个人简介
教育背景
2002.09~2007.07 中山大学 有机化学 博士
1998.09~2002.06 曲阜师范大学 化学教育 学士
工作经历
2014.01~今 中国海洋大学 医药学院 教授 博士生导师
2011.01~2013.12 中国海洋大学 医药学院 副教授 硕士生导师（2009年~今）
2007.07~2010.12 中国海洋大学 医药学院 讲师
2011.11~2013.12 加州大学圣地亚哥分校Scripps海洋研究所（SIO, UCSD）访问学者 William H Gerwick课题组
近期论文
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Wei-Feng Xu#, Rong Chao#, Yang Hai, Yang-Yang Guo, Mei-Yan Wei, Chang-Yun Wang, and Chang-Lun Shao*. 17-Hydroxybrevianamide N and Its N1-Methyl Derivative, Quinazolinones from a Soft-Coral-Derived Aspergillus sp. Fungus: 13S Enantiomers as the True Natural Products.J. Nat. Prod. 2021, 84(4): 1353–1358.
Rong Chao#,Xue-Mei Hou#,Wei-Feng Xu,Yang Hai,Mei-Yan Wei,Chang-Yun Wang,Yu-Cheng Gu,Chang-LunShao*. Targeted Isolation of Asperheptatides from a Coral-Derived Fungus Using LC-MS/MS-Based Molecular Networking and Antitubercular Activities of Modified Cinnamate Derivatives. J. Nat. Prod.2021, 84(1): 11–19.
Lorena Coronado#, Xue-Qing Zhang#, DorianaDorta, NereaEscala, Laura M. Pineda, Michelle G. Ng, Esther del Olmo, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*, and CarmenzaSpadafora*. Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives. J. Nat. Prod. 2021, 84: 1434−1441
Chao-Jie Wang#, Xinxin Guo#, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei-Yan Wei, Chang-Lun Shao*, Yu-chao Gu*. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl) quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. Eur. J. Med. Chem. 2021, 224:113671.
Jin-Man Zhang#, Yao-Yao Jiang#, Qun-Fa Huang#, Xu-Xiu Lu, Guan-Hai Wang*, Chang-Lun Shao*, Ming Liu*, Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo Pharmacological Research. 2021, 172:105800
Xue-Mei Hou#, Ting-Mei Liang#, Zhi-Yong Guo, Chang-Yun Wang, Chang-Lun Shao*. Discovery, absolute assignments, total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum. Chem. Commun. 2019, 55, 1104–1107.
Xue-Mei Hou, Yue-Ying Li, Yun-Wei Shi, Yao-Wei Fang, Rong Chao, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Integrating molecular networking and 1H NMR to target the isolation of chrysogeamides from a library of marine-derived Penicillium fungi. J. Org. Chem.2019,84, 1228–1237.
Xue-Mei Hou, Chang-Yun Wang, William H. Gerwick*, Chang-Lun Shao*. Marine natural products as potential anti-tubercular agents. Eur. J. Med. Chem.2019, 165, 273–292.
Lu Liu#, Yao-Yao Zheng#, Chang-Lun Shao*,Chang-Yun Wang*. Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application. Mar. Life Sci. & Technol. 2019, 1: 60-94.
Meng-Qi Zhang,Kai-Xia Xu, Ying Xue, Fei Cao, Lu-Jia Yang, Xue-Mei Hou, Chang-Yun Wang*, Chang-Lun Shao*. Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-oneRing from the Zoanthid-Derived FungusCurvulariahawaiiensisTA26-15. J. Nat. Prod. 2019, 82, 2477−2482.
Chang-Lun Shao, Xiao-Feng Mou, Fei Cao, CarmenzaSpadafora, Evgenia Glukhov, Lena Gerwick, Chang-Yun Wang*, William H. Gerwick*. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. J. Nat. Prod. 2018, 81: 211–215.
Xue-Qing Zhang, Xiao-Feng Mou, Ning Mao, Jie-Jie Hao, Ming Liu, Ji-Yong Zheng, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, andantibacterial activities of p-terphenyl derivatives. Eur. J. Med. Chem. 2018, 146: 232–244.
Yan-Lai Jia#,Mei-Yan Wei#, Hai-Yan Chen, Fei-Fei Guan, Chang-Yun Wang*,Chang-Lun Shao*. (+)-and (−)-Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro [oxazinane-piperazinedione] Skeleton from Pestalotiopsis sp. Org. Lett.2015, 17: 4216–4219.
Chang-Lun Shao, Roger G. Linington, Marcy J. Balunas, Argelis Centeno, Paul Boudreau, Chen Zhang, NiclasEngene, CarmenzaSpadafora, Tina S. Mutka, Dennis E. Kyle, Lena Gerwick, Chang-Yun Wang, William H. Gerwick*. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeaniahirsuta. J. Org. Chem.2015, 80:7849–7855.
Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Biological and Chemical Diversity of Coral-Derived Microorganisms. Curr. Med. Chem.2015, 22: 3707–3762.
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