李花月 - 中国海洋大学

个人简介

教育背景： 2000.09 - 2004.07，烟台大学，生物技术，学士 2004.09 - 2006.08，韩国新罗大学，生命工学，硕士 2006.09 - 2011.02，韩国釜山大学，海洋天然药物化学，博士工作经历： 2011.03 - 2013.05，韩国釜山大学药学院，博士后 2014.07 - 2023.12，中国海洋大学医药学院，副教授 2024.01 - 至今，中国海洋大学医药学院，教授

研究领域

基于多组学技术的海洋微生物药源分子靶向挖掘及生物合成海洋药源分子的绿色生物制造深度学习与 NMR 代谢组分析技术在新天然产物发现中的应用

近期论文

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代表性论文(#equal contribution; *corresponding author)： 1. Suling Xu,# Nengfei Wang,# Qingzhou Meng, Wenjie Ma, Huayue Li* Metabologenomics-driven discovery of nocardimicins from a psychrophilic Nocardia sp. strain. J. Nat. Prod.2024, DOI:10.1021/acs.jnatprod.4c01140 2. Runyi Wang, Suling Xu, Di Su, Yilei Bao, Luyao Xu, Krister Holmberg, Qinggang Wang, Huayue Li* Sanyensin with an unprecedented architecture: an effective strategy from discovery to stereochemical identification of flexible natural products. Anal. Chem. 2024, 96, 16621-16628. 3. Yi Zhao,# Hu Chen,# Liangguang Yue, Yun Dong, Di Su, Jingyi Lyu, Wenli Li,Huayue Li* Heronamides with unreported skeletons from a deep-sea Streptomyces: discovery and biosynthesis. Org. Chem. Front.2024, 11, 1175-1183. 4. Huiming Huang,# Liangguang Yue,# Fayu Deng, Xiaoyu Wang, Ning Wang, Hu Chen,Huayue Li* NMR-metabolomic profiling and genome mining drive the discovery of cyclic decapeptides from amarine Streptomyces.J. Nat. Prod.2023, 86, 2122-2130 5. Runyi Wang, Yilei Bao, Yujing Dong, Yun Dong, Huayue Li* Genome-directed discovery of antiproliferative bafilomycins from a deepsea-derived Streptomyces samsunensis. Bioorg. Chem.2023, 138, 106599 6.Yun Dong, Enjing Jin, Runyi Wang, Yilei Bao, Huayue Li* New olimycins from a cold-seep derived Streptomyces olivaceus. Chem. Biodivers., 2023, 20, e202300689 7 Yi Zhao, Hu Chen, Lu Yang, Wenli Li,Huayue Li*Amphonal, a new polyene aldehyde from a deep-sea-derived Streptomyces amphotericinicus. Nat. Prod. Res.2023, DOI: 10.1080/14786419.202 8 Jing Liu,# Huayue Li,#* Zengzhi Liu, Tong Li, Fei Xiao,Wenli Li* Youssoufenes A2 and A3, antibiotic dimeric cinnamoyl lipidsfrom the ΔdtlA mutant of a marine-derived Streptomyces strain. Mar. Drugs2022, 20, 394. 9.Yilei Bao,# Huayue Li,#* Yujing Dong, He Duan, Hongcheng Li, and Wenli Li* Genome-guided discovery of antifungal filipins from a deep-sea-derived Streptomyces antibioticus. J. Nat. Prod.2022, 25, 365-374 10.Enjing Jin, Huayue Li,* Zengzhi Liu, Fei Xiao, Wenli Li* Antibiotic Dixiamycins from a Cold-Seep Derived Streptomyces olivaceus.J. Nat. Prod.2021, 84, 2606-2611