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个人简介

教育背景 2002.09~2007.07 中山大学 有机化学 博士 1998.09~2002.06 曲阜师范大学 化学教育 学士 工作经历 2014.01~今 中国海洋大学 医药学院 教授 博士生导师 2011.01~2013.12 中国海洋大学 医药学院 副教授 硕士生导师(2009年~今) 2007.07~2010.12 中国海洋大学 医药学院 讲师 2011.11~2013.12 加州大学圣地亚哥分校Scripps海洋研究所(SIO, UCSD)访问学者 William H Gerwick课题组

研究领域

1. 海洋天然药物化学 2. 海洋药物先导化合物成药性研究 3. 海洋药用生物资源学。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(1) Yang Hai#, Zi-Mu Cai#, Peng-Jie Li, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu*, Chang-Lun Shao*. Trends of antimalarial marine natural products: progresses, challenges and opportunities. Natural Product Reports, 2022, 39: 969–990. (2) Yao-Yao Jiang, Yang Gao, Jian-Yu Liu, Ying Xu, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, and Chang-Lun Shao*. Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo. Journal of Medicinal Chemistry, 2022, 65, 11970–11984. (3) Feng-Wei Guo, Qun Zhang, Yu-Cheng Gu*, Chang-Lun Shao*. Sulfur-containing marine natural products as leads for drug discovery and development. Current Opinion in Chemical Biology, 2023, 75:102330. (4) Yong Qu#, Tian-Yi Zhou#, Feng-Wei Guo#, Mei-Yan Wei, Guang-Ying Chen, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Analogues of natural products yaequinolones as potential inflammatory inhibitors: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2023, 250, 115183. (5) Yang Zhang#, Wei-Feng Xu#, Yunjia Yu#, Qun Zhang, Lianghao Huang, Cui Hao, Chang-Lun Shao*, Wei Wang*. Inhibition of influenza A virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein. Journal of Medical Virology, 2023, 95: e28499. (6) Yi-Qian Han#, Qun Zhang#, Wei-Feng Xu*, Yang Hai, Rong Chao, Cui-Fang Wang, Xue-Mei Hou, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog, asperpyrroindotide A, using LC-MS/MS-based molecular networking. Marine Life Science & Technology, 2023, 5, 85–93. (7) Feng-Wei Guo, Tian-Yi Zhou, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Highly efficient and scalable total syntheses and stereochemical assignment of potent antiinflammatory pesimquinolones I and J. Organic Chemistry Frontiers, 2023, 10, 852. (8) Feng-Wei Guo#, Xiao-Feng Mou#, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones. Communications Chemistry, 2022, 5: 35. (9) Li Xu#, Feng-Wei Guo#, Xue-Qing Zhang#, Tian-Yi Zhou, Chao-Jie Wang, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus. Communications Chemistry, 2022, 5: 80. (10) Yang Hai#, Jia-Jia Geng#, Peng-Jie Li#, Wei-Ping Ma, Cui-Fang Wang, Mei-Yan Wei*, Xue-Mei Hou, Guang-Ying Chen, Yu-Cheng Gu, Ming Liu*, Chang-Lun Shao*. Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. European Journal of Medicinal Chemistry, 2022, 232: 114166. (11) Yao-Yao Jiang#, Shaochun Wu#, Yan-Wei Wu, Yang Gao, Daochen Chong, Changning Sun, Mei-Yan Wei, Yu-Cheng Gu, Chang-Lun Shao*, Yuchao Gu*. New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2022, 240, 114598. (12) Wei-Feng Xu#, Rong Chao#, Yang Hai, Yang-Yang Guo, Mei-Yan Wei, Chang-Yun Wang, and Chang-Lun Shao*. 17-Hydroxybrevianamide N and Its N1-Methyl Derivative, Quinazolinones from a Soft-Coral-Derived Aspergillus sp. Fungus: 13S Enantiomers as the True Natural Products. Journal of Natural Products, 2021, 84: 1353–1358. (13) Rong Chao#, Xue-Mei Hou#, Wei-Feng Xu, Yang Hai, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Targeted Isolation of Asperheptatides from a Coral-Derived Fungus Using LC-MS/MS-Based Molecular Networking and Antitubercular Activities of Modified Cinnamate Derivatives. Journal of Natural Products, 2021, 84: 11–19. (14) Lorena Coronado#, Xue-Qing Zhang#, Doriana Dorta, Nerea Escala, Laura M. Pineda, Michelle G. Ng, Esther del Olmo, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*, and Carmenza Spadafora*. Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives. Journal of Natural Products, 2021, 84: 1434−1441. (15) Chao-Jie Wang#, Xinxin Guo#, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei-Yan Wei, Chang-Lun Shao*, Yuchao Gu*. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl) quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. European Journal of Medicinal Chemistry, 2021, 224:113671. (16) Jin-Man Zhang#, Yao-Yao Jiang#, Qun-Fa Huang#, Xu-Xiu Lu, Guan-Hai Wang*, Chang-Lun Shao*, Ming Liu*, Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo. Pharmacological Research, 2021, 172:105800. (17) Yang Hai, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. The intriguing chemistry and biology of sulfur containing natural products from marine microorganisms (1987–2020). Marine Life Science & Technology, 2021, 3, 488–518. (18) Yun‑Fei Teng#, Li Xu#, Mei‑Yan Wei, Chang‑Yun Wang, Yu‑Cheng Gu, Chang‑Lun Shao*. Recent progresses in marine microbial‑derived antiviral natural products. Archives of Pharmacal Research, 2020, 43:1215–1229 (19) Xue-Mei Hou#, Ting-Mei Liang#, Zhi-Yong Guo, Chang-Yun Wang, Chang-Lun Shao*. Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum. Chemical Communications, 2019, 55, 1104–1107. (20) Xue-Mei Hou, Yue-Ying Li, Yun-Wei Shi, Yao-Wei Fang, Rong Chao, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Integrating Molecular Networking and 1H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi. Journal of Organic Chemistry, 2019, 84, 1228–1237. (21) Xue-Mei Hou, Chang-Yun Wang, William H. Gerwick*, Chang-Lun Shao*. Marine natural products as potential anti-tubercular agents. European Journal of Medicinal Chemistry, 2019, 165, 273–292. (22) Lu Liu#, Yao-Yao Zheng#, Chang-Lun Shao*, Chang-Yun Wang*. Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application. Marine Life Science & Technology, 2019, 1: 60−94. (23) Meng-Qi Zhang, Kai-Xia Xu, Ying Xue, Fei Cao, Lu-Jia Yang, Xue-Mei Hou, Chang-Yun Wang*, Chang-Lun Shao*. Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus Curvularia hawaiiensis TA26-15. Journal of Natural Products, 2019, 82, 2477−2482. (24) Chang-Lun Shao, Xiao-Feng Mou, Fei Cao, Carmenza Spadafora, Evgenia Glukhov, Lena Gerwick, Chang-Yun Wang*, William H. Gerwick*. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. Journal of Natural Products, 2018, 81: 211–215. (25) Xue-Qing Zhang, Xiao-Feng Mou, Ning Mao, Jie-Jie Hao, Ming Liu, Ji-Yong Zheng, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, and antibacterial activities of p-terphenyl derivatives. European Journal of Medicinal Chemistry, 2018, 146: 232–244. (26) Yan-Lai Jia#, Mei-Yan Wei#, Hai-Yan Chen, Fei-Fei Guan, Chang-Yun Wang*, Chang-Lun Shao*. (+)-and (−)-Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro [oxazinane-piperazinedione] Skeleton from Pestalotiopsis sp. Organic Letters. 2015, 17: 4216–4219. (27) Chang-Lun Shao, Roger G. Linington, Marcy J. Balunas, Argelis Centeno, Paul Boudreau, Chen Zhang, Niclas Engene, Carmenza Spadafora, Tina S. Mutka, Dennis E. Kyle, Lena Gerwick, Chang-Yun Wang, William H. Gerwick*. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 2015, 80: 7849–7855. (28) Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Biological and Chemical Diversity of Coral-Derived Microorganisms. Current Medicinal Chemistry, 2015, 22: 3707–3762. (29) Chang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhigang She*, Chang-Yun Wang*. Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus. Journal of Natural Products, 2013, 76: 779−782. (30) Kai-Lin Yang, Mei-Yan Wei, Chang-Lun Shao*, Xiu-Mei Fu, Zhi-Yong Guo, Ru-Fang Xu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin, Chang-Yun Wang*. Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp. Journal of Natural Products, 2012, 75: 935–941. (31) Chang-Lun Shao, Hui-Xian Wu, Chang-Yun Wang*, Qing-Ai Liu, Ying Xu, Mei-Yan Wei, Pei-Yuan Qian, Yu-Cheng Gu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin. Potent antifouling resorcylic acid lactones from the gorgonian-derived fungus Cochliobolus lunatus. Journal of Natural Products, 2011, 74 (4): 629–633. (32) Chang-Lun Shao, Chang-Yun Wang*, Yu-Cheng Gu, Mei-Yan Wei, Jia-Hui Pan, Dong-Sheng Deng, Zhi-Gang She*, Yong-Cheng Lin*. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp., Bioorganic & Medicinal Chemistry Letters, 2010, 20 (11): 3284–3286. (33) Changlun Shao, Changyun Wang, Meiyan Wei, Yucheng Gu, Xuekui Xia, Zhigang She*, Yongcheng Lin*. Structure elucidation of two new xanthone derivatives from the marine fungus Penicillium sp. (ZZF 32#) from the South China Sea. Magnetic Resonance in Chemistry, 2008, 46(11): 1066–1069. (34) Changlun Shao, Zhigang She, Zhiyong Guo, Hong Peng, Xiaoling Cai, Shining Zhou, Yucheng Gu, Yongcheng Lin*. 1H and 13C NMR assignments for two anthraquinones and two xanthones from the mangrove fungus (ZSUH-36). Magnetic Resonance in Chemistry, 2007, 45(5): 434–438.

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