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个人简介

李德海,男,博士,教授,博导,医药学院副院长。国际期刊Curr. Org. Chem、The Natural Products Journal、Lett. Org. Chem.编辑;应用海洋学学报(中文核心期刊)第六届编委会委员。主要从事海洋天然药物化学研究,致力于利用化学和生物学手段从海洋微生物中发现具有潜在药用价值的活性成分。近年来Curr. Opin. Biotech.、J. Med. Chem.、Org. Lett.、J. Org. Chem.、J. Nat. Prod. 等发表SCI收录论文130余篇(第一或通讯作者80余篇),个人H指数36,i10指数97(GoogleScholar数据);已授权专利9项。主持承担国家自然科学基金、山东省、教育部等二十余个项目。 教育背景 2002.09~2007.06 中国海洋大学 药物化学 博士 1998.09~2002.06 山东大学 药学 学士 工作经历 2014.08~2015.08 Universityof California, Los Angeles(Yi Tang group)访问学者 2014.01~至今 中国海洋大学 医药学院 教授 2009.10~2013.12 中国海洋大学 医药学院 副教授 2007.07~2009.07 University of British Columbia, (Raymond Andersen group)博士后

研究领域

1. 深远海、海洋动植物共附生等微生物的分离及功能基因挖掘利用; 2.海洋微生物药物先导化合物的发现、结构优化及构效关系研究; 3.海洋来源真菌次级代谢产物的生物合成

近期论文

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Guangwei Wu#, Guihong Yu#, Yunjia Yu#, Shuang Yang#, Zhongwei Duan, Wei Wang*, Yankai Liu, Rilei Yu, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Chemoreactive-inspired discovery of influenza A virus dual inhibitor to block hemagglutinin-mediated adsorption and membrane fusion. J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c00312 Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang* and Dehai Li*. Overexpression of Global Regulator brlaeA Leads to the Discovery of ew Polyketide in Fungus Penicillium rocae HDN-12-143. 2020,Front. Chem. DIO: 89/fchem.2020.00270. Lu Wang, Jieying Jiao, Dan Liu, Xiaomin Zhang, Jing Li, Qian Che, Tianjiao Zhu, Dehai Li* and Guojian Zhang*. Cytotoxic Meroterpenoids from the Sponge‐Associated Fungus Alternaria sp. JJY‐32. Chem. Biodiv. 2020, DIO: doi.org/10.3389/fchem.2020.00270 Junxiao Wang, Chunxiao Sun, Mudassir Shah, Guoxian Zhang, Qianxun Gu, Tianjiao Zhu, Qian Che*, Dehai Li*. New Metabolites from a Mariana Trench-Derived Actinomycete Nocardiopsis sp. HDN17-237. J. Asian Nat. Prod. Res., doi.org/10.1080/10286020.2019.1681411 Chunxiao Sun, Shah Mudassir, Zhenzhen Zhang, Yanyan Feng, Yimin Chang, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang*, Dehai Li*. Secondary Metabolites from Deep-sea Derived Microorganisms. Curr. Med. Chem. 2020, DOI : 10.2174/0929867326666190618153950 Changjun Lu, Changlong li, Qi Gan, Yi Zhao, Congcong Liu, Qianqun Gu, Tianjiao Zhu, Guojian Zhang, Qian Che and Dehai Li*. Phomanones A-C from Phoma sp. HDN16-618, a Mariana Trench Fungus. Nat. Prod. Commun. 2020,https://doi.org/10.1177/1934578X19858813. Meilin Zhu, Xuewen Zhang, Xuenan Huang, Haotian Wang, Komal Anjum, Qianqun Gu, Tianjiao Zhu, Guojian Zhang, Dehai Li*. Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures and Biological Activities. J. Nat. Prod. 2020, 83, 6, 2045–2053 Qiuying Wang, Kaijin Zhang, Wei Wang, Guojian Zhang, Tianjiao Zhu, Qian Che, Qianqun Gu, Dehai Li*. Amphiepicoccins A−J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus Epicoccum nigrum HDN17-88.J. Nat. Prod.2020, 83, 2, 524–531 Guoliang Zhou, Xiaohui Chen, Xiaomin Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li* .PrenylatedpTerphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ5. J. Nat. Prod. 2020, 83, 1, 8–13 Mudassir Shah#, Chunxiao Sun#, Zichao Sun, Guojian Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu*, Dehai Li*. Antibacterial Polyketides from Antarctica Sponge-derived Fungus Penicillium sp. HDN151272. Mar. Drugs 2020, 18, 71-79; Ling Peng#, Liangwei Li#, Xiaochuan Liu, Jianwei Chen, Chengcheng Shi, Wenjie Guo, Qiwu Xu, Guangyi Fan, Xin Liu*, Dehai Li*. Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabileHXQ-H-1.J. Fungi2020, 6, 7-18; doi:10.3390/jof6010007 Congcong Liu, Zhenzhen Zhang, Yanyan Feng, Qianqun Gu, Dehai Li, Tianjiao Zhu*,. Secondary Metabolites of an Antarctic Derived Fungus Penicillium crustosumHDN153086. Nat Prod Res. 2019, 33(3), 414-419. Guihong Yu, Zichao Sun, Jixing Peng, Meilin Zhu, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and aXylariasp. J. Nat. Prod., 2019, 82, 7, 2013-2017 Jing Yu, Huan Han, Xianyan Zhang, Chuanteng Ma, Chunxiao Sun, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang,Dehai Li*. Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyisYJ-11. Mar. Drugs2019, 17, 446-457. Tingting Zhao, Yimin Chang, Tianjiao Zhu, Jing Li, Qianqun Gu, Dehai Li, Qian Che* and Guojian Zhang*.α-Pyrone derivatives with cyto-protective activity from two TaklaMakan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium.Nat. Prod. Res. 2019, 33 (17), 2498–2506 Xueping Ge, Chunxiao Sun, Yanyan Feng, Lingzhi Wang, Jixing Peng, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li, Guojian Zhang *. Anthraquinone Derivatives from a Marine-derived Fungus SporendonemacaseiHDN16-802. Mar. Drugs2019, 17, 334-344. Chunxiao Sun, Xueping Ge, Shah Mudassir, Guihong Yu, Qian Che, Guojian Zhang, Jixing Peng, Tianjiao Zhu*, Dehai Li*. New Glutamine-Containing Azaphilone Alkaloids from Deep-sea Derived Fungus Chaetomium globosum HDN151398. Mar. Drugs, 2019, 17, 253-263. Liang Qiao, Zhongwei Duan, Yinghan Chen, Yepeng Luan, Qianqun Gu, Yan-Kai Liu*, and Dehai Li*. Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues. J. Org. Chem. 2019, 84, 4451-4457 Guihong Yu, Qiuying Wang, Shan Liu, Xiaomin Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Methylsulfonylated Polyketides Produced by Neosartoryaudagawae HDN13-313 via Exogenous Addition of Small Molecules. J. Nat. Prod., 2019, 82, 998−1001 Guoliang Zhou, Liang Qiao, Xiaomin Zhang, Chunxiao Sun, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Fusaricates H-K and Fusolanones A-B from a Mangrove Endophytic Fungus Fusarium solaniHDN15-410. Phytochemistry 2019, 158, 13-19

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