在韩国釜山国立大学药学院从事博士后研究工作；2014年7月起，经中国海洋大学“青年英才工程”人才引进在中国海洋大学医药学院工作。近5年在Biochim. Biophys.Acta、J. Nat. Prod.、Mar. Biotechnol.等国际学术期刊上发表论文10余篇。

研究领域

基于基因组信息及代谢组分析策略的海洋微生物次级代谢产物研究。通过基因组采掘（genome mining）技术，激活沉默的生物合成基因簇，从而获得在常规实验室条件下难以被发现的新型次级代谢产物。同时采用二维核磁共振（2D-NMR）代谢组分析策略，迅速鉴定出特定基因簇控制下产生的化合物结构类型及其对生物活性的影响，建立一种“基因簇-化合物-活性”定向筛选体系，获得具有优良活性的新型次级代谢产物，为海洋新药研发提供化合物实体。

近期论文

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1. HuayueLi, Mingzhi Su,MarkT.Hamann,JohnJ.Bowling, HyungSik Kim,JeeH. Jung. Solution structure of a sponge-derived cystine knot peptide and its notable stability. J. Nat. Prod. (2014) 77, 304-310 2. Huayue Li, John J. Bowling, Mingzhi Su, Jongki Hong, Bong-Jin Lee, Mark T. Hamann, Jee H. Jung. Asteropsins B-D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugs. Biochim. Biophys. Acta – Gen. Subjects (2014) 1840, 977-984 3. Huayue Li, John J. Bowling, Frank R. Fronczek, Jongki Hong, Sairam V. Jabba, Thomas F. Murray, Nam-Chul Ha, Mark T. Hamann, Jee H. Jung. Asteropsin A: an unusual cystine-crosslinked peptide from Porifera enhances neuronal Ca2+ influx. Biochim. Biophys. Acta – Gen. Subjects (2013) 1830, 2591-2599 4. Yoon Mi Lee, Min Jeong Kim, Huayue Li, Ping Zhang, BaoquanBao, KaJeong Lee, Jee. H. Jung. Marine-derived Aspergillus species as a source of bioactive secondary metabolites. Mar. Biotechnol. (2013) 14, 499-519 5. Jian Lin Li, Sang Chul Han, EunSookYoo, Sook Shin, Jongki Hong, Zheng Cui, Huayue Li, Jee H. Jung. Anti-inflammatory amino acid derivatives from the ascidian Herdmaniamomus. J. Nat. Prod. (2011) 74, 1792-1797 6. HuayueLi, Hung The Dang, Jianlin Li, Chung JaSim, Jongki Hong, Dong-Kyoo Kim, Jee H. Jung. Pyroglutamyl dipeptides and tetrahydro-β-carboline alkaloids from a marine sponge Asteropussp. Biochem. Syst. Ecol. (2010) 38, 1049-1051 7. Huayue Li, Jianlin Li, Chong-O. Lee, Kyung SookBae, Jongki Hong, Jee H. Jung. Indole oligomers from a marine-sponge associated bacterium Psychrobactersp. Biochem. Syst. Ecol. (2010) 38, 839-841 8. Yoon Mi Lee, Huayue Li, Jongki Hong, Hee Young Cho, Kyung SookBae, MiAe Kim, Dong-Kyoo Kim, Jee H. Jung. Bioactive metabolites from the sponge-derived fungus Aspergillusversicolor.Arch. Pharm. Res.(2010) 33, 231-235 9. Huayue Li, Pramod B. Shinde, HyaJa Lee, EunSookYoo, Chong-O. Lee, Jongki Hong, Sang Ho Choi, Jee H. Jung. Bile acid derivatives from a sponge-associated bacterium Psychrobactersp. Arch. Pharm. Res. (2009) 32, 857-862